Volume 9, Issue 3 (Jul,Aug2015[PERSIAN] 2015)                   mljgoums 2015, 9(3): 135-140 | Back to browse issues page

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Kelishadi, M, Kelishadi, M. (MD), Moradi, A, Bazouri, M, Tabaraei, A. Molecular Epidemiology of Human Papillomavirus in Pterygium. mljgoums 2015; 9 (3) :135-140
URL: http://mlj.goums.ac.ir/article-1-755-en.html
1- Golestan University of Medical Sciences, Gorgan, Iran
2- School of Nedicine, Golestan University of Medical Sciences, Gorgan, Iran
3- School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
Abstract:   (12473 Views)

Abstract

Background and Objective: Ophthalmic pterygium is a potentially vision-threatening lesion of unknown etiology that often extends on the corneal surface and has a worldwide distribution. Despite various studies, the pathogenesis of pterygium remains unclear and the involvement of human papillomavirus is controversial. We aimed to investigate the involvement of papillomavirus in pterygium formation.

Material and Methods: This case-control study was conducted on 50 tissue specimens of pterygium from the patients who had pterygium surgery as the case group and 10 conjunctival biopsy specimens of individuals without pterygium including the patients with  cataract surgery, as controls. The evidence of papillomavirus infection was tested by polymerase chain reaction (PCR).

Results: All samples, case and control, were not positive for papillomavirus. Both groups were positive for beta-globulin gene used to check the quality of extracted DNA.

Conclusion: In this study, due to the absence of papillomavirus in the context of Pterygium it seems that other factors are involved in causing the disease.

Keywords: Pterygium; Human Papilloma Virus; PCR.

Research Article: Original Paper |
Received: 2015/10/13 | Accepted: 2015/10/13 | Published: 2015/10/13 | ePublished: 2015/10/13

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.