Volume 10, Issue 4 (12-2022)                   Jorjani Biomed J 2022, 10(4): 60-69 | Back to browse issues page

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Hashemi Shiri Z, Bagherpour T, nemati N. Aerobic Training and Curcumin can Improve Adiponectin Gene Expression in Adipose Tissue and Body Mass Index of Rats Fed with High-Fat Diet. Jorjani Biomed J 2022; 10 (4) :60-69
URL: http://goums.ac.ir/jorjanijournal/article-1-928-en.html
1- Department of Sports Physiology, Damghan Branch, Islamic Azad University Damghan, Damghan, I.R. Iran.
2- Department of Sports Physiology, Damghan Branch, Islamic Azad University Damghan, Damghan, I.R. Iran. , bagherpour@damghaniau.ac.ir
3- Department of Sports Physiology, Damghan Branch, Islamic Azad University Damghan, Damghan, I.R
Abstract:   (67 Views)
Background: Obesity has been recognized as a global problem that is increasing day by day. Although t Background: Obesity has been recognized as a global problem that is increasing day by day. Although the favorable effects of training and herbal supplements have been reported in this regard, the synergistic effects of the two are still a challenge for researchers. The purpose of this study was to investigate the effect of six weeks of Aerobic Training (AT) and Curcumin (Cu) consumption on adiponectin gene expression in the visceral adipose tissue and some anthropometric indicators of rats fed with High-Fat Diet (HFD).
Material and Methods: In this experimental study, 40 rats with HFD (1.5 mg/kg/day high-fat emulsion) were randomly divided into five groups, including: (1) Healthy Control (HC), (2) High-Fat Diet Control (HFD), (3) HFD+Cu, (4) HFD+AT, and (5) HFD+Cu+AT. Aerobic training was carried out for six weeks, five sessions per week and each session of training was performed 10-50 minutes at a speed of 25-30 meters per minute and a slope of 15 degrees. Also, curcumin was fed to rats by gavage in the amount of 1.5 mg/kg/day. One-way analysis of variance with Tukey's post hoc test was used to analyze adiponectin and ANCOVA test with Bonferroni's test was used to analyze BMI. Data were analyzed in Prism GraphPad PRISM 3.8.3 software (P≤0.05).
Results: Adiponectin gene expression levels in the HFD+AT, HFD+Cu and HFD+AT+Cu groups were significantly higher than the HFD group (P≥0.05). Weight and BMI levels in the HFD+AT and HFD+AT+Cu groups were significantly lower than the HFD (P≥0.05). Also, in the HFD+AT+Cu group, the weight and BMI levels were significantly lower and the adiponectin levels were significantly higher than the HFD+Cu group (P≥0.05).
Conclusion: It seems that exercise training and curcumin consumption both individually and synergistically can be effective in improving anthropometric characteristics by affecting adiponectin levels.he favorable effects of training and herbal supplements have been reported in this regard, the synergistic effects of the two are still a challenge for researchers.
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Type of Article: Original article | Subject: Health
Received: 2022/09/3 | Accepted: 2022/11/22 | Published: 2022/12/31

References
1. Guerreiro VA, Carvalho D, Freitas P. Obesity, Adipose Tissue, and Inflammation Answered in Questions. J Obes. 2022; 252516. 1-11. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
2. Davari F, Alimanesh Z, Alimanesh Z, Salehi O, Hosseini SA. Effect of training and crocin supplementation on mitochondrial biogenesis and redox-sensitive transcription factors in liver tissue of type 2 diabetic rats. Arch Physiol Biochem. 2020;1-6. [DOI] [PMID] [Google Scholar]
3. Hosseini SA, Norouzi S, Rafiee N, Farzanegi P, Salehi O, Farkhaie F. Interactive Effects of Endurance Training and Crocin on Aerobic Capacity, Dietary Intake and Weight of High-Fat Diet-Induced Type 2 Diabetic Rats. J Nutr Sci Diet. 2018;4(3): 65-74. [view at publisher] [Google Scholar]
4. Senkus KE, Crowe-White KM, Bolland AC, Locher JL, Ard JD. Changes in adiponectin: leptin ratio among older adults with obesity following a 12-month exercise and diet intervention. Nutr Diabetes. 2022;12(1):1-7. [DOI] [PMID] [PMCID] [Google Scholar]
5. Ko K, Woo J, Bae JY, Roh HT, Lee YH, Shin KO. Exercise training improves intramuscular triglyceride lipolysis sensitivity in high-fat diet induced obese mice. Lipids Health Dis. 2018;17(1):1-7. [DOI] [PMID] [PMCID] [Google Scholar]
6. Babaei P, Hosseini R. Exercise training modulates adipokines dysregulations in metabolic syndrome. Sport Med Heal Sci. 2022; 20;4(1):18-28. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
7. Ouerghi N, Fradj MK Ben, Duclos M, Bouassida A, Feki M, Weiss K, et al. Effects of High-Intensity Interval Training on Selected Adipokines and Cardiometabolic Risk Markers in Normal-Weight and Overweight/Obese Young Males. A Pre-Post Test Trial. Biology (Basel). 2022;11(6):853. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
8. Hosseini SA, Hamzavi K, Safarzadeh H, Salehi O. Interactive effect of swimming training and fenugreek (Trigonella foenum graecum L.) extract on glycemic indices and lipid profile in diabetic rats. Arch Physiol Biochem. 2020;1-5. [DOI] [Google Scholar]
9. Nezafat Absardi M, Shadmehri S, Salehi OR, Hajisadeghi H. The Interactional Effects of Endurance Training and Aloe Vera Gel on Alanine Aminotransferase and Aspartate Aminotransferase levels in Diabetic Rats. Yafte. 2018; 20 (1) :99-111. [view at publisher] [Google Scholar]
10. Kasprzak-Drozd K, Oniszczuk T, Gancarz M, Kondracka A, Rusinek R, Oniszczuk A. Curcumin and Weight Loss: Does It Work? Int J Mol Sci. 2022;23(2):639. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
11. Varì R, Scazzocchio B, Silenzi A, Giovannini C, Masella R. Obesity-associated inflammation: does curcumin exert a beneficial role? Nutrients. 2021;13(3):1021. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
12. Akbari M, Lankarani KB, Tabrizi R, Ghayour-Mobarhan M, Peymani P, Ferns G, et al. The effects of curcumin on weight loss among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Front Pharmacol. 2019;10:649. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
13. Bradford PG. Curcumin and obesity. Biofactors. 2013;39(1):78-87. [DOI] [PMID] [Google Scholar]
14. Vajragupta O, Boonchoong P, Watanabe H, Tohda M, Kummasud N, Sumanont Y. Manganese complexes of curcumin and its derivatives: evaluation for the radical scavenging ability and neuroprotective activity. Free Radic Biol Med. 2003;35(12):1632-1644. [view at publisher] [DOI] [PMID] [Google Scholar]
15. Noura M, Arshadi S, Zafari A, Banaeifar A. The effect of running on positive and negative slopes on TNF-α and INF-γ gene expression in the muscle tissue of rats with Alzheimer's disease. J Basic Res Med Sci. 2020;7(1):35-42. [DOI] [Google Scholar]
16. Meshkibaf MH, Maleknia M, Noroozi S. Effect of curcumin on gene expression and protein level of methionine sulfoxide reductase A (MSRA), SOD, CAT and GPx in Freund's adjuvant inflammation-induced male rats. J Inflamm Res. 2019;12:241. [DOI] [PMID] [PMCID] [Google Scholar]
17. Li X, Zhang D, Vatner DF, Goedeke L, Hirabara SM, Zhang Y, et al. Mechanisms by which adiponectin reverses high fat diet-induced insulin resistance in mice. Proc Natl Acad Sci. 2020;117(51):32584-32593. [DOI] [PMID] [PMCID] [Google Scholar]
18. Einollahi N, Alirezaee A. A review of adipose tissue hormones and their functions in the body. Lab Diagnosis. 2016;8(33):23-34. [view at publisher] [Google Scholar]
19. Shahidi F, Pirhadi S. The effect of physical exercise and training on serum leptin levels. Razi J Med Sci. 2014;21(126):1-14. [Google Scholar]
20. Becic T, Studenik C, Hoffmann G. Exercise increases adiponectin and reduces leptin levels in prediabetic and diabetic individuals: systematic review and meta-analysis of randomized controlled trials. Med Sci. 2018;6(4):97. [DOI] [PMID] [PMCID] [Google Scholar]
21. Wang X, You T, Murphy K, Lyles MF, Nicklas BJ. Addition of exercise increases plasma adiponectin and release from adipose tissue. Med Sci Sports Exerc. 2015;47(11):2450. [DOI] [PMID] [PMCID] [Google Scholar]
22. Jeon J-Y, Han J, Kim H-J, Park MS, Seo DY, Kwak Y-S. The combined effects of physical exercise training and detraining on adiponectin in overweight and obese children. Integr Med Res. 2013;2(4):145-50. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
23. Banaii Broojeni J, Keshavarz S, Zakavi I. Effect of progressive resistance training on insulin resistance and plasma adiponectin concentration in overweight men. Jorjani Biomed J. 2019;7(1):51-64. [view at publisher] [Google Scholar]
24. Hulver MW, Zheng D, Tanner CJ, Houmard JA, Kraus WE, Slentz CA, et al. Adiponectin is not altered with exercise training despite enhanced insulin action. Am J Physiol Metab. 2002;283(4): 861-865. [view at publisher] [DOI] [PMID] [Google Scholar]
25. Clark CCT, Ghaedi E, Arab A, Pourmasoumi M, Hadi A. The effect of curcumin supplementation on circulating adiponectin: A systematic review and meta-analysis of randomized controlled trials. Diabetes Metab Syndr Clin Res Rev. 2019;13(5):2819-2825. [view at publisher] [DOI] [PMID] [Google Scholar]
26. Osali A. Aerobic exercise and nano-curcumin supplementation improve inflammation in elderly females with metabolic syndrome. Diabetol Metab Syndr. 2020;12(1):1-7. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
27. Abdolhamid Tehrani M. Study the Effect of Swimming Training and Curcumin on Reduction of BAX and P53 proteins and Increase in BCL2 protein in Heart Tissue of Rats During Withdrawal of Excessive Ethanol Consumption. Jorjani Biomed J. 2022; 4: 1-11. [view at publisher] [Google Scholar]
28. Salkovic-Petrisic M, Perhoc AB, Homolak J, Knezovic A, Osmanovic Barilar J, Riederer P. Experimental Approach to Alzheimer's Disease with Emphasis on Insulin Resistance in the Brain. Handb Neurotox. 2021;1-52. [view at publisher] [DOI] [Google Scholar]
29. Sedaghat H, Fattahi Bafghi A, Emami A. The effect of combined exercise training course with curcumin supplementation on lipid profiles of inactive middle-aged men. Iran J Diabetes Obes. 2018;10(2):61-6. [Google Scholar]

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