Volume 12, Issue 2 (Mar-Apr 2018)                   mljgoums 2018, 12(2): 32-37 | Back to browse issues page


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Moazzami M, Askari A. Effect of Six Months of Aerobic Exercise on Lipid Profile, Inflammatory Markers and Risk Factors of Cardiovascular Disease in Obese Women. mljgoums 2018; 12 (2) :32-37
URL: http://mlj.goums.ac.ir/article-1-1062-en.html
1- Department of Exercise Physiology, Faculty of Physical Education & Sport Science, Ferdowsi University of Mashhad, Mashhad, Iran , Mahtab.moazami@gmail.com
2- Department of physical education & Sport Science, Gorgan Branch, Islamic Azad University, Gorgan, Iran
Abstract:   (22837 Views)
ABSTRACT
          Background and objectives: The aim of this study was to investigate the effects of six months of aerobic exercise on lipid profile, inflammatory markers, and risk factors of cardiovascular disease in middle-aged obese women.
          Methods: Fifteen obese woman (age range: 35 to 45 years) with BMI of ≥30 Kg/m2 were enrolled via purposeful and convenience sampling. The participants were randomly divided into training (n=10) and control (n=5) groups.  Blood samples (7 ml) were taken from all participants before the first training session and after the last training session. The women performed 60 minutes of aerobic exercise at 55-65% of heart rate reserve, three sessions a week, for six months. Data was analyzed using independent and paired t-tests and Mann-Whitney U and Wilcoxon tests at significance of 0.05.
          Results: After the six-month aerobic exercise, C-reactive protein, low-density lipoprotein, triglycerides, total cholesterol and high-density lipoprotein/total cholesterol decreased significantly. The exercise intervention also caused a significant increase in the concentrations of high-density lipoprotein and apolipoprotein A.
          Conclusion: Aerobic exercise can reduce the level of inflammatory markers associated with risk of cardiovascular disease and atherosclerosis.
          Keywords: Lipid profile, Inflammatory markers, Obese women, Apolipoprotein, Aerobic exercise.
Full-Text [PDF 552 kb]   (2085 Downloads)    
Research Article: Original Paper |
Received: 2018/03/14 | Accepted: 2018/03/14 | Published: 2018/03/14 | ePublished: 2018/03/14

References
1. Despres JP. Health consequences of visceral obesity. Annals of Medicine. 2001; 33(8): 534-41. [DOI:10.3109/07853890108995963]
2. Nadimi M. Heaithy heart: What must Know general: A Guide to cognition and preventing heart diseases.3th ed. Sales Pub. 2009; 145-168. [Persian]
3. Spiegelman BM, Flier JS. Obesity and the regulation of energy balance .Cell. 2001; 104(4): 531-43. [DOI:10.1016/S0092-8674(01)00240-9]
4. Despres JP, Pascot A, lemieux I. Risk factors associated with obesity: a metabolic perspective. Ann Endocrinol . 2000; 61 suppl 6: 31-38.
5. Despres JP, lemieux I, Dagenais GR, Cantin B, Lamarche B. Evaluation and management of atherogenic dyslipidemia: beyond low-density lipoprotein cholesterol. CMAJ. 2002; 165(10): 1331-1333.
6. Braith RW, Stewart KJ. Resistance exercise training: Its role in the prevention of cardiovascular disease. Circulation. 2006; 113(22): 2642-50. [DOI:10.1161/CIRCULATIONAHA.105.584060]
7. Dehghan A, Kardys I, de Maat MP, Uitterlinden AG, Sijbrands EJ, Bootsma AH, et al. Genetic Variation, C-reactive Protein Levels, and Incidence of Diabetes. Diabetes. 2007; 56(3): 872-9. [Persian] [DOI:10.2337/db06-0922]
8. Koozehchian MS, Nazem F, Kreider RB, Roberts WJ, Best TM, Rong Y, Zuo L. The role of exercise training on lipoprotein profiles in adolescent males. Lipids Health Dis. 2014; 13(1): 95. doi: 10.1186/1476-511X-13-95. [DOI:10.1186/1476-511X-13-95]
9. Hansson, GK. "Inflammation, atherosclerosis, and coronary artery disease". N Engl J Med. 2005; 352(16): 1685-1695. [DOI:10.1056/NEJMra043430]
10. Olson TP, Dengel DR, Leon AS, Schmitz KH. Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women. Int J Obes (Lond). 2007; 31: 996-1003. [DOI:10.1038/sj.ijo.0803534]
11. Wang JS, Chow SE. Effects of exercise training and detraining on oxidized low-density lipoprotein- otentiated platelet function in men. Arch Phys Med Rehabil 2004; 85(9):1531-7. [DOI:10.1016/j.apmr.2003.08.112]
12. Volaklis KA, Spassis AT, Tokmakidis SP. Land versus water exercise in patients with coronary artery disease: effects on body composition, blood lipids, and physical fitness. Am Heart J 2007; 154(3): 560-566. [DOI:10.1016/j.ahj.2007.06.029]
13. Nicklas BJ, Hsu FC, Brinkley TJ, Church T, Goodpaster BH, Kritchevsky SB, et al. Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc. 2008; 56(11): 2045-52. doi: 10.1111/j.1532-5415.2008.01994.x. [DOI:10.1111/j.1532-5415.2008.01994.x]
14. Ding D, Li X, Qiu J, Li R, Zhang Y, Su D, et al. Serum Lipids, Apolipoproteins, and Mortality among Coronary Artery Disease Patients. Biomed Res Int Epub. 2014; 2014: 709756. doi: 10.1155 /2014/709756.
15. Khajei R, Soltani M, Hejazi S m, Nematolahi S N, Zendedel A, Ashkani far. The effect of aquatic aerobics exercises on some of cardiovascular risk factors in patients with multiple scleroesis. http://osub.mums.ac.ir/osub/nilfr/njmsnm/index.php. Article 6, Volume 2, Issue 1, Spring 2012, Page 65-74. .{persian}
16. Holme I, Hostmark AT, Anderssen SA. ApoB but not LDL-cholesterol is reduced by exercise training in overweight healthy men. Results from the 1-year randomized Oslo diet and exercise study. J Intern Med 2007; 262(2): 235-243. DOI:10.1111/j.1365-2796.2007.01806.x. [DOI:10.1111/j.1365-2796.2007.01806.x]
17. Paoli A, Pacelli QF, Moro T, Marcolin G, Neri M, Battaglia G, Sergi G, Bolzetta F, Bianco A. Effects of high-intensity circuit training, low-intensity circuit training and endurance training on blood pressure and lipoproteins in middle-aged overweight men. Lipids Health Dis. 2013; 12:131. [DOI:10.1186/1476-511X-12-131]
18. Ramalho AC, de Lourdes Lima M, Nunes F, Cambuí Z, Barbosa C, Andrade A, et al. The effect of resistance versus aerobic training on metabolic control in patients with type-1 diabetes mellitus. Diabetes Res Clin Pract 2006; 72(3): 271-276. DOI:10.1016/j.diabres.2005.11.011. [DOI:10.1016/j.diabres.2005.11.011]
19. Esfaranjani F, Rashidi F, Mardani SM. The EffectT of Aerobic Exercise on blood glucose, lipid profile and APO B-100 in patients with type II diabetes. Journal 0f ardabil university of medical sciences (JAUMS) summer 2013; 13(2):132-141. [Persian]
20. Haghighi AH, Yaghoubi M, Hosseini kakhk SAR. The Effect of Eight Weeks Aerobic Training and Green Tea Supplementation on Body Fat Percentage and Serum Lipid Profiles in Obese and Overweight Women. Medical Journal of Mashhad University of Medical Sciences. 2013; 56(4): 211-218. [Persian]
21. Law MR, Wald NJ, Rudnicka AR. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ 2003; 326(7404): 1423. DOI:10.1136/bmj.326.7404.1423. [DOI:10.1136/bmj.326.7404.1423]
22. Zois CE, Tokmakidis SP, Volaklis KA, Kotsa K, Touvra AM, Douda E, et al. Lipoprotein profile, glycemic control and physical fitness after strength and aerobic training in post-menopausal women with type 2 diabetes. Eur J Appl Physiol. 2009; 106(6): 901-doi: 10.1007/s00421-009-1078-6. [DOI:10.1007/s00421-009-1078-6]
23. Mashaykhi N, Sadrneya S, Acherei A, Javaheri J, ahmadlou M. The correlation between serum Apo lipoprotein A1 and Apo lipoprotein B with coronary artery disease and its severity. Arak University of Medical Sciences Journal. 2013; 16(6): 75-83. [Persian] Daneshpour M, Faam B, Hedayati M, Azizi F. Presence of the X+ Allele in Apolipoprotein B Gene Increase the Total Cholesterol and Apolipoprotein B Concentration in Tehranian People. Iranian Journal of Endocrinology and Metabolism. 2011; 12(6): 588-593.[Persian]
24. Makaridze Z, Giorgadze E, Asatiani K. Association of the apolipoprotein b/apolipoprotein a-I ratio, metabolic syndrome components, total cholesterol, and low-density lipoprotein cholesterol with insulin resistance in the population of georgia. Int J Endocrinol. 2014;2014:925650. doi: 10.1155/2014/925650. [DOI:10.1155/2014/925650]
25. Lee J, Cho JY, Kim WK. Anti-inflammation effect of Exercise and Korean red ginseng in aging model rats with diet-induced atherosclerosis. Nutr Res Pract. 2014; 8(3): 284-91. doi: 10.4162/nrp.2014.8.3.284. [DOI:10.4162/nrp.2014.8.3.284]
26. Ramezanpour MR, Hejazi SM, Hosseinnezhad M. The Comparison of HS-CRP, TG, LDL-c and HDL-c in Active and Non Active Middle-aged Women. Medical Journal of Mashhad University of Medical Sciences. 2013; 56(2): 93-98. [Persian]
27. Zolfaghary M, Taghian F, Hedayati M. Comparing the effect of green tea extract consumption, aerobic exercise and combination of these two methods on CRP Level in obese women. Razi Journal of Medical Sciences. 2013; 20(110): 8-21. [Persian]
28. Shih KC, Janckilab AJ, Kwok CF, Ho LT, Chou YC, Chao TY. Effects of exercise on insulin sensitivity, inflammatory cytokines, and serum tartrate-resistant acid phosphatase 5a in obese Chinese male adolescents. Metabolism Clinical and Experimental Metabolism. 2010; 59(1):144-51. doi: 10.1016/j.metabol.2009.06.035. [DOI:10.1016/j.metabol.2009.06.035]
29. Taghian F. Homocystein and C-reactive protein response to acute training in obese and non-obese females. Quarterly of Ofoghe Danesh. 2012;18(3): 129-134. [Persian] Leon AS, Sanches OA. Response of blood lipids to exercise training alone or combined with dietary intervention. Med Sci Sports Exerc. 2001; 33(6 suppl):S502-S515.
30. Lee YH, Song YW, Kim HS, Lee SY, Jeong HS, Suh SH, et al. The effects of an exercise program on anthropometric, metabolic, and cardiovascular parameters in obese children, Korean Circ J. 2010; 40(4):179-84. doi: 10.4070/kcj.2010.40.4.179. [DOI:10.4070/kcj.2010.40.4.179]
31. Okita K, Nishijima H, Murakami T, Nagai T, Morita N, Yonezawa K, et al. Can exercise training with weight loss lower serum C-reactive protein levels? Arterioscler Thromb Vasc Biol. 2004; 24(10): 1868-73. [DOI:10.1161/01.ATV.0000140199.14930.32]
32. Kelly AS, Steinberger J, Olson TP, Dengel DR. In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. Metabolism. 2007; 56(7): 1005-9. [DOI:10.1016/j.metabol.2007.03.009]
33. Khazraee Ganji Far Z, Mabani M, Sokhanvar Dastjerdi sh. A comparison of HS-CRP, triglycerides and cholesterol inflammatory markers in active men after eccentric. International Journal of Sport Studies. 2016; Vol., 6 (5), 277-281.
34. Reed JL, De Souza MJ, Williams NI. Effects of Exercise Combined with Caloric Restriction on Inflammatory Cytokines. Appl Physiol Nutr Metab. 2010; 35(5):573-82. doi: 10.1139/H10-046. [DOI:10.1139/H10-046]
35. Danzig V, Míková B, Kuchynka P, Benáková H, Zima T, Kittnar O, et al. Levels of Circulating Biomarkers at Rest and after Exercise in Coronary Artery Disease Patients. Physiol Res 2010; 59(3): 385-92.

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.