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Halakou A, Khormali M, Yamrali A, Zandi T M,
Volume 5, Issue 1 (spring-summer[PERSIAN] 2011)

Abstract Background and objectives: Helicobacter pylori is a Gram- negative bacteria causing diseases such as peptic ulcer and gastric cancer. In this research ,we determined the level of three types of antibody IgG, IgM and IgA in ordinary people of Izeh. Material and Methods: After collecting blood samples from 263 cases, the serum were obtaind and using the ELISA method the amount of IgG, IgM and IgA, against Helicobacter pylori measured. Results: Eleven samples(4.3%) out of 263 casese are positive for IgM anti-Helicobacter pylori. The frequency of IgA and IgG is 28(10.6%) and 201(76.4%),respectively. Conclusion: Based on results more than 70% of people in Izeh have Anti- Helicobacter pylori antibody in their serum, which is higher than that the other studied in Iran and also than developed countries. Key words: Seroepidemiology, Helicobacter pylori, Izeh
Mahshid Zandi , Mohammad Ebrahimifard, Abdolvahab Moradi,
Volume 11, Issue 3 (May-Jun 2017)

       Background and Objective: MiRNAs are small RNAs that are expressed in most eukaryotes, and can regulate gene expression by attaching to the 3’ end of target mRNA. MicroRNA-101 (miR-101) post-transcriptional regulation is important for host-virus interactions. In addition, miR-101 has a tumor suppressive role in liver cancer and metastasis, and induces apoptosis in tumor cells. We examined miR-101 expression in patients with chronic hepatitis B, hepatitis B virus (HBV)-associated cirrhosis and healthy individuals.
       Methods: The study was performed on 108 whole blood samples (36 samples from each group) collected in EDTA tubes. RNA was extraction by RNX-plus kit according to the manufacturer’s protocol. Finally, miRNA expression was evaluated using relative real time PCR.
         Results: A 2.4-fold increase was observed in miR-101 expression in patients with chronic hepatitis B, while there was a 3.5-fold increase in miR-101 expression in patients with HBV-associated cirrhosis compared with healthy controls (P=0.003). MiR-101 overexpression in patients with HBV-associated cirrhosis was more notable that in patients with chronic hepatitis B.
         Conclusion: According to the results, evaluating miR-101 expression may predict disease progression from chronic hepatitis B to HBV-associated cirrhosis.
         Keywords: MicroRNAs, Chronic Hepatitis B, Liver Cirrhosis, MiR-101.

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