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Moosavi R, Rashidlamir A, Khajeie R, Hejazi M. Comparison of Combined and Aerobic Training on ABCG1 Lymphocyte Gene Expression in Middle-Aged Men Undergoing Coronary Artery Bypass Grafting. mljgoums 2021; 15 (2) :28-34
URL: http://mlj.goums.ac.ir/article-1-1294-en.html
URL: http://mlj.goums.ac.ir/article-1-1294-en.html
1- Islamic Azad University, Neyshabur Branch, Neyshabur, Iran
2- Ferdowsi University of Mashhad
3- Islamic Azad University, Neyshabur Branch, Neyshabur, Iran , r.khajeie@gmail.com
2- Ferdowsi University of Mashhad
3- Islamic Azad University, Neyshabur Branch, Neyshabur, Iran , r.khajeie@gmail.com
Abstract: (1730 Views)
Background and objectives: Cardiovascular disease is one of the most important causes of mortality worldwide. The present study aimed to compare two different cardiac rehabilitation protocols on ATP-binding cassette sub-family G member 1 (ABCG1) lymphocyte expression and blood lipid profile in middle-aged men undergoing coronary artery bypass grafting.
Methods: Forty five middle-aged men who had previously undergone coronary artery bypass surgery were randomly divided into three groups of control (C; n=15), aerobic training (AT; n=15) and combined training (CT; n=15). Blood samples were taken before the first and after the last exercise sessions. After isolation of mononuclear cells using Ficoll and mRNA purification, gene expression changes were examined by real-time PCR. Data were analyzed using one-way ANOVA and Bonferroni post-hoc tests.
Results: Eight weeks of training intervention resulted in a significant increase in ABCG1 expression as well as a significant decrease in plasma levels of LDL, triglyceride and total cholesterol in both training groups. However, there was no significant difference between the AT and CT groups. In addition, high-density lipoprotein was significantly increased in the AT and CT groups.
Conclusion: Both AT and CT can increase plasma LDL and increase ABCG1 expression and HDL concentrations, indicating the positive effects of both interventions on the prevention of atherosclerosis.
Methods: Forty five middle-aged men who had previously undergone coronary artery bypass surgery were randomly divided into three groups of control (C; n=15), aerobic training (AT; n=15) and combined training (CT; n=15). Blood samples were taken before the first and after the last exercise sessions. After isolation of mononuclear cells using Ficoll and mRNA purification, gene expression changes were examined by real-time PCR. Data were analyzed using one-way ANOVA and Bonferroni post-hoc tests.
Results: Eight weeks of training intervention resulted in a significant increase in ABCG1 expression as well as a significant decrease in plasma levels of LDL, triglyceride and total cholesterol in both training groups. However, there was no significant difference between the AT and CT groups. In addition, high-density lipoprotein was significantly increased in the AT and CT groups.
Conclusion: Both AT and CT can increase plasma LDL and increase ABCG1 expression and HDL concentrations, indicating the positive effects of both interventions on the prevention of atherosclerosis.
Keywords: Coronary Artery Bypass [MeSH], Circuit-Based Exercise [MeSH], ABCG1 [MeSH], Exercise [MeSH]
Research Article: Original Paper |
Subject:
Sport Physiology
Received: 2020/05/5 | Accepted: 2020/07/5 | Published: 2021/02/28 | ePublished: 2021/02/28
Received: 2020/05/5 | Accepted: 2020/07/5 | Published: 2021/02/28 | ePublished: 2021/02/28
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