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Showing 7 results for Azarbayjani

Masoud Zamani, Maghsoud Peeri, Mohammad-Ali Azarbayjani , Hasan Matinhomaee ,
Volume 10, Issue 4 (Jul-Aug 2016 2016)
Abstract

ABSTRACT

          Background and Objective: Adipose tissue secrets various hormones including adiponectin, which is closely related to weight control and energy, balance. This study investigated the effects of resistance training on adiponectin, testosterone and cortisol levels in untrained men.  

           Methods: Forty untrained men (mean age of 23.8±2.66 years, mean weight of 67.43 ± 4.96 kg) were randomly and equally assigned into groups of upper extremity resistance training, lower extremity resistance training, combined resistance training, and control. The subjects performed eight weeks of weight training, three sessions per week (five sets of 60-85% one repetition maximum). Blood sampling was done prior to the start of the program, after the fourth week, and after the eight week. Alpha level was set to 0.05 for all statically analyses.

         Results: Repeated measures ANOVA showed that eight weeks of upper extremities training significantly decreased body fat percentage (p=0.002, 7.39%), and significantly increased adiponectin (p=0.000; 90.42%) and testosterone (p=0.002; 24.19%) levels. In the lower extremities training group, body fat percentage (p=0.006, 7.39%) decreased significantly, while adiponectin (p=0.012; 87.82%) and testosterone (p=0.000; 23.54%) levels increased significantly compared to the pretest. Eight weeks of combined training significantly increased BMI (p=0.006, 1.88%), muscle mass (p=0.007, 2.24%), and adiponectin (p=0.000, 91.56%) level. However, cortisol level decreased (p=0.017, 19.17%) after four weeks of training.  

         Conclusion: Upper and lower extremities resistance trainings significantly change testosterone levels. Different types of resistance training significantly increases serum adiponectin level and changes body composition, which are effective in prevention of cardiovascular diseases.

         Keywords: Resistance Training, Adiponectin, Testosterone, Cortisol.


Seyed Javad Mirghani, Mohammad Ali Azarbayjani , Maghsoud Peeri,
Volume 12, Issue 6 (Nov - Dec 2018)
Abstract

ABSTRACT
Background and Objectives: Obesity is a global health problem that could lead to cardiovascular disease, diabetes and cancer. Polygenic obesity is caused by multiple factors, such as lack of exercise and excess food intake. In this study, we evaluated effects of 12 weeks of high-intensity interval training (HIIT) and isocratic moderate-intensity training (MIT) on anthropometric indices and insulin resistance in rats fed with a high-fat diet (HFD). 
Methods: Twenty-five male Wistar rats (mean age of 5-6 weeks) were divided into three groups: control group (HFD, N=5), HFD+ MIT (N=10) and HFD+ HIIT (N = 10). After placing the subjects on a HFD for 13 weeks, the exercise groups performed trainings for 12 weeks. 
Results: Body mass index and Lee index decreased significantly in both training groups (P≤0.05). There was no significant difference in insulin resistance between the three groups (P>0.05).
Conclusion: Based on the results, it can be concluded that HIIT is more effective than MIT in reducing some of the obesity markers in obese rats fed with a HFD. However, this type of training has no significant impact on insulin resistance.
Keywords: Obesity, High Intensity Interval Training, High-Fat Diet, Body composition Indexes.

Seyedeh Tahereh Haeri, Mohammad Ali Azarbayjani, Maghsoud Peeri,
Volume 13, Issue 4 (Jul-Aug 2019)
Abstract

Background and Objectives: Apoptosis is essential for the survival and normal functioning of multicellular organisms, yet any interruption in this process could be detrimental. Increased production of reactive oxygen species and oxidative stress are key factors affecting apoptosis. Our objective was to determine the impact of exercise with and without vitamin D supplementation on expression of FLIP, Fas, and caspase 8 in lung of rats poisoned with H2O2.
Methods: Forty-eight adult male rats were randomly divided into six groups: (C), (H), (HD), (HE), (HDE) and dimethyl sulfoxide. Groups H, HE, HD and HDE received 1 mmol/Kg intraperitoneal injection of H2O2. HE and HDE groups ran on treadmill for eight weeks. Expression of FLIP, Fas and caspase 8 was measured in lung tissues using RT-qPCR. Statistical analysis of data was carried out using SPSS 22 at significance level of 0.05.
Results: Vitamin D supplementation caused a significant decrease in expression of Fas (P=0.014) and caspase 8 (P=0.016) compared to the control group. However, it significantly overexpressed FLIP in the lung tissues compared to the control group (P=0.005). Exercise with and without vitamin D supplementation had no significant effect on the expression of the apoptosis regulatory genes.
Conclusion: Our results show that VD exerts protective effects on lung tissue by regulating apoptotic factors. Aerobic exercise alone and combined with VD has no significant effect on the apoptotic factors. These results indicate that VD supplementation can reduce lung injury under oxidative stress conditions.
 
Seyed Javad Mirghani, Mohammad Ali Azarbayjani, Maghsood Peeri, Abbasali Keshtkar,
Volume 13, Issue 6 (Nov-Dec 2019)
Abstract

ABSTRACT
           Background and Objectives: The purpose of this research was to determine effects of vitamin D supplementation during a course of endurance training on anthropometrical parameters of Wistar rats exposed to a high-fat diet.
Methods: In this experimental study, 38 Wistar rats aged 5-6 weeks were assigned to five groups: 1. Control with normal diet (n=5), 2. Control with high-fat diet (n=5), 3. High-fat diet and vitamin D supplementation (n=10), 4. High-fat diet and endurance training (n=10), and 5. High-fat diet, endurance training and vitamin D supplementation (n=10). The animals were subjected to a high-fat diet (40%) for 13 weeks, followed by 12 weeks of exercise and vitamin D supplementation.
Results: Weight (P=0.02), BMI (P=0.001), Lee index (P=0.01) and energy efficiency (P=0.001) differed significantly between groups 1 and 2. Feed efficiency (P=0.03) and energy efficiency (P=0.01) of groups 2, 3 and 4 were significantly different from that of the control group.
Conclusion: The results of the present study indicate that endurance training and vitamin D supplementation could significantly decrease some anthropometric indices.
Keywords: Endurance Training, Vitamin D, High Fat Diet, Anthropometric Indices.

Kazem Ranjbar, Hassan Matin Homaie, Mohammad Ali Azarbayjani, Maghsoud Piri,
Volume 14, Issue 1 (Jan-Feb 2020)
Abstract

Abstract
           Background and Objectives: Liver is one of the vital organs of the human body. Antioxidants have been shown to play important roles in reducing liver injuries. The aim of this study was to examine the effects of gallic acid supplementation and resistance exercise on liver damage biomarkers in male rats intoxicated by steroid anabolic.
           Materials and Methods: Forty-two male Wistar rats were randomly divided into six equal groups: control, sham, steroid anabolic (5 mg/kg), steroid anabolic (5 mg/kg) + gallic acid supplementation (50 mg/kg), steroid anabolic (5 mg/kg) + resistance exercise, and steroid anabolic (5 mg/kg) + gallic acid supplementation (50 mg/kg) + resistance exercise. Except for control and sham groups, all groups received (injection) steroid anabolic at a dose of 5 mg / kg body weight once a week. The resistance exercise protocol was comprised of three weekly exercise sessions by 5 rep/3 set of climbing ladder for eight weeks. Data were analyzed via ANOVA and Tukeychr('39')s post hoc test at a significance level of P<0.05.
           Results:  The hepatic enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase) and bilirubin (total and direct), "In the gallic acid supplementation group (P<0.01, p<0.01, p<0.01, p<0.02, and p<0.05, respectively), resistance training group (p<0.02, p<0.01, p<0.01, p<0.01, and p<0.05, respectively), and the gallic acid supplementation group with resistance exercise (P<0.02, p<0.01, p<0.01, p<0.01, and p<0.01, respectively)"  were significantly reduced compared to the anabolic steroid group.
           Conclusions: Gallic acid supplementation and resistance exercise significantly reduce liver damage biomarkers. However, the simultaneous use of resistance exercise and gallic acid supplementation has no increasing effects on these biomarkers.
           Keywords: Anabolic Agents, gallic acid, Resistance Training.

Seyedeh Tahereh Haeri, Mohammad Ali Azarbayjani, Maghsoud Peeri,
Volume 14, Issue 4 (Jul-Aug 2020)
Abstract

Background and Objectives: Prolonged exercise can reduce physiological capacities and cause DNA damage by inducing oxidative stress and inflammatory responses. Aerobic exercise reduces the risk of cancer by activating DNA repair enzymes and reducing oxidative stress. The aim of the present study was to investigate effects of eight weeks of aerobic exercise with and without vitamin D supplementation on DNA damage.
    
   Methods: Forty-eight adult male rats were randomly divided into six groups: control (C), H2O2 (H), H2O2 and vitamin D (HD), H2O2 and exercise (HE), H2O2,, vitamin D and exercise (HDE), and dimethyl sulfoxide. Cancer was stimulated through intraperitoneal injection of H2O2 (2 mmol/kg). Animals in groups HE and HDE ran on treadmill for eight weeks. Concentration of 8-hydroxy-2chr('39')-deoxyguanosine (8-OHdG) and O6-methylguanine DNA methyltransferase (MGMT) was measured by enzyme-linked immunosorbent assay. Statistical analysis of data was carried out using SPSS 22 at significance level of 0.05.
 
   Results: Vitamin D supplementation significantly lowered the level of 8-OHdG expression compared to the control group (P=0.0001). The 8-OHdG expression in the exercise group was slightly lower than control group (P=0.063). Combination of exercise and vitamin D supplementation had no significant effect on expression of 8-OHdG (P=0.281). Both exercise and vitamin D supplementation significantly increased MGMT expression compared to the control group (P=0.0001 and P=0.040). However, combination of exercise and vitamin D supplementation had no significant effect on MGMT expression (P=0.326).
 
  Conclusion: The results showed that aerobic exercise and vitamin D supplementation can have protective effects against DNA damage, possibly by increasing antioxidant capacity and DNA repair.

Aghil Sadighi, Ahmad Abdi, Mohammad Ali Azarbayjani, Alireza Barari,
Volume 15, Issue 1 (Jan-Feb 2021)
Abstract

Background and objectives: Cardiac apoptosis is one of the most important cardiovascular complications of diabetes. We aimed to investigate the changes of Bax, Bcl2 and caspase 3 in cardiac tissue of diabetic rats after six weeks aerobic exercise.
Methods: Thirty two male Wistar rats were randomly divided into healthy control, diabetes control and diabetes + exercise groups. Diabetes was induced by intraperitoneal injection of streptozotocin solution (55 mg/kg). Two weeks after the injection, fasting blood glucose levels were measured to confirm induction of diabetes. The exercise program was performed five days a week for six weeks. Variables were evaluated by ELISA and western blot analysis. All statistical analyses were performed in SPSS (version 22) using ANOVA and at significance of 0.05.
Results: The induction of diabetes in the control groups resulted in a significant increase in Bax, Bax/Bcl2 ratio and a significant decrease in Bcl2 levels (P=0.024). The six-week training exercise in diabetic groups significantly decreased Bax and Bax/Bcl2 ratio and significantly increased Bcl2 (P=0.018).
Conclusion: Our finding showed that diabetes could increase apoptosis in cardiac tissue. In addition, the six-week aerobic exercise can be used as a non-pharmacological strategy to reduce diabetes-related apoptosis in cardiomyocytes.


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