Volume 14, Issue 5 (Sep-Oct 2020)                   mljgoums 2020, 14(5): 30-34 | Back to browse issues page

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Aminian F, hejazi M, Birjandi S C. Low-Intensity Blood Flow Restriction Training Does Not Modulate Myostatin Concentration in Elderly Females. mljgoums. 2020; 14 (5) :30-34
URL: http://mlj.goums.ac.ir/article-1-1245-en.html
1- Department of Exercise Physiology, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.
2- Department of Physical Education, Khayyam University, Mashhad, Iran , sm.hejazi37@gmail.com
Abstract:   (832 Views)
Background and objectives: Evidence suggests that decrease in the serum concentration of myostatin (MSTN) may reduce age-related decrement in muscle mass, especially in older individuals. This study aimed at investigating the effects of 12 weeks of resistance training with and without blood flow restriction on MSTN and muscular strength (MS) of elderly women.
Methods: Thirty elderly women were randomly assigned into three groups of resistance training with blood flow restriction (n=10), resistance training without blood flow restriction (n=10) and control (n=10). The resistance training intervention was carried out three sessions a week for 12 weeks. Body composition, MS and serum concentrations MSTN were assessed at baseline and 48-36 hours after the last training session.
Results: There was a significant time × group difference in MS following 12 weeks of exercise intervention (P=0.001). However, there was no significant group and time × group difference in MSTN concentrations (P=0.2).
Conclusion: Low intensity BFRT does not decrease MSTN concentrations in elderly women. However, low intensity BFRT can increase MS values in these individuals.
Full-Text [PDF 508 kb]   (177 Downloads)    
Research Article: Original Paper | Subject: Sport Physiology
Received: 2019/08/27 | Accepted: 2019/10/21 | Published: 2020/08/24 | ePublished: 2020/08/24

1. Larsson L, Degens H, Li M, Salviati L, Lee Yi, Thompson W, et al. Sarcopenia: aging-related loss of muscle mass and function. Physiol Rev. 2019; 99(1): 427-511.doi: 10.1152/physrev.00061.2017. [DOI:10.1152/physrev.00061.2017]
2. Hunter GR, McCarthy JP, Bamman MM. Effects of resistance training on older adults. Sports Med. 2004; 34(5): 329-48.doi: 10.2165/00007256-200434050-00005. [DOI:10.2165/00007256-200434050-00005]
3. Bagheri R, Rashidlamir A, Motevalli MS, Elliott BT, Mehrabani J, Wong A. Effects of upper-body, lower-body, or combined resistance training on the ratio of follistatin and myostatin in middle-aged men. Eur J Appl Physiol. 2019; 119(9): 1921-1931. doi: 10.1007/s00421-019-04180-z. [DOI:10.1007/s00421-019-04180-z]
4. Hakkinen K, Pakarinen A, Kraemer WJ, Newton RU, Alen M. Basal concentrations and acute responses of serum hormones and strength development during heavy resistance training in middle-aged and elderly men and women. J Gerontol A Biol Sci Med Sci. 2000; 55(2): B95-105.doi: 10.1093/gerona/55.2.b95. [DOI:10.1093/gerona/55.2.B95]
5. Bagheri R, Rashidlamir A, Attarzadeh Hosseini SR. Effect of Resistance Training with Blood Flow Restriction onfollistatin to myostatin Ratio, Body Composition and Anaerobic Power of Trained-Volleyball Players. Mljgoums. 2018; 12(6): 28-33. DOI: 10.29252/mlj.12.6.28. [DOI:10.29252/mlj.12.6.28]
6. Laplante M, Sabatini DM. mTOR signaling at a glance. Journal of cell science. 2009; 122(20): 3589-94. doi: 10.1242/jcs.051011. [DOI:10.1242/jcs.051011]
7. Laurentino GC, Ugrinowitsch C, Roschel H, Aoki MS, Soares AG, Neves Jr M, et al. Strength training with blood flow restriction diminishes myostatin gene expression. Med Sci Sports Exerc. 2012; 44(3): 406-12.doi: 10.1249/MSS.0b013e318233b4bc. [DOI:10.1249/MSS.0b013e318233b4bc]
8. Mafi F, Biglari S, Ghardashi Afousi A, Gaeini AA. Improvement in Skeletal Muscle Strength and Plasma Levels of Follistatin and Myostatin Induced by an 8-Week Resistance Training and Epicatechin Supplementation in Sarcopenic Older Adults. J Aging Phys Act. 2019; 27(3): 384-391.doi: 10.1123/japa.2017-0389. [DOI:10.1123/japa.2017-0389]
9. Negaresh R, Ranjbar R, Baker JS, Habibi A, Mokhtarzade M, Gharibvand MM, et al. Skeletal muscle hypertrophy, insulin-like growth factor 1, myostatin and follistatin in healthy and sarcopenic elderly men: The effect of whole-body resistance training. Int J Prev Med. 2019;10:29.doi: 10.4103/ijpvm.IJPVM_310_17. eCollection 2019. [DOI:10.4103/ijpvm.IJPVM_310_17]
10. Jones CJ, Rikli RE, Beam WC. A 30-s chair-stand test as a measure of lower body strength in community-residing older adults. Res Q Exerc Sport. 1999 Jun;70(2):113-9.doi: 10.1080/02701367.1999.10608028. [DOI:10.1080/02701367.1999.10608028]
11. Vechin FC, Libardi CA, Conceição MS, Damas FR, Lixandrão ME, Berton RP, et al. Comparisons between low-intensity resistance training with blood flow restriction and high-intensity resistance training on quadriceps muscle mass and strength in elderly. Randomized Controlled Trial J Strength Cond Res. 2015; 29(4): 1071-6.doi: 10.1519/JSC.0000000000000703. [DOI:10.1519/JSC.0000000000000703]
12. Fujita T, WF B, Kurita K, Sato Y, Abe T. Increased muscle volume and strength following six days of low-intensity resistance training with restricted muscle blood flow. International Journal of KAATSU Training Research. 2008; 4(1): 1-8. DOI: 10.3806/ijktr.4.1. [DOI:10.3806/ijktr.4.1]
13. Lundberg G, Olofsson P, Ungerstedt U, Jansson E, Sundberg C. Lactate concentrations in human skeletal muscle biopsy, microdialysate and venous blood during dynamic exercise under blood flow restriction. Pflugers Arch. 2002; 443(3): 458-65.doi: 10.1007/s004240100706. [DOI:10.1007/s004240100706]
14. Meriin AB, Gabai VL, Yaglom J, Shifrin VI, Sherman MY. Proteasome inhibitors activate stress kinases and induce Hsp72 Diverse effects on apoptosis. Journal of Biological Chemistry. 1998; 273(11): 6373-9. [DOI:10.1074/jbc.273.11.6373]
15. Yarasheski K, Bhasin S, Sinha-Hikim I, Pak-Loduca J, Gonzalez-Cadavid N. Serum myostatin-immunoreactive protein is increased in 60-92 year old women and men with muscle wasting. J Nutr Health Aging. 2002; 6(5): 343-8.
16. Gilson H, Schakman O, Combaret L, Lause P, Grobet L, Attaix D, et al. Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy. Endocrinology. 2007; 148(1): 452-60.doi: 10.1210/en.2006-0539. [DOI:10.1210/en.2006-0539]

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