Volume 10, Issue 2 (5-2022)                   Jorjani Biomed J 2022, 10(2): 1-9 | Back to browse issues page


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Salehi O, kheirdeh M, Farkhaie F, noura M, Jamali Fashi R, Rakhshanizadeh A. The Effect of Interval and Continued Trainings with Citrus Aurantium on Pain Threshold and Motor Balance in Elderly Rats. Jorjani Biomed J 2022; 10 (2) :1-9
URL: http://goums.ac.ir/jorjanijournal/article-1-892-en.html
1- Department of Physical Education and Sport Sciences, University of Kurdistan, Sanandaj, Iran , omidreza.67salehi@gmail.com
2- Department of Physical Education, Sama Technical and Vocational College, Shiraz Branch, Islamic Azad University, Shiraz, Iran
3- Department of Physical Education and Sport Sciences, Najaf Abad Branch, Islamic Azad University, Najaf Abad, Iran
4- Department of Physical Education and Sport Sciences, Islamic Azad University, Shiraz Branch, Shiraz, Iran
5- Department of Physical Education and Sport Sciences, Sama Technical and Vocational College, Varamin Branch, Islamic Azad University, Varamin, Iran
6- Department of Physical Education and Sport Sciences, Payame Noor University, Iran
Abstract:   (3742 Views)

Background and objectives: Aging is a natural phenomenon associated with a decrease in physical fitness factors and increases in chronic pain. The present study aimed to investigate the effect of High Interval Intensity Training (HIIT) and Moderate Intensity Continued Training (MICT) with Citrus Aurantium (CA) consumption on pain threshold and motor balance in elderly rats.
Material and Methods: Forty-nine elderly rats were randomly divided into 1) control, 2) MICT, 3) HIIT, 4) MICT+CA, 5) HIIT+CA, 6) CA and 7) sham groups. Groups 3 and 5 performed HIIT at a speed of 25-25 m/min, and groups 2 and 4 performed MICT at a speed of 25-20 m/min; also, groups 4-6 received 300 mg/kg/day CA peritoneally. The pain and motor balance tests were evaluated using a hot plate and rotarod devices respectively. The Kolmogorov-Smirnov test was used to investigate the normal distribution of findings and one-way ANOVA with Tukey’s post- hoc tests was used to analyze of findings (P≤0.05).
Results: CA, MICT, HIIT, MICT+CA, and HIIT+CA significantly increased pain threshold and motor balance (P<0.05); MICT+CA (P<0.05) and HIIT+CA (P<0.05) significantly increased pain threshold compared to CA, MICT, and HIIT, and HIIT+CA significantly increased pain threshold compared to MICT+CA (P<0.05).
Conclusion: Although CA, MICT, and HIIT alone can enhance pain threshold and motor balance nevertheless it appears that MICT+CA and HIIT+CA have a better effect on the increase of pain threshold, so the effects of HIIT+CA can be higher than MICT+CA.


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 Aphthous stomatitis is a multifactorial disease, the exact cause has not yet been determine
 The interaction of exercise training and antioxidant supplements such as Citrus Aurantium has beneficial effects in improving neuromuscular function.

Type of Article: Original article | Subject: Health
Received: 2022/02/24 | Accepted: 2022/05/7 | Published: 2022/05/22

References
1. Wilkinson DJ, Piasecki M, Atherton PJ. The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans. Ageing Res Rev. 2018;47:123-32. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
2. Hosseini SA, Zar A, Darakhshandeh M, Salehi OR, Amiri R. The Effect of Volume and Intensity Changes of Exercises on Lipid Profile of Elderly Men. J Gerontol. 2017;1(4):38-46. [view at publisher] [DOI] [Google Scholar]
3. Kadoguchi T, Shimada K, Miyazaki T, Kitamura K, Kunimoto M, Aikawa T, et al. Promotion of oxidative stress is associated with mitochondrial dysfunction and muscle atrophy in aging mice. Geriatr Gerontol Int. 2019; [DOI] [PMID] [Google Scholar]
4. Sadeghimahalli N, Hosseini MA, Rahgozar M, Norouzi Tabrizi K. Locomotive syndrome in the elderly and its risk factors. 2019; [view at publisher] [DOI] [Google Scholar]
5. Aagaard P, Suetta C, Caserotti P, Magnusson SP, Kjær M. Role of the nervous system in sarcopenia and muscle atrophy with aging: strength training as a countermeasure. Scand J Med Sci Sports. 2010;20(1):49-64. [DOI] [PMID] [Google Scholar]
6. Chen D, Cao J, Zhu B, Wang Z, Wang T, Tang J. Baicalin attenuates joint pain and muscle dysfunction by inhibiting muscular oxidative stress in an experimental osteoarthritis rat model. Arch Immunol Ther Exp (Warsz). 2018;66(6):453-61. [view at publisher] [DOI] [PMID] [Google Scholar]
7. Liu Y, Chan JSY, Yan JH. Neuropsychological mechanisms of falls in older adults. Front Aging Neurosci. 2014;6:64. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
8. Distefano G, Goodpaster BH. Effects of exercise and aging on skeletal muscle. Cold Spring Harb Perspect Med. 2018;8(3):a029785. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
9. Papa E V, Dong X, Hassan M. Resistance training for activity limitations in older adults with skeletal muscle function deficits: a systematic review. Clin Interv Aging. 2017;12:955. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
10. Withee ED, Tippens KM, Dehen R, Tibbitts D, Hanes D, Zwickey H. Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial. J Int Soc Sports Nutr. 2017;14(1):24. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
11. Weihrauch M, Handschin C. Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls. Biochem Pharmacol. 2018;147:211-20. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
12. Merry TL, Ristow M. Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training? J Physiol. 2016;594(18):5135-47. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
13. Hosseini A, Sadeghnia HR, Rajabian A. Protective effects of peel and seed extracts of Citrus aurantium on glutamate-induced cytotoxicity in PC12 cell line. Folia Neuropathol. 2016;54:265-77. [view at publisher] [DOI] [Google Scholar]
14. Braidy N, Behzad S, Habtemariam S, Ahmed T, Daglia M, Mohammad Nabavi S, et al. Neuroprotective effects of citrus Fruit-Derived flavonoids, nobiletin and Tangeretin in Alzheimer's and Parkinson's Disease. CNS Neurol Disord Targets (Formerly Curr Drug Targets-CNS Neurol Disord. 2017;16(4):387-97. [view at publisher] [DOI] [PMID] [Google Scholar]
15. Cairncross L, Magee H, Askham J. A hidden problem: Pain in olde r people Picker Institute Europe. Oxford; 2007.
16. Kim J, Chakraborty S, Jayaprakasha GK, Muthuchamy M, Patil BS. Citrus nomilin down-regulates TNF-α-induced proliferation of aortic smooth muscle cells via apoptosis and inhibition of IκB. Eur J Pharmacol. 2017;811:93-100. [view at publisher] [DOI] [PMID] [Google Scholar]
17. Wei F, Hester AL. Gender difference in falls among adults treated in emergency departments and outpatient clinics. J Gerontol Geriatr Res. 2014;3:152. [view at publisher] [Google Scholar]
18. Gale CR, Cooper C, Aihie Sayer A. Prevalence and risk factors for falls in older men and women: The English Longitudinal Study of Ageing. Age Ageing. 2016;45(6):789-94. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
19. Davari F, Alimanesh Z, Alimanesh Z, Salehi O, Hosseini SA. Effect of training and crocin supplementation on mitochondrial biogenesis and redox-sensitive transcription factors in liver tissue of type 2 diabetic rats. Arch Physiol Biochem. 2020;1-6. [view at publisher] [DOI] [PMID] [Google Scholar]
20. Yazdanparast Chaharmahali B, Azarbayjani MA, Peeri M, Farzanegi Arkhazloo P. The Effect of Moderate and High Intensity Interval Training on Cardiac Apoptosis in the Old Female Rats. Rep Heal Care. 2018;4(1):26-35. [view at publisher] [Google Scholar]
21. He W, Li Y, Liu M, Yu H, Chen Q, Chen Y, et al. Citrus aurantium L. and its flavonoids regulate TNBS-induced inflammatory bowel disease through anti-inflammation and suppressing isolated jejunum contraction. Int J Mol Sci. 2018;19(10):3057. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
22. Hosseini SA. The effects of continued training and high intensity interval training along with Citrus aurantium on aerobic power, heart weight, adipose tissue weight and body weight of elderly rats. Jorjani Biomed J. 2020;8(4):17-25. [view at publisher] [Google Scholar]
23. Mallet PE, Beninger RJ, Flesher SN, Jhamandas K, Boegman RJ. Nucleus basalis lesions: implication of basoamygdaloid cholinergic pathways in memory. Brain Res Bull. 1995;36(1):51-6. [view at publisher] [DOI] [Google Scholar]
24. Lüesse H-G, Schiefer J, Spruenken A, Puls C, Block F, Kosinski CM. Evaluation of R6/2 HD transgenic mice for therapeutic studies in Huntington's disease: behavioral testing and impact of diabetes mellitus. Behav Brain Res. 2001;126(1-2):185-95. [view at publisher] [DOI] [Google Scholar]
25. Patti A, Bianco A, Karsten B, Montalto MA, Battaglia G, Bellafiore M, et al. The effects of physical training without equipment on pain perception and balance in the elderly: A randomized controlled trial. Work. 2017;57(1):23-30. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
26. Gordon R, Bloxham S. A systematic review of the effects of exercise and physical activity on non-specific chronic low back pain. In: Healthcare. Multidisciplinary Digital Publishing Institute; 2016. p. 22. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
27. Ambrose KR, Golightly YM. Physical exercise as non-pharmacological treatment of chronic pain: why and when. Best Pract Res Clin Rheumatol. 2015;29(1):120-30. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
28. Polaski AM, Phelps AL, Kostek MC, Szucs KA, Kolber BJ. Exercise-induced hypoalgesia: A meta-analysis of exercise dosing for the treatment of chronic pain. PLoS One. 2019;14(1). [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
29. Owen PJ, Miller CT, Mundell NL, Verswijveren SJJM, Tagliaferri SD, Brisby H, et al. Which specific modes of exercise training are most effective for treating low back pain? Network meta-analysis. Br J Sports Med. 2019; [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
30. Namazi M, Akbari SAA, Mojab F, Talebi A, Majd HA, Jannesari S. Effects of citrus aurantium (bitter orange) on the severity of first-stage labor pain. Iran J Pharm Res IJPR. 2014;13(3):1011. [view at publisher] [Google Scholar]
31. Heydari N, Abootalebi M, Tayebi N, Hassanzadeh F, Kasraeian M, Emamghoreishi M, et al. The effect of aromatherapy on mental, physical symptoms, and social functions of females with premenstrual syndrome: A randomized clinical trial. J Fam Med Prim care. 2019;8(9):2990. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
32. Mahmoud AM, Hernandez Bautista RJ, Sandhu MA, Hussein OE. Beneficial effects of citrus flavonoids on cardiovascular and metabolic health. Oxid Med Cell Longev. 2019;2019. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
33. Soudani N, Rafrafi M, Amara I Ben, Hakim A, Troudi A, Zeghal KM, et al. Oxidative stress-related lung dysfunction by chromium (VI): alleviation by Citrus aurantium L. J Physiol Biochem. 2013;69(2):239-53. [view at publisher] [DOI] [PMID] [Google Scholar]
34. Colker CM, Kaiman DS, Torina GC, Perlis T, Street C. Effects of Citrus aurantium extract, caffeine, and St. John's wort on body fat loss, lipid levels, and mood states in overweight healthy adults. Curr Ther Res. 1999;60(3):145-53. [view at publisher] [DOI] [Google Scholar]
35. Thirupathi A, Wang M, Lin JK, Fekete G, István B, Baker JS, et al. Effect of different exercise modalities on oxidative stress: a systematic review. Biomed Res Int. 2021;2021. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
36. Lu Y, Wiltshire HD, Baker JS, Wang Q. Effects of High Intensity Exercise on Oxidative Stress and Antioxidant Status in Untrained Humans: A Systematic Review. Biology (Basel). 2021;10(12):1272. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
37. Deshmukh NS, Stohs SJ, Magar CC, Kale A, Sowmya B. Bitter orange (Citrus aurantium L.) extract subchronic 90-day safety study in rats. Toxicol Reports. 2017;4:598-613. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]

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