Medical Laboratory Journal
Medical Laboratory Journal
mljgoums
Medical Sciences
http://mlj.goums.ac.ir
1
admin
2538-4449
10.52547/mlj
en
jalali
1395
2
1
gregorian
2016
5
1
10
3
online
1
fulltext
fa
Comparison of Epicardial Adipose Tissue Fatty Acid Profile in Cardiovascular Disease Patients Diabetic and Non-Diabetic
تحقيقي
Original Paper
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<p><strong>ABSTRACT</strong></p>
<p><strong> Background and Objective:</strong> The relationship between diabetes mellitus and increased risk of cardiovascular diseases has been demonstrated. The aim of this study was to determine the fatty acid profile of epicardial adipose tissue in diabetic and non-diabetic patients with cardiovascular disease.</p>
<p><strong> Methods:</strong> In this study, 28 diabetic and 40 nondiabetic patients were evaluated. The epicardial adipose tissue and blood samples of patients were collected during surgery. Non‐esterified fatty acids and phospholipids were measured by the thin layer chromatography and gas chromatography.</p>
<p><strong> Results:</strong> Saturated free fatty acids (12: 0) level was higher in diabetic patients compared to nondiabetic patients (P=0.038), while saturated free fatty acids (16: 0) was significantly lower in diabetics (P=0.011). Unsaturated fatty acid (20: 3n-9) was higher in nondiabetics compared to diabetics (P=0.015). There was a significant decrease in level of monounsaturated fatty acids in diabetic patients. The epicardial adipose tissue of diabetics showed a significant increase in free fatty acid (18: 0) and conjugated linoleic acid levels, while there was a significant decrease in the level of free fatty acid (18: 1n-11). Level of epicardial omega-3 free fatty acid (20: 5 n-3) and 22: 6 n -3 was significantly reduced in these patients.</p>
<p><strong> Conclusion:</strong> Differences in the serum free fatty acid profile of the two groups may be due to differences in their diet, while changes in the fatty acid composition of epicardial adipose tissue in these two groups could be due to impaired metabolism of fatty acids such as uptake, movement and androgen synthesis as a result of diabetes. These changes increase the risk of developing atherosclerosis in diabetic patients.</p>
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Diabetes Mellitus, Adipose Tissue, Atherosclerosis, Cardiovascular Disease.
13
20
http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-399&slc_lang=fa&sid=1
Seyyed Manuchehr
Nourazarian
100319475328460010769
100319475328460010769
No
Department of Laboratory Sciences
Mojtaba
Ghaffarian
100319475328460010770
100319475328460010770
No
Department of Molecular Biology
Homayun
Dolatkhah
dolatkhahh@gmail.com
100319475328460010771
100319475328460010771
Yes
Department of Clinical Biochemistry and Laboratoris Medicine