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P Farzanegi, Pp Ayatollahi, Ar Barari, M Fakori Joybari, S Shirali, M Shojaee, A Khandandel,
Volume 8, Issue 2 (summer 2014[PERSIAN] 2014)

Abstract Background and Objective: Imbalance Between antioxidant defensive system and increased production of free radicals leads to oxidative stress that can be effective in making cellular damage and causing some diseases such as diabetes. The aim of the current study was to investigate the effect of eight-week purslane extract consumption on some peroxidant and antioxidants indicators in patients with type 2 diabetes. Material and Methods: The Participants were 16 women with type 2 diabetes who had not the history of once a week regular physical activity program, in previous five years. They were randomly divided into two groups of experimental, purslane supplementation for eight weeks, and control. Blood sampling was performed in two stages. Results: After eight weeks of purslane consumption, resting levels of MDA, SOD and CAT in Supplementation group showed a significant decrease compared to those of control group. Conclusion: Purslane consumption can improve peroxidant/antioxidant balance in women with type2 diabetes. Key words: Purslane, Peroxidant Balance, Antioxidant, Type 2 Diabetes
Al Barari, Aa Ayatollahi, S Shirali, M Ghasemi, A Hosseini, Ar Ekrami, A Khandan Del,
Volume 8, Issue 3 (Autumn[PERSIAN] 2014)

Abstract Background and Objective: The hormonal responses are different, according to type, intensity and the duration of training. We aimed to compare the effect of endurance and resistance training in untrained men on the level sexual hormone including testosterone, estradiol, and on sex hormone binding globulin (SHBG). Material and Methods: this study was conducted on male Student Volunteers divided randomly into three groups of eight members, including endurance, resistance and control. To measure the variables, we performed sampling before and after the training program. Results: the levels of testosterone and estradiol, in both groups have a significant (p<0.05) increase and decrease respectively. SHBG level was significantly increased only in endurance group (p<0.05), But LH level was meaningfully increased only in the resistance group (p<0.05). Conclusion: The endurance and resistance training can increase the production of testosterone .Increased testosterone and decreased estradiol in men lead to sperm production and improve fertility. Keywords: Endurance training, Resistance Training, Testosterone, Estradiol
Ali Reza Barari ,
Volume 10, Issue 4 (Jul-Aug 2016 2016)


        Background and Objective: Exercise training and supplementation have different effects on the immune system. The aim of the present study was to evaluate the effect of ginger supplementation and endurance training on serum levels of Interleukin 1 alpha (IL1α) and tumour necrosis factor α (TNFα) in untrained young women.

        Methods: The study was performed on 32 untrained young women with mean age of 30±2 years from city of Abbas Abad, in 2014. The participants were randomly assigned into four groups of endurance training (E), endurance training and ginger supplementation (EG), ginger supplementation (G) and control (C). Endurance training was performed at 60-70% heart rate reserve for six weeks, three times a week, and for 60 minutes per session. Daily supplementation with 10 mg/Kg/day of ginger extract was carried out. T-test and ANOVA were used to evaluate the effect of independent variables, and make comparisons between the groups.

          Results: The mean level of IL-1α decreased significantly after the training period in the G and EG groups. There were significant differences between E and EG groups and EG and C groups. The results of intergroup comparison showed that the mean levels of TNFα decreased significantly after the training in the E, G and EG groups. There were significant differences between E and EG groups, E and G groups, EG and C groups, and G and C groups.

         Conclusion: Ginger consumption and adaptation to endurance training can counteract the negative effects on immune function and stability of mast cell membrane.

          Keywords: Endurance Training, Ginger, IL-1alpha and TNF-alpha.

Alireza Barari, Faeghe Dehghani Pour, Ahmad Abdi, Parvin Farzanegi,
Volume 14, Issue 2 (Mar-Apr 2020)

Background and objectives: Nonalcoholic fatty liver disease (NAFLD) is a chronic hepatic disease characterized by fat accumulation inside hepatocytes. The aim of this study was to evaluate effects of exercise training and resveratrol supplementation on activin A and follistatin levels in rats with NAFLD under a high-fat diet.
Methods: Fifty-six old (40-50 weeks) male Wistar rats were assigned to a healthy control group and seven experimental NAFLD groups: 1. high-fat diet, 2. saline, 3. resveratrol supplementation, 4. continuous exercise, 5. interval exercise, 6. continuous exercise+ resveratrol supplementation and 7. interval exercise+ resveratrol supplementation. Rats in the resveratrol supplementation groups were given 25 mg/kg of body weight intraperitoneal injection of resveratrol daily. Exercises were performed five days a week for eight weeks. Data were analyzed with SPSS (version 21) using one-way analysis of variance (ANOVA) and Tukeychr('39')s post hoc test at significance of 0.05.
Results: Exercise training and resveratrol supplementation significantly decreased plasma activin A level and increased activin A expression (P<0.05). Plasma level of follistatin was significantly higher in rats under a high-fat diet compared to healthy control animals. All exercise and supplementation groups alone and combined lowered follistatin levels. However, follistatin mRNA expression increased significantly after resveratrol supplementation alone, continuous exercise+ resveratrol supplementation, and interval exercise+ resveratrol supplementation.
Conclusion: Resveratrol has a beneficial effect on activin A and follistatin levels in rats with NAFLD. In addition, resveratrol supplementation combined with exercise training may have greater health benefits for NAFLD patients compared to resveratrol supplementation or exercise training alone.
Keywords: Exercise, Resveratrol, Activin A, Follistatin, Nonalcoholic Fatty Liver Disease.

Aghil Sadighi, Ahmad Abdi, Mohammad Ali Azarbayjani, Alireza Barari,
Volume 15, Issue 1 (Jan-Feb 2021)

Background and objectives: Cardiac apoptosis is one of the most important cardiovascular complications of diabetes. We aimed to investigate the changes of Bax, Bcl2 and caspase 3 in cardiac tissue of diabetic rats after six weeks aerobic exercise.
Methods: Thirty two male Wistar rats were randomly divided into healthy control, diabetes control and diabetes + exercise groups. Diabetes was induced by intraperitoneal injection of streptozotocin solution (55 mg/kg). Two weeks after the injection, fasting blood glucose levels were measured to confirm induction of diabetes. The exercise program was performed five days a week for six weeks. Variables were evaluated by ELISA and western blot analysis. All statistical analyses were performed in SPSS (version 22) using ANOVA and at significance of 0.05.
Results: The induction of diabetes in the control groups resulted in a significant increase in Bax, Bax/Bcl2 ratio and a significant decrease in Bcl2 levels (P=0.024). The six-week training exercise in diabetic groups significantly decreased Bax and Bax/Bcl2 ratio and significantly increased Bcl2 (P=0.018).
Conclusion: Our finding showed that diabetes could increase apoptosis in cardiac tissue. In addition, the six-week aerobic exercise can be used as a non-pharmacological strategy to reduce diabetes-related apoptosis in cardiomyocytes.

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