fa غلظت فرم محلول گیرنده فاکتور رشد هپاتوسیت در مایع مغزی- نخاعی و سرم بیماران مبتلابه مننژیت باکتریایی و ویروسی تحقيقي Original Paper Abstract Background and objectives: C-Met is a proto-oncogene that encodes a protein known as hepatocyte growth factor receptor (HGFR). The HGF receptor possesses tyrosine -kinase activity and it is essential for embryonic development, wound healing and cancer. Many proteins are proteolytically released from the surface by a process known as ectodomain shedding. Shedding occurs under normal physiologic conditions and can be increased in certain pathologies. C-Met can be seen among many receptors for which ectodomain shedding has been shown. The aim of this study was to determine the concentration of soluble c-Met in the cerebrospinal fluid (CSF) and serum samples of patients with viral and bacterial meningitis. Material and Methods: in this study, 75 CSF and serum samples of patients with bacterial meningitis, 71 with viral meningitis and 82 normal controls were investigated. The soluble c-Met concentration was determined by enzyme linked immunosorbent assay (ELISA). Result: the amount of soluble c-met in CSF of patients with bacterial meningitis ( 83.91±5.50), viral meningitis ( 80.41±4.71) and control group ( 22.66±3.39) are compared with that in serum of patients with bacterial meningitis ( 561.58±25.87), viral meningitis ( 550.50 ±34.34) and control group ( 256.25±18.55). There is significant increase in the CSF and serum’s soluble c-Met expression in the patients with meningitis, in comparison with control group. Conclusion: The data presented here indicate that soluble c-Met is a constant component of human serum and CSF, but it can not be used for differentiating bacterial meningitis from viral meningitis. Key words: Soluble c-Met, concentration, cerebrospinal fluid, serum, meningitis Soluble c-Met, concentration, cerebrospinal fluid, serum, meningitis 1 6 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-112&slc_lang=fa&sid=1 Khoshdel Rad N نیلوفر خوشدل راد 100319475328460013461 100319475328460013461 No Master student, Department of Biology, گروه زیست شناسی دانشکده علوم Mashayekhi F فرهاد مشایخی mashayekhi@guilan.ac.ir 100319475328460013462 100319475328460013462 Yes Associate Professor Department of Biology, دانشیار گروه زیست شناسی، دانشکده علوم Mirzajani E ابراهیم میرزاجانی 100319475328460013463 100319475328460013463 No Assistant Professor of Cellular and Molecular Research Center استادیار مرکز تحقیقات علوم سلولی و مولکولی، دانشکده پزشکی