Volume 7, Issue 2 (7-2019)                   Jorjani Biomed J 2019, 7(2): 39-48 | Back to browse issues page


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Kheirollahi K, Hekmati Moghadam S H, Kabir G, Zare Mehrjardi Z. Evaluation of distribution of different species of Candida in cancer patients. Jorjani Biomed J. 2019; 7 (2) :39-48
URL: http://goums.ac.ir/jorjanijournal/article-1-663-en.html
1- Assistant Professor, Department of Oral Medicine, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Associate professor of pathology, Shahid Sadoughi University of medical Sciences, Yazd, Iran
3- postgraduated students, Department of Oral and maxillofacial surgery, Shahid Sadoughi University of Medical Science, Yazd, Iran
4- General dental practitioner, Faculty of Dentistry, Shahid Sadoughi University of Medical Science, Yazd, Iran , dents1395@gmail.com
Abstract:   (601 Views)
Background and objectives: patients undergoing Chemotherapy are severely susceptible to infections due to a compromised immune system and also their oral cavity is a great place for microorganisms and fungi to grow. The aim of this study was to determine the distribution of different strains of Candida from oral lesions of these patients.
Methods and Materials: This descriptive study was performed on 128 patients undergoing chemotherapy in teaching hospitals of Yazd, which was three weeks pass receiving their first medicine. Oral samples were prepared from swabs and then cultured in Sabouraud dextrose agar culture media for evaluation of yeast growth, colonization, and identification of species. Samples were examined under the microscope and recorded. Finally, the data were analyzed by SPSS17 software, Chi-square, and Man-Whitney tests.
Results:128 patients participated in this study, which included 45 males (35.15%) and 83 females (64.85%) with an average age of 40.16 ± 19.95 years. 84 patients (62.65%) had candida in their oral cavity, of which 79 were candida albicans and 5 were Non-albicans Candida. No significant correlation was found between the type of candidates, type of cancer and the frequency of Candida albicans with the age and sex of the patients (P-value <0.05).
Conclusion: Based on the results of this study, the prevalence of Candida albicans in patients undergoing chemotherapy is higher than Non-albicans Candida. Patients with leukemia are more susceptible to Candida infections.
Full-Text [PDF 328 kb]   (195 Downloads)    
Type of Article: Original article | Subject: General medicine
Received: 2019/09/21 | Revised: 2020/01/27 | Accepted: 2019/10/2

References
1. Miller A, Hoogstraten B, Staquet M, Winkler A. Reporting results of cancer treatment. cancer 1981;47(1):207-214. [DOI] [Google Scholar]
2. Yoosefian-Miandoab N, Ezzati ZH, Arbabi F, Manoochehri H, Zayeri F. The effect of reflexotherapy on chemotherapy-induced vomiting of patients Faculty of Nursing of Midwifery Quarterly 2012;22(76):60-68. [Google Scholar]
3. Organization WH. National cancer control programmes: policies and managerial guidelines: World Health Organization; 2002. [Google Scholar]
4. Stewart BW, Wild CP. World cancer report 2014. The Health Well.[January 17th, 2017]. URL: http://www. thehealthwell. info/node/725845. [Google Scholar]
5. Iwamoto T. Clinical application of drug delivery systems in cancer chemotherapy: review of the efficacy and side effects of approved drugs. Biological and Pharmaceutical Bulletin 2013;36(5):715-718. [DOI] [Google Scholar]
6. Teillant A, Gandra S, Barter D, Morgan DJ, Laxminarayan R. Potential burden of antibiotic resistance on surgery and cancer chemotherapy antibiotic prophylaxis in the USA: a literature review and modelling study. The Lancet infectious diseases 2015;15(12):1429-1437. [DOI] [Google Scholar]
7. Mirabile A, Numico G, Russi EG, Bossi P, Crippa F, Bacigalupo A, et al. Sepsis in head and neck cancer patients treated with chemotherapy and radiation: literature review and consensus. Critical reviews in oncology/hematology 2015;95(2):191-213. [DOI] [Google Scholar]
8. Wong HM. Oral complications and management strategies for patients undergoing cancer therapy. The Scientific World Journal 2014;2014. [DOI] [Google Scholar]
9. Arab H, Sargolzaee N, Moeintaghavi A. Periodontal considerations in chemotherapy of patients with head and neck cancers. J Dent Sch 2007;24(4):469-73.
10. da Cruz Campos MI, Neiva Campos C, Monteiro Aarestrup F, Vieira Aarestrup BJ. Oral mucositis in cancer treatment: Natural history, prevention and treatment (Review). Molecular and clinical oncology 2014;2(3):337-340. [DOI] [Google Scholar]
11. Kurnatowski P, Moqbil S, Kaczmarczyk D. Signs, symptoms and the prevalence of fungi detected from the oral cavity and pharynx of radiotherapy subjects with head and neck tumors, and their susceptibility to chemotherapeutics. Ann Parasitol 2014;60(3):207-13. [Google Scholar]
12. Brooks GF, Carroll KC, Butel JS, Morse SA. Jawetz, Melnick, Adelberg Medical Microbiology. 24 th ed. Michigan: McGraw-Hill Medical; 2007.
13. Kazemi A, Nowrozi H, Badiee-Moghadam M. Drug susceptibility testing of clinical isolates of Candida albicans against Amphotericin B and Ketoconazole by microdilution and disk diffusion methods. Journal of Gorgan University of Medical Sciences 2017;19(2):59-64. [Google Scholar]
14. Gentle TA, Warnock DW, Eden OB. Prevalence of oral colonization with Candida albicans and anti-C. albicans IgA in the saliva of normal children and children with acute lymphoblastic leukaemia. Mycopathologia 1984;87(1-2):111-4. [DOI] [Google Scholar]
15. Maheronnaghsh M, Tolouei S, Dehghan P, Chadeganipour M, Yazdi M. Identification of Candida species in patients with oral lesion undergoing chemotherapy along with minimum inhibitory concentration to fluconazole. Adv Biomed Res 2016;5:132. [DOI] [Google Scholar]
16. Arendorf TM, Walker DM. The prevalence and intra-oral distribution of Candida albicans in man. Arch Oral Biol 1980;25(1):1-10. [DOI] [Google Scholar]
17. Katiraee F, Khosravi AR, Khalaj V, Hajiabdolbaghi M, Khaksar AA, Rasoulinejad M. In vitro antifungal susceptibility of oral candida species from Iranian HIV infected patients. Tehran University Medical Journal 2012;70(2):96-103. [Google Scholar]
18. Safdar A, Armstrong D. Infectious morbidity in critically ill patients with cancer. Crit Care Clin 2001;17(3):531-70, vii-viii. [DOI] [Google Scholar]
19. Teoh F, Pavelka N. How Chemotherapy Increases the Risk of Systemic Candidiasis in Cancer Patients: Current Paradigm and Future Directions. Pathogens 2016;5(1). [DOI] [Google Scholar]
20. Yogitha PVV, Lakshmi N, Lakshmi KR, Krishna PBM, Cheemala SS. Isolation and speciation of genus candida in patients undergoing chemotherapy and radiotherapy for head and neck tumours. 2017 2017;3(5):6. [DOI] [Google Scholar]
21. Vanden-Abbeele A, De Meel H, Ahariz M, Perraudin JP, Beyer I, Courtois P. Denture contamination by yeasts in the elderly. Gerodontology 2008;25(4):222-8. [DOI] [Google Scholar]
22. Ramla S, Sharma V, Patel M. Influence of cancer treatment on the Candida albicans isolated from the oral cavities of cancer patients. Support Care Cancer 2016;24(6):2429-36. [DOI] [Google Scholar]
23. Byadarahally Raju S, Rajappa S. Isolation and identification of Candida from the oral cavity. ISRN Dent 2011;2011:487921. [DOI] [Google Scholar]
24. Jones JM. Laboratory diagnosis of invasive candidiasis. Clin Microbiol Rev 1990;3(1):32-45. [DOI] [Google Scholar]
25. Bassetti M, Merelli M, Ansaldi F, de Florentiis D, Sartor A, Scarparo C, et al. Clinical and therapeutic aspects of candidemia: a five year single centre study. PLoS One 2015;10(5):e0127534. [DOI] [Google Scholar]
26. Ortega M, Marco F, Soriano A, Almela M, Martinez JA, Lopez J, et al. Candida species bloodstream infection: epidemiology and outcome in a single institution from 1991 to 2008. J Hosp Infect 2011;77(2):157-61. [DOI] [Google Scholar]
27. Guinea J. Global trends in the distribution of Candida species causing candidemia. Clin Microbiol Infect 2014;20 Suppl 6:5-10. [DOI] [Google Scholar]
28. Davies AN, Brailsford S, Broadley K, Beighton D. Oral yeast carriage in patients with advanced cancer. Oral Microbiol Immunol 2002;17(2):79-84. [DOI] [Google Scholar]
29. Humada TA. Oral Candidiasis in Cancer Patients undergoing chemotherapy. Tikrit Medical Journal 2013;19(1):10-20. [Google Scholar]
30. Maccallum DM. Hosting infection: experimental models to assay Candida virulence. Int J Microbiol 2012;2012:363764. [DOI] [Google Scholar]
31. Al-Abeid HM, Abu-Elteen KH, Elkarmi AZ, Hamad MA. Isolation and characterization of Candida spp. in Jordanian cancer patients: prevalence, pathogenic determinants, and antifungal sensitivity. Jpn J Infect Dis 2004;57(6):279-84. [Google Scholar]
32. DiNubile MJ, Hille D, Sable CA, Kartsonis NA. Invasive candidiasis in cancer patients: observations from a randomized clinical trial. J Infect 2005;50(5):443-9. [DOI] [Google Scholar]
33. Uzun O, Anaissie EJ. Predictors of outcome in cancer patients with candidemia. Ann Oncol 2000;11(12):1517-21. [DOI] [Google Scholar]
34. Pagano L, Akova M, Dimopoulos G, Herbrecht R, Drgona L, Blijlevens N. Risk assessment and prognostic factors for mould-related diseases in immunocompromised patients. J Antimicrob Chemother 2011;66 Suppl 1:i5-14. [DOI] [Google Scholar]

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