Volume 14, Issue 3 (May-Jun 2020)                   mljgoums 2020, 14(3): 1-6 | Back to browse issues page

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Kamali M, Kamali A, Taheri sarvtin M. Evaluation of Aflatoxin M1 Level in Human Breast Milk samples from Jiroft, South of Iran. mljgoums. 2020; 14 (3) :1-6
URL: http://mlj.goums.ac.ir/article-1-1166-en.html
1- Department of Internal Medicine, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
2- Department of Infectious Diseases, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran
3- Department of Medical Mycology and Parasitology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran , mehditaheri.mt@gmail.com
Abstract:   (1935 Views)
Background and objective: Human breast milk is the primary food for newborns that possess all essential nutrients for their growth and health. However, breast milk can be contaminated with various toxins including aflatoxin M1 (AFM1), a hydroxylated metabolite of aflatoxin B1 formed in the liver and excreted into the breast milk. This toxin can have immunosuppressive, mutagenic, teratogenic and carcinogenic effects. The present study aimed to investigate the level of AFM1 in human breast milk samples from Jiroft (Kerman Province), Iran.
     Methods: A total of 84 human breast milk samples were collected from lactating mothers who were referred to number one clinic in Jiroft from April 2016 to January 2017. The level of AFM1 was measured using commercial enzyme-linked immunosorbent assay kits.
      Results: Aflatoxin M1 was detected in all (100%) human breast milk samples within the interval values of 3.2 to 8.8 ng/L (mean, 4.1±0.7 ng/L). The level of AFM1 in all samples was lower than the maximum tolerable limit (25 ng/L) suggested by the EU and the Codex Alimentarius Commission.
      Conclusion: Although AFM1 is present in all human breast milk samples from the city of Jiroft, the level of this toxin is within the tolerable limit. Therefore, it seems that infants are not at risk.
Full-Text [PDF 637 kb]   (314 Downloads)    
Research Article: Original Paper | Subject: Mycology
Received: 2018/12/29 | Accepted: 2019/01/14 | Published: 2020/04/30 | ePublished: 2020/04/30

1. Martín-Ortiz A, Barile D, Salcedo J, Moreno FJ, Clemente A, Ruiz-Matute AI, et al. Changes in Caprine Milk Oligosaccharides at Different Lactation Stages Analyzed by High Performance Liquid Chromatography Coupled to Mass Spectrometry. J Agric Food Chem. 2017; 65(17): 3523-3531. doi: 10.1021/acs.jafc.6b05104. [DOI] [PubMed] [Google Scholar]
2. Skouteris H, Bailey C, Nagle C, Hauck Y, Bruce L, Morris H. Interventions Designed to Promote Exclusive Breastfeeding in High-Income Countries: A Systematic Review Update. Breastfeed Med. 2017; 12(10): 604-614. doi: 10.1089/bfm.2017.0065. [DOI] [PubMed] [Google Scholar]
3. Chetwynd EM, Stuebe AM, Rosenberg L, Troester M, Rowley D, Palmer JR. Cumulative lactation and onset of hypertension in African American women. Am J Epidemiol. 2017; 186(8): 927-934. doi: 10.1093/aje/kwx163. [DOI] [PubMed] [Google Scholar]
4. Owino VO, Bahwere P, Bisimwa G, Mwangi CM, Collins S. Breastmilk intake of 9-10-mo-old rural infants given a ready-to-use complementary food in South Kivu, Democratic Republic of Congo. Am J Clin Nutr. 2011; 93: 1300-4. doi: 10.3945/ajcn.110.006544. [DOI] [PubMed] [Google Scholar]
5. Kamali M, Taheri Sarvtin M. SDS-PAGE protein profile of Candida albicans isolated from patients with atopic dermatitis. South Asian J Exp Biol. 2016; 6(3): 92-94. [Google Scholar]
6. Polanco Rodríguez ÁG, Inmaculada Riba López M, Angel DelValls Casillas T, León JA, Anjan Kumar Prusty B, Álvarez Cervera FJ. Levels of persistent organic pollutants in breast milk of Maya women in Yucatan, Mexico. Environ Monit Assess. 2017; 189(2): 59. doi: 10.1007/s10661-017-5768-y. [DOI] [PubMed] [Google Scholar]
7. Saleh-Lakha S, Leon-Velarde CG, Chen S, Lee S, Shannon K, Fabri M, et al. A Study To Assess the Numbers and Prevalence of Bacillus cereus and Its Toxins in Pasteurized Fluid Milk. J Food Prot. 2017; 80(7): 1085-1089. [DOI] [PubMed] [Google Scholar]
8. Mehmeti I, Bytyqi H, Muji S, Nes IF, Diep DB. The prevalence of Listeria monocytogenes and Staphylococcus aureus and their virulence genes in bulk tank milk in Kosovo. J Infect Dev Ctries. 2017; 11(3): 247-254. doi: 10.3855/jidc.8256. [DOI] [PubMed] [Google Scholar]
9. Compare D, Nardone G. The role of gut microbiota in the pathogenesis and management of allergic diseases. Eur Rev Med Pharmacol Sci. 2013; 17(2): 11-7. [PubMed] [Google Scholar]
10. Kamali M, Mehni S, Kamali M, Taheri Sarvtin M. Detection of ochratoxin A in human breast milk in Jiroft city, south of Iran. Current Medical Mycology. 2017; 3(3): 1- 4. doi: 10.29252/cmm.3.3.1 [DOI] [PubMed] [Google Scholar]
11. Taheri Sarvtin M, Hedayati MT, Abastabar M, Shokohi T. Debaryomyces hansenii colonization and its protein profile in psoriasis. Iran J Dermatol. 2014; 17(70):134-7. [Google Scholar]
12. Katsurayama AM, Martins LM, Iamanaka BT, Fungaro MHP, Silva JJ, Frisvad JC, et al. Occurrence of Aspergillus section Flavi and aflatoxins in Brazilian rice: From field to market. Int J Food Microbiol. 2017; 266: 213-221. doi: 10.1016/j.ijfoodmicro. [DOI] [PubMed] [Google Scholar]
13. Essawet N, Abushahma H, Inbaia S, Najii A, Amra HA. Natural Incidence of Aflatoxins and Ochratoxin A Nuts Collected from Local Market in Tripoli. Int J Curr Microbiol App Sci. 2017; 6(3): 1479-1486. DOI: 10.20546/ijcmas.2017.603.170. [DOI] [Google Scholar]
14. Khazaeli P, Mehrabani M, Heidari MR, Asadikaram G, Lari Najafi M. Prevalence of Aflatoxin Contamination in Herbs and Spices in Different Regions of Iran. Iran J Public Health. 2017; 46(11): 1540-1545. [PubMed] [Google Scholar]
15. Torović L, Trajković Pavlović L, Popović M. Ochratoxin A and aflatoxin B1 in breakfast cereals marketed in Serbia - occurrence and health risk characterisation. Food Addit Contam Part B Surveill. 2017; 10(3): 176-184. doi: 10.1080/19393210.2017.1285358. [DOI] [PubMed] [Google Scholar]
16. Kunter İ, Hürer N, Gülcan HO, Öztürk B, Doğan İ, Şahin G. Assessment of Aflatoxin M1 and Heavy Metal Levels in Mothers Breast Milk in Famagusta, Cyprus. Biol Trace Elem Res. 2017; 175(1): 42-49. doi: 10.1007/s12011-016-0750-z. [DOI] [PubMed] [Google Scholar]
17. Guo W, Wu L, Fan K, Nie D, He W, Yang J, et al. Reduced Graphene Oxide-Gold Nanoparticle Nanoframework as a Highly Selective Separation Material for Aflatoxins. Sci Rep. 2017; 7(1): 14484. doi: 10.1038/s41598-017-15210-1. [DOI] [PubMed] [Google Scholar]
18. Lu H, Liu F, Zhu Q, Zhang, Li T, Chen J. Aflatoxin B1 can be complexed with oxidised tea polyphenols and the absorption of the complexed aflatoxin B1 is inhibited in rats. J Sci Food Agric. 2017; 97(6): 1910-1915. [DOI] [PubMed] [Google Scholar]
19. Fasullo M, Freedland J, St John N, Cera C, Egner P, Hartog M, et al. An in vitro system for measuring genotoxicity mediated by human CYP3A4 in Saccharomyces cerevisiae. Environ Mol Mutagen. 2017; 58(4): 217-227. [DOI] [PubMed] [Google Scholar]
20. Ramirez AG, Muñoz E, Parma DL, Michalek JE, Holden AEC, Phillips TD, et al. Lifestyle and Clinical Correlates of Hepatocellular Carcinoma in South Texas: A Matched Case-control Study. Clin Gastroenterol Hepatol. 2017; 15(8): 1311-1312. [DOI] [PubMed] [Google Scholar]
21. El-Nekeety AA, Salman AS, Hathout AS, Sabry BA, Abdel-Aziem SH, Hassan NS. Evaluation of the bioactive extract of actinomyces isolated from the Egyptian environment against aflatoxin B1-induce cytotoxicity, genotoxicity and oxidative stress in the liver of rats. Food Chem Toxicol. 2017; 105: 241-255. doi: 10.1016/j.fct.2017.04.024. [DOI] [PubMed] [Google Scholar]
22. Gürbay A, Sabuncuoğlu SA, Girgin G, Şahin G, Yiğit S, Yurdakök M, et al. Exposure of newborns to aflatoxin M1 and B1 from mothers' breast milk in Ankara, Turkey. Food Chem Toxicol. 2010; 48(1): 314-9. doi: 10.1016/j.fct.2009.10.016. [DOI] [PubMed] [Google Scholar]
23. Sadeghi N, Oveisi MR, Jannat B, Hajimahmoodi M, Bonyani H, Jannat F. Incidence of aflatoxin M1 in human breast milk in Tehran, Iran. Food Control. 2009; 20(1): 75-78. DOI: 10.1016/j.foodcont.2008.02.005. [DOI] [Google Scholar]
24. Ghiasian SA, Maghsood AH. Infants' Exposure to Aflatoxin M1 from Mother's Breast Milk in Iran. Iran J Public Health. 2012; 41(3): 119-126. [PubMed] [Google Scholar]
25. Keskin Y, Baskaya R, Karsli S, Yurdun T, O¨zyaral O. Detection of Aflatoxin M1 in Human Breast Milk and Raw Cow's Milk in Istanbul, Turkey. J Food Prot. 2009; 72(4): 885-889. [DOI] [PubMed] [Google Scholar]
26. Jafarian-Dehkordi A, Pourradi N. Aflatoxin M1 contamination of human breast milk in Isfahan, Iran. Adv Biomed Res. 2013; 2: 86. doi: 10.4103/2277-9175.122503. [DOI] [PubMed] [Google Scholar]
27. Tomerak RH, Shaban HH, Khalafallah OA, El Shazly MN. Assessment of exposure of Egyptian infants to aflatoxin M1 through breast milk. J Egypt Public Health Assoc. 2011;86(3-4):51-5. doi: 10.1097/01.EPX.0000399138.90797.40. [DOI] [PubMed] [Google Scholar]
28. Mahdavi R, Nikniaz L, SR Arefhosseini, Vahed Jabbari M. Determination of Aflatoxin M1 in Breast Milk Samples in Tabriz-Iran. Matern Child Health J. 2010 Jan;14(1):141-5. doi: 10.1007/s10995-008-0439-9. [DOI] [PubMed] [Google Scholar]
29. Herrera Insua I, Gomez HF, Diaz Gonzalez VA, Chaturvedi P, Newburg DS, Cleary TG. Human milk lipids bind Shiga toxin. Adv Exp Med Biol. 2001; 501: 333-339. DOI: 10.1007/978-1-4615-1371-1_41. [DOI] [PubMed] [Google Scholar]
30. Amir LH, Donath S. A systematic review of maternal obesity and breastfeeding intention, initiation and duration. BMC Pregnancy Childbirth. 2007; 7(9): 1-14. DOI: 10.1186/1471-2393-7-9. [DOI] [PubMed] [Google Scholar]

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