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Showing 2 results for Cervical Cancer
Cytotoxic Effect of Boswellia Serrata Hydroalcholic Extract on Human Cervical Carcinoma Epithelial Cell Line
S Forouzandeh, N Naghsh, S Salimi, D Jahantigh,
Volume 8, Issue 1 (4-2014)
Abstract
Abstract Background and Objective: Cervical cancer is the second most common cancer in women. Boswellia serrata is a medicinal herb with anticancer, antibacterial, antiulcer, antifungal properties. Since the antitumor effect of this medicine has not been studied on cancer cell lines, we aimed to investigate the antitumor effect of Boswellia serrata on cervical cancer cell lines. Material and Methods: To assess the anti-cancer effect of Boswellia serrata extract, HeLa cell lines were cultured , propagated and placed with different doses of Boswellia serrata (12.5,25, 50 and100 µg/ml) for 24,48and72 hours. After that, MTT test was used to determine the cellular toxicity of the extract. Results: The results of the MTT test showed that this extract has dose-dependent and time-dependent anti cancer effect on Hela in that the highest effect was seen with 100 µg/ml of extract for 72 hrs. The half maximal inhibitory concentration (IC50) for 24 and 48 hrs were 12.5 and 50 µg/ml, respectively. In 72 hours, due to increase of incubation period in all concentrations, the number of killed cells was more than 50 percent. Consequently, IC50 was not observed for this period of time. Conclusion: Considering dose-dependent and time-dependent anti cancer effect, Boswellia serrata extract can inhibit the growth of Hela cells. Keywords: Hela Cell MTT Test Boswellia Serrata Extract Cervical Cancer
Self-sampling for cervical cancer screening: preferences, acceptability, convenience and cost-effectiveness
Sedigheh Damavandi Kamali , Iliad Moradi , Abdolvahab Moradi ,
Volume 18, Issue 6 (11-2024)
Abstract
Background: Human papillomaviruses (HPVs) are DNA viruses from the Papillomaviridae family. These viruses are linked to about 5% of human cancers, with a significant association with cervical cancer. Infection with this virus can be screened in women to prevent cervical cancer.
Methods: This review analyzes articles published over the last two decades regarding self-sampling, papillomavirus, and cervical cancer. The search for articles was conducted using various scientific databases, with selections based on their relevance to the topic and their contribution to understanding and comparing methods. Key results were examined, focusing on social aspects, economic savings, and participants' satisfaction with the self-sampling method.
Results: One of the most common and effective methods for HPV screening is sampling from the cervix using the Pap smear method and molecular techniques, widely used in various countries. Currently, HPV screening methods in different countries are primarily limited to clinical sampling, which cannot cover all urban and rural populations. The World Health Organization has recommended and supported self-sampling for HPV screening as a new strategy.
Conclusion: This mini-review discusses the self-sampling method for HPV screening, its advantages, and its application in different countries. As self-sampling can address the needs of both rural and urban areas, it is more economically viable and helps minimize cultural barriers and public opinion challenges compared to clinical sampling. The HPV self-sampling strategy offers an effective and efficient method for HPV screening, aiming to cervical cancer caused by the HPV virus in various countries.

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