Volume 15, Issue 1 (Jan-Feb 2021)                   mljgoums 2021, 15(1): 19-25 | Back to browse issues page


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Alavizadeh N S, Rashidlamir A, Hejazi S M. Effect of Eight Weeks of Aerobic and Aerobic-Resistance Trainings after Coronary Artery Bypass Grafting on Expression of CCL2 and CCL5 in Middle-Aged Men. mljgoums 2021; 15 (1) :19-25
URL: http://mlj.goums.ac.ir/article-1-1296-en.html
1- Assistant Professor, Department of Sports Physiology, Zahedan branch, Islamic Azad University, Zahedan, Iran , alavizade80@yahoo.com
2- Department of Sports Physiology, Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
3- Department of Physical Education, Khayyam University, Mashhad, Iran
Abstract:   (2328 Views)
Background and objectives: Chemokines are a group of proteins involved in both innate and adaptive immunity with a significant role on homeostasis and immune system development. The present study aimed to evaluate effects of eight weeks of cardiopulmonary rehabilitation exercise after coronary artery bypass surgery on expression of chemokines CCL2 and CCL5 in peripheral blood mononuclear cells of middle-aged men.
Methods: The study was performed on 45 middle-aged men that had undergone coronary artery bypass surgery. The subjects were randomly divided into three groups of control (n=15), aerobic exercise (n=15) and combined aerobic-resistance exercise (n=15). The trainings were performed three times a week for eight weeks at 60-75% of target heart rate. Fasting blood samples were collected 24 hours before the first training session and 48 hours after the last training session. Lymphocytes were separated by centrifugation. Change in gene expression was investigated by real time-PCR. Data were analyzed in SPSS (version 16) using one-way analysis of variance and Tukey’s post hoc test.
Results: The eight week exercise training significantly decreased expression of CCL2 compared to the control group.
Conclusion: Rehabilitation exercise can be an effective way to prevent, control or reduce atherosclerosis by lowering expression of CCL2 and CCL5.
Full-Text [PDF 699 kb]   (738 Downloads)    
Research Article: Original Paper | Subject: Human Genetics
Received: 2020/05/18 | Accepted: 2020/07/30 | Published: 2021/01/1 | ePublished: 2021/01/1

References
1. Zakynthinos E, Pappa N. Inflammatory biomarkers in coronary artery disease. J Cardiol. 2009;53(3):317-33. [DOI:10.1016/j.jjcc.2008.12.007] [PubMed] [Google Scholar]
2. Tedgui A, Mallat Z. Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol Rev. 2006; 86: 515-81. [DOI:10.1152/physrev.00024.2005] [PubMed] [Google Scholar]
3. Ross R. Atherosclerosis--an inflammatory disease. N Engl J Med. 1999; 340(2): 115-26. [DOI:10.1056/NEJM199901143400207] [PubMed] [Google Scholar]
4. Biasucci LM, Vitelli A, Liuzzo G, Altamura S, Caligiuri G, Monaco C, et al. Elevated levels of interleukin-6 in unstable angina. Circulation. 1996;94(5):874-7. [DOI:10.1161/01.CIR.94.5.874] [PubMed] [Google Scholar]
5. Baggiolini M, Dewald B, Moser B. Human chemokines: An update. Annu Rev Immunol. 1997;15:675-705. [DOI:10.1146/annurev.immunol.15.1.675] [PubMed] [Google Scholar]
6. Gerard C, Rollins BJ. Chemokines and disease. Nat Immunol. 2001;2(2):108-15. [DOI:10.1038/84209]
7. Le Y, Zhou Y, Iribarren P, Ming-Wang J. Chemokines and chemokine receptors: Their manifold roles in homeostasis and disease. Cell Mol Immunol. 2004;1(2):95-104. [PubMed] [Google Scholar]
8. Panee J. Monocyte chemoattractant protein 1 (MCP-1) in obesity and diabetes. Cytokine Oct. 2012;60(1):1-12. [DOI:10.1016/j.cyto.2012.06.018] [PubMed] [Google Scholar]
9. Lin J, Kakkar V, Lu X. Impact of MCP-1 in atherosclerosis. Curr Pharm Des. 2014;20(28):4580-8. [DOI:10.2174/1381612820666140522115801] [PubMed] [Google Scholar]
10. Moogooei M, Hasanshahi G, Jafarzadeh A, Khoramdelazad H, Moogooei M, Fatahpour S. Distinct Pattern of CC Chemokine 2 and 5 in Post-Transurethral Resection of Bladder Cancer Journal of Ilam University of Medical Sciences. 2015;24(1):144-53.(persian) [View at Publisher] [DOI:10.18869/acadpub.sjimu.24.1.144] [Google Scholar]
11. Billebeau G, Vodovar N, Sadoune M, Launay JM, Beauvais F, Cohen-Solal A. Effects of acardiac rehabilitation programme on plasma cardiac biomarkers in patients with chronic heartfailure. European Journal of Preventive Cardiology. 2017;24(8):808-17. [DOI:10.1177/2047487317705488] [PubMed] [Google Scholar]
12. Passino C, Severino S, Poletti R, Piepoli MF, Mammini C, Clerico A, et al. Aerobic training decreases B-type natriuretic peptide expression and adrenergic activation in patients with heart failure. J Am Cardiol. 2006;47(9):1835-9. [DOI:10.1016/j.jacc.2005.12.050] [PubMed] [Google Scholar]
13. Gaeini A, Sattarifard S, CafiZadeh S, Nejatian M. The comparison of eight weeks of combined and aerobic training onfunctional capacity, body composition and strength in post-coronary artery bypass graft cardiac patients. Cardiovascular Nursing Journal. 2013;2(1):24-41.(persian) [View at Publisher]
14. Oliveira JL, Galvao CM, Rocha SM. Resistance exercises for health promotion in coronary patients: Evidence of benefits and risks. Int J Evid Based Healthc. 2008; 6(4): 431-9. [DOI:10.1097/01258363-200812000-00005]
15. Feyollah Zadeh Moosavi R, Rashidlamir A, Khajei R, Hejazi M. The effect of combined training on ABCG1 gene expression in mononuclear cells after coronary artery bypass surgery in middle aged men.J Neyshabur Univ Med Sci, autumn, 2019;7(3):49-62. [View at Publisher]
16. American College of Sports Medicine. ACSM's Guidelines for Exercise Testing and Prescription. 6, editor. Baltimore: Md: Lippincott Williams & Wilkins; 2000.
17. Adams BJ, Carr JG, Ozonoff A, Lauer MS, Balady GJ. Effect of exercise training in supervised cardiac rehabilitation programs on prognostic variables from The exercise tolerance test. AM j cardiol. 2008;101(10):1403-7. [DOI:10.1016/j.amjcard.2008.01.016] [PubMed] [Google Scholar]
18. Choo J, Burke LE, Pyo-Hong K. Improved quality of life with cardiac rehabilitation for post myocardial infarction patients in Korea. Eur J CardiovascNurs. 2007;6(3):166-71. [DOI:10.1016/J.EJCNURSE.2006.07.004] [PubMed] [Google Scholar]
19. Siavoshi S, Roshandel M, Zareiyan A, Ettefagh L. The effect of cardiac rehabilitation care plan on the quality of life in patients undergoing coronary artery bypass graft surgery. Cardiovascular Nursing Journal. 2012;1(2):38-46.(persian) [View at Publisher] [Google Scholar]
20. Pollock ML, Franklin BA, Balady GJ, Chaitman BL, Fleg JL, Fletcher B, et al. AHA Science Advisory. Resistance exercise in individuals with and without cardiovascular disease: benefits, rationale, safety, and prescription an advisory from the committee on exercise, rehabilitation, and prevention, council on clinical cardiology, AmericanHeart Association. Circulation2000;101(7):828-33. [DOI:10.1161/01.CIR.101.7.828] [PubMed] [Google Scholar]
21. Reisi J, Rajabi H, Ghaedi K, Marandi SM, Asadysamani Z, Kazeminasab F. Effect ofeight weeks' resistance training on plasma irisin protein level and muscle FNDC5 and adipose tissue UCP1 genes expression in male rats. Exercise phisiology. 2015;7(28):117-30. [DOI:10.5812/asjsm.35205] [Google Scholar]
22. Ghanbari-Niaki A, Ghanbari-Abarghooi S, Rahbarizadeh F, Zare-Kookandeh N, Gholizadeh M, Roudbari F, et al. Heart ABCA1 and PPAR- α Genes Expression Responses in Male rats: Effects of High Intensity Treadmill Running Training and Aqueous Extraction of Black Crataegus-Pentaegyna. Res Cardiovasc Med. 2013;1(5):153-9.(persian) [DOI:10.5812/cardiovascmed.13892] [PubMed] [Google Scholar]
23. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta DeltaC(T)) Method. Methods. 2001;25(4):402-8. [DOI:10.1006/meth.2001.1262] [PubMed] [Google Scholar]
24. Wilmore JH. Aerobic Exercise and Endurance, Improving Fitness for Health Benefits. The physician and sports medicine. 2003;31(5):356-9. [DOI:10.3810/psm.2003.05.367] [PubMed] [Google Scholar]
25. Trøseid M, Lappega˚rd KT, Claudi T, Damås JK, Mørkrid L, Brendberg R, et al. Exercise reduces plasma levels of the chemokinesMCP-1 and IL-8 in subjects with the metabolicsyndrome. European Heart Journal. 2004;25(4):349-55. [DOI:10.1016/j.ehj.2003.12.006] [PubMed] [Google Scholar]
26. Pan J, Gao C. Association between MCP-1 A2518G polymorphism and coronary artery disease risk: evidence from 21 case-control studies. Int J Clin Exp Med. 2016;9(7):14087-95. [Google Scholar]
27. Kazemi A. Effect of high intensity interval training on visceral and subcutaneous levels of MCP-1 and plasma insulin and glucose in male rats. Razi journal of Medical Sciences. 2017;23(152):29-37.(persian) [Google Scholar]
28. Shi G, He G, Cai G, Qi CP, Gao L, Shen D, et al. Association between MCP-1 gene polymorphism and acute coronary syndrome in a Hanethnic Chinese cohort. world J Emerg Med. 2013;4(1):38-44. [DOI:10.5847/wjem.j.issn.1920-8642.2013.01.007] [Google Scholar]
29. Van-Wijk DF, Van-Leuven SI, Sandhu MS, Tanck MW, Hutten BA, Wareham NJ, et al. Chemokine Ligand 2 Genetic Variants, serum MCP-1 Levels and the Risk of Coronary Artery Disease. ArteriosclerThrombVasc Biol July. 2010;30(7):1460-6. [DOI:10.1161/ATVBAHA.110.205526] [PubMed] [Google Scholar]
30. Baturcam E, Abubaker J, Tiss A, Abu-Farha M, Khadir A, Al-Ghimlas F, et al. Physical Exercise Reduces the Expression of RANTES and its CCR5 Receptor in the Adipose Tissue of Obese Humans. Mediatirs of inflammation. 2014;2014:1-13. [DOI:10.1155/2014/627150] [PubMed] [Google Scholar]
31. Versteylen MO, Manca M, Joosen A, Schmidt DE, Das M, Hofstra L, et al. CC chemokine ligands in patients presenting with stable chest pain: association with atherosclerosis and future cardiovascular events. Neth Heart J. 2016;24(12):722-9. [DOI:10.1007/s12471-016-0884-9] [PubMed] [Google Scholar]
32. Liu J, Jia YJ, Li XL, Xu RX, Zhu CG, Guo YL, et al. RANTES Gene G-403A Polymorphism and Coronary Artery Disease: A MetaAnalysis of Observational Studies. PLoS ONE. 2012;7(10). [DOI:10.1371/journal.pone.0047211] [PubMed] [Google Scholar]
33. Kraaijeveld AO , de Jager SCA, de Jager WJ, Prakken BJ, McColl SR, Haspels I, et al. CC chemokine Ligand-5 (ccl5/RANTES) and CC chemokine ligand-18() are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms. Circulation. 2007; 116(17):1931-1941. [DOI:10.1161/CIRCULATIONAHA.107.706986] [PubMed] [Google Scholar]
34. Rothenbacher D, Müller-Scholze S, Herder Ch, Koenig W, Kolb H. Differential expression of chemokines, risk of stable coronary heart disease, and correlation with established cardiovascular risk markers. Arteriosclerosis, Thrombosis,and Vascular Biology.2006;26(1):194-199. [DOI:10.1161/01.ATV.0000191633.52585.14] [PubMed] [Google Scholar]
35. Blake GI, Ridker PM. Novel clinical marker of vascular wall inflammation. Circulation res. 2001;89(9):763-71. [DOI:10.1161/hh2101.099270] [PubMed] [Google Scholar]
36. ElMissiri A, Taher MA. Effect of Phase 2 Cardiac Rehabilitation Program on High-SensitivityC-ReactiveProteinLevels in Post-Percutaneous Coronary Intervention Patients. J Cardiovasc Res. 2016;5(1):1-6. [Google Scholar]
37. Fernandes-Silva MM, Guimarães GV, Rigaud VO, Lofrano-Alves MS, Castro RE, de-Barros-Cruz LG, et al. Inflammatory biomarkers and effect of exercise on functional capacity in patientswith heart failure: Insights from a randomized clinical trial. European journal of preventivecardiology. 2017;24(8):808-17. [DOI:10.1177/2047487317690458] [Google Scholar]
38. Razaghi A, Sadeghi H, Johari Moghadam A, Azma K, Motamedi P. The effect of exercise-based cardiac rehabilitation in two ways aerobic and aerobic-resistance exercises on the biomechanical function of cardiac patients (MI, PCI, and CABG). Razi J Med Sci. 2020;26(12):138-148. [View at Publisher] [Google Scholar]

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.