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Showing 6 results for Mohades

Sh Shargh, M A Yeghaneh, Sm Mohades, A A Ayetollahi, A Khalaj, A Khandan Del,
Volume 4, Issue 1 (Spring - Summer 2010[PERSIAN] 2010)
Abstract

Spring summer 2010, Vol.4, No.1 /72 Medical Laboratory Journal Evaluation of Cholesterol Panel Changes in Fish Consumers in the West of Mazandaran Province, Iran Abstract Bachground and objectives: Eating fish reduces low-density lipoprotein cholesterol (LDL-C) and increases high density lipoprotein cholesterol (HDLC). Because of different factors, such as physiological conditions and kind of fish consumption, the findings can be different. We decided to investigate the reducing effect of regular fish eating on plasma lipids and lipoproteins of different groups. Material and Methods: the Subjects were 50 clients (control group) with normal Lipid and 50 ones with high Lipid (case group). The subjects, with different sex and age, were asked about smocking, heart disease and diabetes. Fast blood samples were collected and analyzed for total cholesterol (TC), low and high density lipoprotein cholesterol (LDL-C, HDL-C and VLDL), TG, HDLC, apolipoprotein A and B. Results: The data shows a significant difference in cholesterol, LDL, apoA and VLDL levels in moderate and high consumers. (P<0.005). In subjects with high LDL, the kind of fish consumption was stir- fried (0.96%) and grilled and boiled (7.4%). The Subjects with high-fish consumption is 32.2% for normal LDL Level and Just 1.1% for ab normal Level. There is no significant effect on HDL and apoB levels due to fish intake in any dosage. The relation is seen between abnormal lipid and rare fish consumption. Conclusion: Present study shows the reducing effect of fish consumption on cholesterol level and LDL-C. More studies are needed to be conducted to evaluate the type of faty acids in fishes. . Key words: Fish, dietary, cholesterol panel. Shargh SH FacultyMember of Dept of Laboratory Sciences, Islamic Azad University, Chaloos Branch Yeghaneh MA FacultyMember of Dept of Laboratory Sciences, Islamic Azad University, Chaloos Branch Mohades SM (PhD) Assistant Professor of Health Faculty, Tabriz University of Medical Sciences Ayetollahi AA (MD) FacultyMember of Dept of Lab Sciences, Paramedical Faculty, Golestan University of Medical Sciences Khalaj E (BSc) Daghigh Clinical Laboratory Khandan Del A Laboratory Technician, Islamic Azad university,Chaloos Braneh Corresponding: Shargh, SH Email:shohrehshargh@gmail.com
Maryam Moradibinabaj , Mohadese Namjoo , Mojgan Nejabat , Hamidreza Joshaghani ,
Volume 10, Issue 1 (Jan,Feb 2016 2016)
Abstract

ABSTRACT

       Background and Objective: The association of Triglyceride/High Density Lipoprotein-Cholesterol (TG/HDL-C) ratio with fasting serum insulin, which is an alternative method of insulin resistance (IR) measurement, is well-recognized. Thus, the measurement of TG/HDL-C ratio is useful to determine both IR and dyslipidemia, which itself is a characteristic of individuals with IR. Therefore, this study aimed to investigate the relationship between TG/HDL ratio as an indicator of IR, with different fasting blood glucose levels.

      Methods: This case-control study was performed on 343 volunteers with no history of diabetes or use of blood glucose-lowering medications and fasting blood sugar (FBS) levels of less than 126 mg/dl. After sampling, the subjects were divided into three groups based on their FBS level. First group included healthy subjects with FBS of less than 100 mg/dl. Second group consisted of subjects with impaired fasting glucose (IFG) and FBS of 110-100 mg/dl and a third group including those with impaired glucose tolerance (IGT) and FBS of 110-125 mg/dl.

       Results: The amount of TG/HDL-C ratio was 3.8 ± 2.8, 4.0 ± 2.1 and 5.4 ± 3.8 for the healthy group, individuals with IFG and IGT, respectively. The TG/HDL index was significantly different among the tested groups with no significant difference between healthy subjects and subjects with IFG. Moreover, there was a statistically significant difference between the IGT and IFG groups with healthy individuals.

       Conclusion: Considering the significant increase of the TG/HDL ratio in groups with impaired glucose, using this index can be helpful in evaluation of glycemic disorder.

  


Mohadese Namjoo, Seyed Ali Taheri, Maryam Moradi, Mojgan Nejabat, Zahra Gari, Maryam Saboktakinrizi,
Volume 11, Issue 1 (Jan-Feb- 2017 2017)
Abstract

ABSTRACT
        Background and Objectives: The unfavorable lipid profile in obese individuals is associated with high incidence of various diseases including cardiovascular disease, hypertension, etc. Dieting for weight loss and physical activity are among the most important factors affecting the serum lipid profile. The aim of this study was to compare the effect of diet with and without physical activity on body mass index and serum lipid profile of obese women.
      Methods: This clinical trial was performed in 2011 on 39 obese women referred to a weight loss and nutrition counseling center. Subjects were randomly divided into an active group (diet and exercise) and inactive group (diet without exercise). Blood sampling was done before the intervention and two months after the intervention. Data was analyzed using SPSS-16 and t-test.
       Results: Mean level of triglyceride reduced significantly in both groups. Mean level of cholesterol and low-density lipoprotein decreased significantly only in the active group. The Mean level of high-density lipoprotein in the two groups had no significant difference.
Conclusion: The results indicate that dieting for weight loss along with short-term physical activity improves serum levels of cholesterol and low-density lipoprotein, but does not affect serum HDL level.
        Keywords: Diet, Exercise, Triglyceride, Cholesterol, LDL, HDL.

Majid Komijani, Khashayar Shahin, Mohadeseh Barazandeh, Mehdi Sajadi,
Volume 12, Issue 5 (Sep-Oct 2018)
Abstract

ABSTRACT
            Background and Objectives: Pseudomonas aeruginosa is an opportunistic pathogen resistant to various antibiotics. The aim of the present study was to study resistant patterns in clinical isolates of P. aeruginosa, classify them into pandrug resistance (PDR), extensive drug resistance (XDR) and multidrug resistance (MDR) groups, and identify extended-spectrum β-lactamase (ESBL)-positive isolates using the phenotypic and genotypic methods.
            Methods: This cross-sectional study was conducted on 161 P. aeruginosa isolates collected from the city of Isfahan, Iran. Antibiotic susceptibility tests were performed using 11 antimicrobial agents. ESBL-positive strains were identified using the phenotypic and genotypic methods.
            Results: The highest level of antibiotic resistance was observed against ceftazidime (77.64%). None of the isolates was resistant to polymyxin B. In the phenotypic method, 64 isolates (39.75%) were found as ESLB-positive, whereas 132 isolates (81.98%) were ESBL-positive in the genotypic method. The number of ESBL-positive isolates in the genotypic method was significantly higher than in the phenotypic method. The frequency of XDR and MDR isolates was 50.93% and 27.32%, respectively. None of the isolates was PDR. The frequency of the blaTEM gene was significantly higher than other genes (P<0.0001).
            Conclusion: It was revealed that the genotypic method was much more accurate in identifying ESBL-positive strains than the phenotypic method. Therefore, use of the molecular method may increase the chance of successful treatment with antibiotics of the β-lactam family.
            Keywords: Drug Resistance,  β-lactamases, Pseudomonas aeruginosa.

Mohadeseh Kamali, Ali Kamali, Mehdi Taheri Sarvtin,
Volume 14, Issue 3 (May-Jun 2020)
Abstract

Background and objective: Human breast milk is the primary food for newborns that possess all essential nutrients for their growth and health. However, breast milk can be contaminated with various toxins including aflatoxin M1 (AFM1), a hydroxylated metabolite of aflatoxin B1 formed in the liver and excreted into the breast milk. This toxin can have immunosuppressive, mutagenic, teratogenic and carcinogenic effects. The present study aimed to investigate the level of AFM1 in human breast milk samples from Jiroft (Kerman Province), Iran.
     Methods: A total of 84 human breast milk samples were collected from lactating mothers who were referred to number one clinic in Jiroft from April 2016 to January 2017. The level of AFM1 was measured using commercial enzyme-linked immunosorbent assay kits.
      Results: Aflatoxin M1 was detected in all (100%) human breast milk samples within the interval values of 3.2 to 8.8 ng/L (mean, 4.1±0.7 ng/L). The level of AFM1 in all samples was lower than the maximum tolerable limit (25 ng/L) suggested by the EU and the Codex Alimentarius Commission.
      Conclusion: Although AFM1 is present in all human breast milk samples from the city of Jiroft, the level of this toxin is within the tolerable limit. Therefore, it seems that infants are not at risk.

Mohadese Namjoo, Hossein Ghafoori, S. Mohsen Asghari,
Volume 17, Issue 1 (Jan-Feb 2023)
Abstract

Background and objectives: Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) inhibition results in an increase in apoptosis. It has been demonstrated that NF-κB subunit p65 phosphorylation at the IκB kinase phosphorylation site serine 536 (Ser536) is essential for the NF-κB nuclear translocation and activation. Therefore, NF-κB can be downregulated by suppressing its phosphorylation. The vascular endothelial growth factor receptor-2 (VEGFR-2) suppression could result in apoptosis induction. Therefore, targeting these pathways via VEGFR-2 inhibitors might have therapeutic potential for cancer treatment. It has been indicated that an antagonist peptide of VEGF, referred to as VGB3, could neutralize and recognize VEGFR2 in the tumoral and endothelial cells. This study aimed to induce apoptosis in human umbilical vein endothelial cells (HUVEC) cells through the inhibition of these signaling pathways.
Methods: Effects of different concentrations of VGB3 (1-200 ng/ml) were evaluated on the viability of HUVEC  cells using MTT assay. In addition, downstream signaling pathways in HUVE cells were evaluated through quantitative assessment of protein expression via western blotting.
Results: The results demonstrated that VGB3 treatment inhibited the growth of HUVEC cells. Moreover, Bcl-2 was decreased in the cells treated with the VGB3 compared to the control. Furthermore, VGB3 significantly enhanced the cleaved-caspase7 levels, which is an indicator of apoptosis progression. Altogether, VGB3 enhanced apoptosis in HUVEC cells.
Conclusion: Our results indicate that the peptide might be a potential candidate for antitumor therapy via inhibiting the NF-κB pathway.
 

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