Volume 9, Issue 2 (6-2021)                   Jorjani Biomed J 2021, 9(2): 1-4 | Back to browse issues page

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Khorasani M, Alaie M, Shojaee M. Role of Aberrant Alternative Splicing in Cancer. Jorjani Biomed J. 2021; 9 (2) :1-4
URL: http://goums.ac.ir/jorjanijournal/article-1-753-en.html
1- Department of Biochemistry and nutrition, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran , miladkh24@yahoo.com
2- Department of Clinical Biochemistry, Tarbiat Modares University, Tehran, Iran
3- Department of Biology, Payame Noor University of Mashhad, Iran
Abstract:   (364 Views)
Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biology and emphasize the necessity for conducting more research into target alternative splicing as a treatment for cancer.
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95% of human genes transcribe more than one transcript and generate variant protein isoforms tumors have irregular splicing pattern alternative splicing process are common occurrence and can be used as novel therapeutic biomarkers.
Type of Article: Letter to Editor | Subject: Molecular Sciences
Received: 2021/03/15 | Accepted: 2021/04/1 | Published: 2021/06/10

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