Showing 4 results for Uda
Huda Jomma Elkheer Jomma, Mohmmed Omer Abaker Gibreel,
Volume 11, Issue 2 (3-2017)
Abstract
ABSTRACT
Background and Objective: This descriptive study aimed to evaluate the presence and frequency distribution of mosquito species in the city of Port Sudan, Sudan.
Methods: After collection of 500 adult mosquitoes from different sectors of the city Port Sudan, they were classified using the morphological keys for identification of mosquitoes.
Results: Overall, 230
Culex quinquefasciatus (46%) were detected in the eastern, central and southern sectors of the city.
Culex sitiens (14.2%) were detected only in the central sector.
Aedes aegypti (32.2%) were detected in all three sectors.
Anopheles funestus (6.6%) were detected in the central and southern sectors.
Conclusion: Cx. quinquefasciatus and
Ae. aegypi are prevalent in all sectors of the city, while
Cx. sitiens is prevalent only in the central sector.
An. funestus is abundant in the central and southern sectors.
Keywords: Culicidae,
Morphological and Microscopic Findings, Eastern Sudan.
Manasa Sireesha Devara, Sriushaswini Bhamidipati, Vijaya Bharathi Dondapati , Narasinga Rao Bandaru,
Volume 17, Issue 6 (11-2023)
Abstract
Background: Medicinal plants have played crucial roles in the traditional health care system since the origin of mankind. Among them, cinnamon is used not only as a spice in food but also as a substance with many health-beneficial effects. The aim of the present study was to identify the antibacterial activity of cinnamon bark extract against bacterial isolates from patient pus samples that might help treat infections.
Methods: The antibacterial potential of cinnamon bark extract in both ethanol and methanol against 6 bacterial isolates obtained from pus samples received in the Microbiology Laboratory was identified by agar well diffusion, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) using standard techniques.
Results: By agar well diffusion, the highest inhibitory activity of ethanol and methanol extracts of cinnamon was shown by Staphylococcus aureus, followed by coagulase-negative Staphylococci. The lowest inhibitory effect was shown by Proteus mirabilis. The ethanol extract of cinnamon MIC and MBC ranged from 6.25 mg/mL to 12.5 mg/mL and 12.5 mg/mL to 50 mg/mL. The methanol extract of cinnamon MIC showed a value of 12.5 mg/mL, and the methanol extract of MBC ranged from 12.5 mg/mL to 50 mg/mL against all bacterial isolates of the present study.
Conclusion: Staphylococcus aureus is sensitive to the alcoholic extract of cinnamon bark, but its effect is less than that of the selected antibiotic.
Zarifeh Akbari , Dara Dastan , Mohammad Fallah , Amir Hossein Maghsood , Mohammad Matini ,
Volume 19, Issue 6 (11-2025)
Abstract
Background: Trichomonas vaginalis (T. vaginalis) causes human trichomoniasis, a common type of protozoan vaginitis. Due to the increasing incidence of drug-resistant trichomoniasis, new pharmacological research is needed. The aim was to investigate the activity of Ferula pseudalliacea (F. pseudalliacea) against T. vaginalis and to perform a preliminary phytochemical analysis of its extracts.
Methods: Essential oil and various extracts of F. pseudalliacea roots, including n-hexane, ethyl acetate, and methanol, were obtained. Susceptibility testing of the plant products was performed on five T. vaginalis isolates using the microtiter plate method. Minimum lethal concentration (MLC) and growth inhibitory percent (GI%) of sub-MLC concentrations were reported after 24- and 48-hour exposures. Phytochemical screening of the extracts was carried out using a standard procedure.
Results: The antitrichomonal effect of the plant products depended on time and concentration, with the greatest effect observed after 48 hours of exposure. The essential oil and n-hexane extract of F. pseudalliacea demonstrated remarkable activity with MLC of 250 µg/ml, followed by the ethyl acetate (MLC=500 µg/ml) and methanol extract (MLC=1000 µg/ml), with GI% 92.8, 50.6, 85.2, and 42.8, respectively. The bioactive constituents of the extracts were coumarins, terpenoids, steroids, phenols, tannins, and glycosides.
Conclusion: The results of this study demonstrated in vitro antitrichomonal properties of F. pseudalliacea. Therefore, further studies are needed to investigate the potential antitrichomonal activity of its bioactive constituents.
Esmail Samadian, Arash Golalipour, Mohammadali Vakili, Hasan Mohammed, Azam Rashidbaghan,
Volume 20, Issue 2 (6-2026)
Abstract
Background: The high global mortality of breast cancer in women necessitates novel therapies with fewer side effects.. Urtica dioica agglutinin (UDA), a lectin from stinging nettle, exhibits antiproliferative properties in various cancers, but its effect on breast cancer cells remain underexplored. This study evaluates UDA’s cytotoxic potential against Michigan Cancer Foundation-7 (MCF-7) breast cancer cells while assessing its impact on non-tumorigenic human mammary epithelial (MCF-10A) and Human embryonic kidney (HEK-293) cells.
Methods: UDA purification was performed via affinity chromatography from Urtica dioica rhizomes, confirmed by SDS-PAGE (8.5–9.5 kDa) and agglutination assays. MCF-7, MCF-10A, and HEK-293 cells were treated with different concentrations of UDA (7.5–480 µg/ml) for 24 and 48 hours. Cytotoxicity was assessed using MTT assays to measure cell viability.
Results: UDA significantly inhibited MCF-7 proliferation in a dose- and time-dependent manner (P < 0.01 at 24 hours; P < 0.0001 at 48 hours). At 240 µg/ml (during 48 hours), viability dropped below 50%, while normal HEK-293 cells showed <30% toxicity. MCF-10A proliferation remained unaffected, even at 480 µg/ml. IC50 was 389.7 207.0 μg/mL for 24 and 48 hours.
Conclusion: UDA targets breast cancer cells (MCF-7) with minimal toxicity to normal cells, positioning it as a promising anticancer candidate. Determining the mechanism of its action and apoptosis-inducing potential needs further research in the future. .
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