H Rahimzadeh, M Kargar, Y Dadban, S Birami,
Volume 1, Issue 2 (10-2007)
Abstract
Abstract Background and Objectives: Fluoride is one of the anions existed in water and soil. Its amount is not the same in different kind of water. Since the most of body's need to fluoride should be provided by drinking water, this study was aimed at determining the fluoride level in water supply of Gorgan rural regions. Materials and Methods: In this Cross-Sectional study, the subjects were all 67 water sources of the region. Every season, a one litter Sample was taken in a plastic Container and tested by SPADS Method. After Collecting and encoding the data, ANOVA was used to analyze. Results: The Findings shows that there are 4 springs and 63 wells which are Located in the mountainous (N=16) and flat (N= 47) regions. In every season, the average fluoride Level was lower than Standard Level (1.5 mg/L). The difference between fluoride Level of wells (0.39±0.15mg/L) and springs (0.16± 0.13mg/L) is Significant (p<0.05) the fluoride Level of mountainous wells is higher than wells located in flat regions (0.13mg/L). This deference was Significant (p<0.05). Conclusion: Based on The results revealing the fluoride Level of drinking water in Gorgan Rural region is less than international Standard, we recommend adding of Supplementary fluoride in foodstuffs of The people Living in This region. Key words: fluoride, drinking water resources, Gorgan, spring
Minoo Mahmoodi , Mozhgan Zeini, Siamak Shahidi,
Volume 11, Issue 4 (7-2017)
Abstract
ABSTRACT
Background and Objectives: Hippocampus is the main structure involved in spatial learning and memory consolidation. Formation of spatial memory can be strongly influenced by medications, hormones and different substances. Due to importance of new pharmacotherapy on drug administration in pregnancy, the aim of this study was to investigate the effect of letrozole-therapy during pregnancy on memory and learning in offspring rats.
Methods: In this study, 24 pregnant rats were divided into a control and three experimental groups (N=6). The subjects received low dose (0.25 mg/Kg), average dose (0.5 mg/Kg) and high dose (1 mg/Kg) of letrozole orally during 16-19 days of gestation. After maturating, learning and memory of the offspring were assessed by passive avoidance learning apparatus. Data were analyzed by SPSS 20 using one-way analysis of variance and the Tukey's test. P-values less than 0.05 were considered statistically significant.
Results: Weights of the offspring who received letrozole decreased significantly compared with the control. There was no significant difference in the step-through latency between the experimental groups. However, the step-through latency and time spent in the dark compartment decreased significantly in the experimental groups compared with control group (P<0.05).
Conclusion: The results of this study show that letrozole can influence learning and memory of offspring rats.
Keywords: Letrozole, Gestation, Memory, Learning, Offspring, Rats.
