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Showing 3 results for Pulmonary Tuberculosis

Pourhajibagher M ( Msc), Nasrollahi M(phd),
Volume 5, Issue 1 (4-2011)
Abstract

Abstract Background and objectives: Direct smear microscopy, because of its simplicity, rapidity, low cost and relatively sensitive is a suitable method to detecting pulmonary tuberculosis. This experiment was aimed at determining the best method for detecting Mycobacterium tuberculosis among three kinds of staining methods: Fluorochrome, Ziehl Neelsen and Tan Thiam Hok . Material and Methods: The sputum specimens (N=714) were obtained from people with suspected pulmonary tuberculosis and identified by three staining procedures. We determined the sensitivity, specificity, and the positive and negative predictive value of them and compared results by growth on Lowenstein-Jensen medium as gold standard. Results: Ninety-three (13%) of 714 sputum specimens were positive in culture method. The sensitivity of Tan Thiam Hok, Ziehl Neelsen and Fluorochrome are 89.2%, 91.3% and 95.6%, respectively, while their specificity and positive predictive value were 100%. Their negative predictive values were 98.3%, 98.7 %, 99.3 %, respectively. Conclusion: We conclude that Ziehl Neelsen can still be a reliable procedure for detecting AFB in sputum specimens because it has the appropriate sensitivity and specificity in comparison with another method of staining. Key words: pulmonary tuberculosis, Tan Thiam Hok staining, Ziehl-neelsen staining , Flurochrome staining
Semira Kheiri , Zohreh Nematollahi, Naghmeh Gholipour, Jahanbakhsh Asadi,
Volume 12, Issue 3 (5-2018)
Abstract

ABSTRACT
          Background and Objectives: Mycobacterium tuberculosis is the causative agent of pulmonary tuberculosis, a main public health problem that results in 1.5 million deaths annually. A number of epidemiological studies suggested that host genetic factors could play a main role in susceptibility to tuberculosis infection.
SP110 is an interferon-induced nuclear body protein with vital roles in apoptosis, cell cycling and immunity. SP110 gene has been suggested to be a suitable candidate for limiting TB infections. Thus, we investigated the possible association between SP110 gene polymorphisms and susceptibility to tuberculosis in the Golestan Province, Iran.
          Methods: We investigated the frequency of rs1135791 polymorphism of the SP110 gene among 100 pulmonary tuberculosis patients and 100 healthy individuals who were referred to the health centers in the Golestan Province (Iran) between 2014 and 2015. Frequency of genotypes was evaluated using amplification refractory mutation system-polymerase chain reaction.
          Results: The frequency distribution of TT, TC and CC genotypes among the patients was 65%, 31% and 4%, respectively. In the control group, the frequency distribution of TT, TC and CC genotypes was 56%, 46% and 7%, respectively. There was no significant difference in the frequency of rs1135791 between the patients with pulmonary tuberculosis and the healthy controls (P=0.42).
          Conclusion:  Based on the results, the SP110 rs1135791 variant is not a genetic risk factor for development of pulmonary tuberculosis in Golestan Province, Iran.
          Keywords: rs1135791T, Pulmonary tuberculosis, Golestan Province.

Alireza Nikonajad, Sadegh Ali Azimi, Abbas Allami, Reza Qasemi Bargi, Alijan Tabarraei,
Volume 15, Issue 1 (1-2021)
Abstract

Objectives: Although extrapulmonary tuberculosis (EPTB) is a secondary target for national TB control programs, its significance has increased worldwide. In order to study the epidemiology of EPTB in the Northeast of Iran, this survey was conducted.
Methods and Methods: A population-based, retrospective analysis of all cases of EPTB during 2012–2015 reported to the TB Unit of the Golestan was performed. Socioeconomic and environmental variables, sites, admission, mode of diagnosis and outcome status were collected. Data analyzed through SPSS 25.0 by descriptive and analytical statistical methods.
Results: A total of 741 cases of EPTB were included. Patients were mainly female (59.1%), age of 0 to 40 years old (57.6%), less than five years of education (46.7%) and mainly Fars (39.6%). Non-native ethnicities significantly acquired EPTB more than native ethnicities (p<0.001). Mortality rate was 5.1%. Smoking detected more frequently in EPTB patients (p<0.001). HIV status of most EPTB patients (89.3%) were unknown. The most common forms were pleural (30.5%) and lymphadenopathy (22.0%). Cultures and PCR performed in only about 10 percent of EPTB patients in our study.
Conclusions: EPTB was more prevalent in non-native population. Improvement of socioeconomic conditions and screening program may be successful in reducing the problem among immigrant

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