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A Tabandeh, H Organji, M Aarabi,
Volume 7, Issue 1 (spring[PERSIAN] 2013)

Abstract Background and Objective: Pre-eclampsia is the most common cause of maternal and neonatal mortality. Recent studies show that there may be a relationship between chorionic gonadotropine (HCG) and pre-eclampsia. Thus we aimed at assessing the serum level of βhCG after 28th week of pregnancy in mild pre-eclamptic and healthy pregnant women. Material and Methods: In this case-control study, we measured the level of βhCG in 26 pre-eclamptic and 26 normal pregnant women. The difference between groups was analyzed by Mann-Whitney test (P≤ 0.05). Results: The mean of βhCG in the case (73192 ± 42956 IU/L) and control group (34038 ± 21272 IU/L) is different significantly (P= 0.001). Considering mother’s age, gestational age and parity, there is a significant difference between the two groups (P=0.001). Conclusion: The results of our study show that the higher level of βhCG, the greater the risk of pre-eclampsia. Key words: Pre eclampsia, βhCG, Parity
Mohammad Mohammad Mostakhdem Hashemi , Afsaneh Tabandeh , Hamidreza Tajari , Nasser Behnampour, Azadeh Aliarab, Hamid Reza Joshaghani,
Volume 10, Issue 4 (Jul-Aug 2016 2016)


        Background and Objectives: sperm motility mainly depends on aerobic glycolysis, and lactate dehydrogenase (LDH) is a key enzyme in the last step of this process. On the other hand, fructose is considered as the main energy source for sperm motility. Therefore, this study aimed to evaluate the LDH activity and fructose levels and their correlation with sperm motion parameters in normospermic and asthenozospermic males.

       Methods: In this case-control study, 96 normospermic and 96 asthenozospermic males were enrolled.  The semen samples were analyzed by computer assisted semen analysis to identify sperm motion parameters. Seminal plasma fructose levels were measured using Seliwanoffchr('39')s test. LDH activity in the samples was evaluated using commercially available kits. The obtained data were analyzed by SPSS software (version 16).

       Results: The levels of LDH activity and fructose concentration were not different between the two groups. There was no correlation found between LDH activity and fructose concentration or sperm motility parameters. However, LDH was significantly correlated with sperm concentration in both groups.

      Conclusion: Although LDH activity and fructose levels seem to be influenced by sperm motility, other factors such as sperm concentration and total sperm count can also affect their seminal plasma levels. Thus, when the sperm concentrations are equal in study groups, the level of these factors are expected to be equal.

         Keywords: Lactate Dehydrogenase, Fructose, Sperm Motility, CASA.

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