Showing 4 results for Abdi
J Panahi, Mr Havasian, J Abdi, K Sayehmiri,
Volume 8, Issue 5 (winter[PERSIAN] 2015)
Abstract
Abstract In this study, the prevalence of Echinococcus granulosus was surveyed by meta-analysis and systematic review. Using main keywords of Echinococcus granulosus, dog and carnivores, we searched standard sites such as Google scholar, SID, Pubmed, Iranmedex, Irandoc, Science direct and magiran. Fifteen reliable articles were reviewed and analyzed by STATA software, Ver 11. From obtained articles, the number of 2271 dogs, 167 jackals and 174 foxes have been investigated by Iranian researchers. The infection rate of E.granulosus was reported 27.4% (95% CI, 20.9-33.9) in this study in that the highest from north and north west of Iran with prevalence of 33.3 %(CI:22.1-44.4), the lowest by 21.9 %(CI:12.5-31.3) from west and south west of Iran and the average from the central region of Iran ( 26.9% CI:12.8-41). Among cities the highest (64%) and the lowest (3.3%) infection rate were reported in Garmsar city (2010) and Sistan and Balochestan province (1997). Given that the overall prevalence of E.granulosus in Iran is high, Control and prevention measures including destruction of stray dogs and treatment of owner dogs seems to be necessary. Keywords: Echinococcus Granulosus, Carnivores, Iran, Systematic Review
Alireza Barari, Faeghe Dehghani Pour, Ahmad Abdi, Parvin Farzanegi,
Volume 14, Issue 2 (Mar-Apr 2020)
Abstract
ABSTRACT
Background and objectives: Nonalcoholic fatty liver disease (NAFLD) is a chronic hepatic disease characterized by fat accumulation inside hepatocytes. The aim of this study was to evaluate effects of exercise training and resveratrol supplementation on activin A and follistatin levels in rats with NAFLD under a high-fat diet.
Methods: Fifty-six old (40-50 weeks) male Wistar rats were assigned to a healthy control group and seven experimental NAFLD groups: 1. high-fat diet, 2. saline, 3. resveratrol supplementation, 4. continuous exercise, 5. interval exercise, 6. continuous exercise+ resveratrol supplementation and 7. interval exercise+ resveratrol supplementation. Rats in the resveratrol supplementation groups were given 25 mg/kg of body weight intraperitoneal injection of resveratrol daily. Exercises were performed five days a week for eight weeks. Data were analyzed with SPSS (version 21) using one-way analysis of variance (ANOVA) and Tukey's post hoc test at significance of 0.05.
Results: Exercise training and resveratrol supplementation significantly decreased plasma activin A level and increased activin A expression (P<0.05). Plasma level of follistatin was significantly higher in rats under a high-fat diet compared to healthy control animals. All exercise and supplementation groups alone and combined lowered follistatin levels. However, follistatin mRNA expression increased significantly after resveratrol supplementation alone, continuous exercise+ resveratrol supplementation, and interval exercise+ resveratrol supplementation.
Conclusion: Resveratrol has a beneficial effect on activin A and follistatin levels in rats with NAFLD. In addition, resveratrol supplementation combined with exercise training may have greater health benefits for NAFLD patients compared to resveratrol supplementation or exercise training alone.
Keywords: Exercise,
Resveratrol,
Activin A,
Follistatin, Nonalcoholic Fatty Liver Disease.
Aghil Sadighi, Ahmad Abdi, Mohammad Ali Azarbayjani, Alireza Barari,
Volume 15, Issue 1 (Jan-Feb 2021)
Abstract
Background and objectives: Cardiac apoptosis is one of the most important cardiovascular complications of diabetes. We aimed to investigate the changes of Bax, Bcl2 and caspase 3 in cardiac tissue of diabetic rats after six weeks aerobic exercise.
Methods: Thirty two male Wistar rats were randomly divided into healthy control, diabetes control and diabetes + exercise groups. Diabetes was induced by intraperitoneal injection of streptozotocin solution (55 mg/kg). Two weeks after the injection, fasting blood glucose levels were measured to confirm induction of diabetes. The exercise program was performed five days a week for six weeks. Variables were evaluated by ELISA and western blot analysis. All statistical analyses were performed in SPSS (version 22) using ANOVA and at significance of 0.05.
Results: The induction of diabetes in the control groups resulted in a significant increase in Bax, Bax/Bcl2 ratio and a significant decrease in Bcl2 levels (P=0.024). The six-week training exercise in diabetic groups significantly decreased Bax and Bax/Bcl2 ratio and significantly increased Bcl2 (P=0.018).
Conclusion: Our finding showed that diabetes could increase apoptosis in cardiac tissue. In addition, the six-week aerobic exercise can be used as a non-pharmacological strategy to reduce diabetes-related apoptosis in cardiomyocytes.
Hadi Alinejad, Asieh Abbassi Daloii, Parvin Farzanegi, Ahmad Abdi,
Volume 15, Issue 1 (Jan-Feb 2021)
Abstract
Background and Objective: Osteoarthritis (OA) and cardiovascular disease (CVD) are highly prevalent. The purpose of the present study was to investigate the effect of regular aerobic training and hyaluronic acid on cardiac tissue Wnt signaling pathway in experimental model of knee OA.
Methods: 42 male rats were divided into 6 groups (7 in each group): 1) control, 2) patient, 3) salin, 4) HA, 5) exercise, and 6) exercise + HA. In the training groups, the OA model was first induced, followed by 5 days of running on the treadmill for 5 weeks. Hyaluronic acid was injected intra-articularly. After 12 to 14 hours of fasting and 72 hours after the last training session, cardiac tissue sampling was performed for β-catenin and glycogen synthase kinase-3 (GSK-3β) analysis. The expression of the β-catenin and GSK-3β genes in the cardiac tissue was analyzed by RT-PCR. Data analysis was performed using one-way ANOVA if a significant difference was observed by Tukey's post hoc test (P <0.05).
Results: Induction of OA in rats led to a significant increase in β-catenin gene and a significant decrease in cardiac tissue GSK3 gene compared to healthy control group. The results also showed that regular aerobic training, hyaluronic acid injection, and a combination of both treatments reduced the cateninβ gene and increased the cardiac tissue GSK3 gene compared to the rats of OA group.
Conclusion: Regular aerobic training in combination with hyaluronic acid may exert its protective effect by reducing the expression of β-catenin and increasing the expression of cardiac tissue GSK-3β gene ; this may be caused by the heart disease in the model, empirically preventing osteoarthritis.
