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Showing 4 results for Hedayat Mofidi

M Hedayat Mofidi, A Moradi, M Saeedi, N Behnampoor, J Arab Yaramohammadi,
Volume 2, Issue 1 (Spring - Summer 2008[PERSIAN] 2008)

Abstract Backgrounds and objectives: Herpes simplex virus type 1 (HSV- 1) infections are mostly shown as a Herpes disease, but It causes conjunctivitis, genital herpes, encephalitis and newborn herpes. This study was conducted to determine the sero-epidemiologic prevalence of herpes simplex virus type 1 in cases referred to clinical laboratories of Gorgan, Iran. Material and methods: In this cross sectional study, we did random blood sampling on 406 cases referred to the Gorgan citychr('39')s clinical laboratories. These samples were analyzed for HSV-1 Immunoglobulin G and M antibodies using type- specific enzymelinked Immunoassays (ELISA). Results: Of 406 participants, the HSV-1 seroprevalence is 49% (44.3% and 4.7% for IgG and IgM respectively). There is not significant relationship between seropositive HSV-1 and gender, ethnicity, age and marital status. Conclusion: Sero-epidemiological of HSV-1 in Gorgan is the same of the other places in Iran, but it is higher than European and lower than African countries. It seems that the people’s culture is very important. Therefore it needs to be investigated more. Keywords: HSV-1, Antibody, Gorgan.
M Saeedi, S Bakhshandeh Nosrat, A Moradi, Sm Hedayat Mofidi, N Behnampoor,
Volume 3, Issue 1 (Spring - Summer 2009[PERSIAN] 2009)

Abstract Background and objectives: Infection has a Leading role in pregnancy. Cytomegalovirus (CMV), listeria and Toxoplasma are the most common causes of infection in human. Based on the previous researches, about 15-25 percent of being infected during pregnancy leads to some complications such as abortion, fetal death, early labor and etc. This study was designed to determine the seroprevalence of Cytomegalovirus (CMV), Toxoplasma gondii and Listeria moncytogenes among pregnant women in Gorgan, north of Iran (2005-2006). Material and Methods: we conducted this Simple randomized study on 118 unsuccessful pregnant woman and 99 successful ones referred to Deziani hospital in Gorgan. We assayed both IgG and IgM antibodies for CMV and Toxo by Elisa and IFA method for Listeria. In addition, we fill out a Check list and then use SPSS soft ware, chi square to analyze the data. Results: The frequency of IgG for CMV and Toxo is 89.9% and 45.5% in successful pregnant women and 77.1% and 44.1% for unsuccessful pregnant women (P=0.41, P=0.01). IgM frequency for CMV and Toxo is 14.1% and 46.5% in successful women and 30.5 and 21.7% in unsuccessful ones. (P=0.003, P=0.002)Total frequency (IgG, IgM) for Listeria is 7.62% and %3.03 in successful and unsuccessful women, respectively. There is a significant relation between abortion and IgM titer against Toxoplasma in successful and unsuccessful groups. (P=0.003).This relation is true for total antibody titer against Listeria (P=0.003). Conclusion: Because of high titer of antibodies against CMV, Toxo and Listeria in unsuccessful pregnant women, suffering from these agents during pregnancy may result in abortion and fetal death. Hence, we recommend to hold some preventive and educational program and also to assay antibodies against theses agents. Key words: Listeria moncytogenes, Cytomegalovirus (CMV), Toxoplasma gondii, success and non-success pregnancy, Serology, Gorgan
S M Hedayat Mofidi, F Kouhsar, H S Hedayat Mofidi,
Volume 4, Issue 1 (Spring - Summer 2010[PERSIAN] 2010)

Abstract Background and objectives: Recurrent Abdominal Pain (RAP) syndrome is a common disorder, especially in children with beta thalassemia major. These patients are predisposed to heart diseases which are caused by hemochromatosis (Iron overload), resulting in sudden death. Because of the role of Helico bacter pylori in causing abdominal pain and peptic ulcer, and in increasing the risk or exacerbating of heart diseases, it can be important in beta thalassemia major. This study aimed at determining the frequency of anti- H.pylori class IgA in patients suffered from beta thalassemia major. Material and Methods: In this descriptive-analytic Study, 132 beta thalassemia major Patients and 135 healthy cases were matched by age, sex and ethnic as a control group. The sera were separated from clot in first Seroepidemiology and along with the filled questionnaires sent to Immunology-hematology Laboratory of paramedical school, in which the samples were tested by ELISA method with Diagnostic kit for anti-H.pylori IgA and IgG classes detection. We analyzed the Data by chi square and Independent T and Fisher tests. Results: the results show that the difference between the anti-H.pylori class IgA in case (22.7%) and control group (17.8%) is not significant (P=0.6), But it is significant between anti-H.pylori IgG class, 81.8% for cases and 54.8% for controls (P<0.001). Conclusion: Based on the results, the rate of anti-H.P IgA class in case is 1.131 times more than control group, which is not significant. On the other hand , the rate of anti-H.P IgG is 1.478 times more than control group which is significant. Key words: Thalassemia, Helicobacter pylori, Gorgan, Sero epidemiology.
Azadi F, Hedayat Mofidi, M , Ali Arab, A , Hedayat Mofidi, H , Khorasaninjad, R , Ghasemi-Kebria, F , Roshandel, Gh ,
Volume 9, Issue 3 (Jul,Aug2015[PERSIAN] 2015)


Background and Objective: Helicobacterpylori(HP) is the most common bacterial infection in the world and it may be associated with chronic gastritis, pepticulcer disease, and gastricadenocarcinoma. The aim of this study was to determine the prevalence of HP in student of Golestan University of Medical Sciences (GOUMS).

Material and Methods: This cross-sectional study was conducted on students ofGOUMS in 2012. Anti-HP IaG and IgA were assessed byELISA method.

Results: The participants recruited  were 287 in that 101 (35.2%) were male and the rest female. Of 287 , 239 (83.3%) were positive for HP. The proportion of  men was 91.1% and women 79% (P =0.03). There was no significant relationship between HP infection and variables such as  age, blood group , place of residence, nativity, and level of education.

Conclusion: The prevalence of H. pylori infection in the students of  Golestan University of Medical Sciences is high.

Keywords: Helicobacter Pylori, Antibodies, Students, Golestan

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