Abstract

Background and Objective: Septi scrub is a new product based on chlorhexidine 4%, which  is produced for  surgical scrub in Iran. This study aimed to compare the disinfecting effect of Povidone Iodine and Septiscrub in surgical scrub.

Material and Methods: this crossover experimental study, one-week interval, was conducted to compare Povidone Iodine and Septiscrub. Three samples for  microbial cultures were obtained  from each  participant before, shortly and 40 minutes after scrubbing.

Results: The findings showed that the effect of Povidone iodine and Septiscrub solutions was significant on microbial growth of measure (P< 0.05). In both solutions, there was a significant difference in the rate of microbial growth between before  and  after scrub stages (P< 0.05). But between immediately after scrub and 40 minutes after  was not significant (P< 0.05).

Conclusion: given the equal effect of two solutions and lesser side effect of Septiscub , it is recommended that Septiscrub  be used instead of  Povidone iodine 7.5%.

Keywords: Surgical Scrub; Povidone Iodine; Septi Scrub.

Abstract

Background and Objective: Ophthalmic pterygium is a potentially vision-threatening lesion of unknown etiology that often extends on the corneal surface and has a worldwide distribution. Despite various studies, the pathogenesis of pterygium remains unclear and the involvement of human papillomavirus is controversial. We aimed to investigate the involvement of papillomavirus in pterygium formation.

Material and Methods: This case-control study was conducted on 50 tissue specimens of pterygium from the patients who had pterygium surgery as the case group and 10 conjunctival biopsy specimens of individuals without pterygium including the patients with  cataract surgery, as controls. The evidence of papillomavirus infection was tested by polymerase chain reaction (PCR).

Results: All samples, case and control, were not positive for papillomavirus. Both groups were positive for beta-globulin gene used to check the quality of extracted DNA.

Conclusion: In this study, due to the absence of papillomavirus in the context of Pterygium it seems that other factors are involved in causing the disease.

Keywords: Pterygium; Human Papilloma Virus; PCR.