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Showing 6 results for Najm

Mehdi Najm, Mahdi Fakhar,
Volume 9, Issue 4 (sep,Oct 2015 2015)
Abstract

Abstract

        Heavy metals have raised one of the most important problems in ecology and organisms life especially human being and animals. A variety of indicators including tissues of fish, birds and sediment have been used recently to measure the aquatic pollution with heavy metals. The aim of this study was to search the published articles in Iran and the world on the role of helminthic parasites as a bioindicator (biological indicators) in assessing the concentration of heavy metals. This study was a non-systematic review and data were collected from available databases such as, Google Scholar, Pubmed, Web of Science, Scopus and Scientific Information Database (SID).Most studies showed that helminthic parasites(particularly acanthocephalan and cestoda) could be used as bioindicators in assessing the concentration of heavy metals. However, limited investigations were conducted on nematoda and trematoda parasites and limited information was available regarding heavy metal bioindicatorsin Iran.

             Keywords: Parasitology, Acanthocephala, Bioindicator, Heavy Metals


Najmatol Sabah Alavizadeh, Amir Rashidlamir, Seyed Mahmood Hejazi ,
Volume 12, Issue 5 (Sep-Oct 2018)
Abstract

ABSTRACT
           Background and objectives:  Sirtuin-1 (SIRT1) is a conserved a NAD+-dependent protein deacetylase essential for cellular metabolism and defence against oxidative stress and endothelial dysfunction. This study aimed to compare effects of 8 weeks of aerobic and combined training on serum level of SIRT1 and PGC1-α in coronary artery bypass graft patients.
           Methods: In this semi-experimental study, 45 non-active men (mean age 47.4 ± 3.3 years) who had undergone coronary artery bypass graft surgery were randomly divided into three groups: aerobic training, combined resistance and aerobic training and control. Trainings were performed at 80% of maximum heart rate, three sessions a week for 8 weeks. Blood samples were collected 24 hours before the first exercise session and 48 hours after the last training session. T-test and one-way analysis of variance were used for assessment of within-group and between-group differences, respectively. P-values less than 0.05 were considered as statistically significant.
           Results: The 8-week aerobic and combined training increased serum levels of SIRT1 and PGC-1α compared with the control group, and significantly decreased the weight of subjects (p=0.001). There was no significant difference in serum levels of SIRT1 and PGC-1α between the two training groups (P≥0.05).
           Conclusion: Both combined and aerobic training significantly improve the SIRT1 and PGC-1α levels in coronary artery bypass graft patients.
           KEYWORDS: Combined training, Aerobic training, PGC-1α, SIRT1, CABG patient.

Najmeh Alsabah Alavizadeh , Amir Rashidlamir , Seyed Mahmud Hejazi ,
Volume 13, Issue 2 (Mar-Apr 2019)
Abstract

ABSTRACT
             Background and Objectives: Cardiac rehabilitation improves functional capacity of post-coronary artery bypass grafting (CABG) patients. Therefore, the aim of this study was to evaluate effects of eight weeks of cardiac rehabilitation on serum levels of sirutin1 (SIRT1) and functional capacity of post-CABG patients.
             Methods: Forty-five non-active men (mean age: 47.4 ± 3.3 years, duration of disease: 150 ± 69.12 months) were randomly divided into three equal groups: aerobic exercise, combined (resistance and aerobic) exercise and control. The subjects performed trainings at 60-75% of maximum heart rate, three sessions a week for eight weeks. Blood samples were collected 24 hours before the first exercise session and 48 hours after the last exercise session. Data were analyzed with SPSS 16.0 using one-way ANOVA and the Tukey post hoc test. P-values less than 0.05 were considered statistically significant.
             Results: Aerobic and combined exercise increased serum SIRT1 levels and functional capacity. There was no significant decrease in body mass index (P=0.06). The SIRT1 level did not differ significantly between the two exercise groups after the intervention (P=0.91). There were significant difference between the study groups in terms of the travelled distance (P<0.034).
             Conclusion: Both combined and aerobic exercise can increase serum levels of SIRT1, reduce body mass index and improve functional capacity in CABG patients.
             Keywords: Resistance training, exercise, SIRT1.

Najmeh Jomehpour , Kiarash Ghazvini , Mahshid Jomehpour ,
Volume 13, Issue 3 (May-Jun 2019)
Abstract

ABSTRACT
            Background and Objectives: Medicinal and aromatic plants are sources of natural antimicrobial compounds that could be useful replacements for antibiotics. The aim of this study was to assess antimicrobial activity of Crocus sativus stigma and Cinnamomum cassia extracts against some Gram-positive and Gram-negative bacteria.
            Methods: Antimicrobial activity of methanolic and aqueous extracts of the plants was tested against clinical isolates of Klebsiella pneumonia, Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and Enterococcus using the microdilution method. Minimal inhibitory concentration (MIC) and minimum bactericidal concentration of each extract against the mentioned bacteria were also determined.
            Results: The MIC of the methanolic extract of C. cassia was 80 µg/ml against Enterococcus, K. pneumonia and E. coli. The MIC of the methanolic extract of C. sativus was 160 µg/ml against Enterococcus and S. aureus. The minimum bactericidal concentration of the methanolic extracts of C. sativus and C. cassia was 320 µg/ml against K. pneumonia and 160 µg/ml against Enterococcus.
            Conclusion: The extracts of C. sativus and C. cassia exhibit promising antibacterial activities against clinical isolates of the tested bacteria. Our results suggest that the extract of these plants can be further exploited as potential antibacterial agents against multi-drug resistant bacteria.
            Keywords: Cinnamomum aromaticum, Crocus, Anti-Bacterial Agents.

Najmatol Sabah Alavizadeh, Amir Rashidlamir, Seyed Mahmoud Hejazi,
Volume 15, Issue 1 (Jan-Feb 2021)
Abstract

Background and objectives: Chemokines are a group of proteins involved in both innate and adaptive immunity with a significant role on homeostasis and immune system development. The present study aimed to evaluate effects of eight weeks of cardiopulmonary rehabilitation exercise after coronary artery bypass surgery on expression of chemokines CCL2 and CCL5 in peripheral blood mononuclear cells of middle-aged men.
Methods: The study was performed on 45 middle-aged men that had undergone coronary artery bypass surgery. The subjects were randomly divided into three groups of control (n=15), aerobic exercise (n=15) and combined aerobic-resistance exercise (n=15). The trainings were performed three times a week for eight weeks at 60-75% of target heart rate. Fasting blood samples were collected 24 hours before the first training session and 48 hours after the last training session. Lymphocytes were separated by centrifugation. Change in gene expression was investigated by real time-PCR. Data were analyzed in SPSS (version 16) using one-way analysis of variance and Tukey’s post hoc test.
Results: The eight week exercise training significantly decreased expression of CCL2 compared to the control group.
Conclusion: Rehabilitation exercise can be an effective way to prevent, control or reduce atherosclerosis by lowering expression of CCL2 and CCL5.

Maryam Karimi, Mahtab Moazzami, Najmeh Rezaeian,
Volume 15, Issue 1 (Jan-Feb 2021)
Abstract

Background and objectives: Multiple sclerosis (MS) is a common debilitating neurodegenerative disease caused by inflammatory demyelinating processes in the central nervous system. The present study aimed to evaluate the effects of core stability training on serum levels of progranulin and tumor necrosis factor alpha (TNF-α) in women with MS.

Methods: The study population consisted of 24 women with MS (aged 25 to 40 years) in Bojnourd (Iran) with expanded disability status scale score of 2-5. Patients were randomly divided into two groups of core stability training (n=12) and control (n=12). The training group performed 30-40 minutes of core stability training, three sessions a week for eight weeks. Blood sampling was done 24 hours before the first session and 48 hours after the last training session. Serum levels of progranulin and TNF-α were measured using commercial ELISA kits. Analysis of covariance was used to assess data at a significance level of 0.05 . 
Results: The eight-week core stability training was associated with a significant increase in serum level of progranulin (P=0.037) and a significant decrease in the level of TNF-α (P=0.000).
Conclusion: The findings indicate that the eight-week core stability training could significantly change serum levels of progranulin and TNF-α and improve the condition of women with MS. Therefore, this type of training could be applied as a complementary therapy for MS patients.


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