Volume 11, Issue 6 (Nov - Dec 2017)                   mljgoums 2017, 11(6): 1-6 | Back to browse issues page


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1- Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
2- Department of Biology, Faculty of Basic Sciences, Hakim Sabzevari University, Sabzevar, Iran
Abstract:   (14311 Views)
ABSTRACT
         Background and Objectives: The present study aimed to investigate effects of eight weeks of aquatic exercise and resistance training on plasma neurotrophin-4 (NT-4) levels and NT-4 expression in peripheral blood mononuclear cells (PBMCs) of women with multiple sclerosis (MS).
         Methods: Thirty women with MS were randomly assigned to a resistance-training group, an aquatic exercise group and a control group. After separating plasma and PBMCs from blood samples, level of plasma NT-4 and NT-4 expression was measured after eight weeks of exercise via ELISA and Real-time PCR, respectively.
        Results: The level of plasma NT-4 and NT-4 expression increased significantly following eight weeks of aquatic training and resistance training. 
        Conclusion: Based on the results of the present study, both resistance training and aquatic exercise can increase the level of plasma NT-4 and NT-4 expression in female MS patients. It can be concluded that such trainings could have protective and positive effects on the nervous system of MS patients.
        Keywords: Exercise, Multiple Sclerosis, Neurotrophic Factors, Women.
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Research Article: Original Paper |
Received: 2017/11/20 | Accepted: 2017/11/20 | Published: 2017/11/20 | ePublished: 2017/11/20

References
1. Makvandi Z, Sadeghi Haj M, Sarbrofzad A, Majidi Nasab N. The relationship between HH V-6 and HHV7 viruses with multiple sclerosis disease in Khuzestan province. 12th Iranian congress, Sari. 2015.
2. Nouri M. An Investigation and Comparison of the Increasing Scale of MS Exposure in Different Countries of the World. 12th Congress of ms of Iran, Sari. 2015.
3. Azadvari M, Kazemi Sh, Emami S. The Need for Urinary Problems in Women Affected by Multiple Sclerosis and its Treatment. balouchy R, ghiasi A, naderi E, sodoghi H. The survey of Cawthorne and Cooksey exercise on the quality of life, balance and fatigue in patients with multiple sclerosis. sjimu. 2014; 21(7): 43-53.
4. Reiisi S, Shahi H, Sanati MH. Gene Therapy in Multiple Sclerosis (MS). Genetics in the Third Millennium. 2014; 12(4): 3824- 3832.
5. Azoulay D, Urshansky N, Karni A. Low and dysregulated BDNF secretion from immune cells of MS patients is related to reduced neuroprotection. Journal of Neuroimmunology. 2008; 195(1-2): 186-193. doi: 10.1016/j.jneuroim.2008.01.010. [DOI:10.1016/j.jneuroim.2008.01.010]
6. Zangi M, Ofoghi H. Nerve growth factor, clinical applications and production of the recombinant protein. JQUMS. 2017; 20(6): 53-70.
7. Khan N, Smith MT. Neurotrophins and Neuropathic Pain: Role in Pathobiology. Molecules. 2015; 20: 10657-88. doi: 10.3390/molecules200610657. [DOI:10.3390/molecules200610657]
8. khalil nejhad A, zahed nasab H, khodabande lo H, mahmodian E, azar abdar T, balood M, et al . Diagnostic Biomarkers in Multiple Sclerosis. sjimu. 2014; 21(7): 288-311.
9. Motl R, Pilutti L. The benefits of exercise training in multiple sclerosis. Neurology. 2012; 8(9): 487-497. doi: 1038/nrneurol.2012.136.
10. Nazari Telaki Z, Abedini M, Nazari Telaki M. A recent study on the demographic characteristics of the clinical course of the disease, the trend in MS patients in Mazandaran and Kerman. 12th Iranian congress, Sari. 2015.
11. Moradi M, Kordi MR, Sahraian MA, Mehri K, Hosseini SH. The Effect of Eight-Week Resistance Training on Muscular Strength and Balance in Men with Multiple Sclerosis. 2012; 4(1): 5-22.
12. Mohammadi G, Naghibzade A, Rezaee Namjoo F, Rashidlamir A. the effects of massage and aqua training on interleukin-6 levels of multiple sclerosis patients. Edizioni Minerva Medica.2016; 175(10): 408-12.
13. Ferguson B. ACSM's guidelines for exercise testing and prescription. J Can Chiropr Assoc. 2014; 58(3): 328.
14. Whitem LJ, Dressendorfer RH. Exercise and multiple sclerosis. Sports Med. 2004; 34(15): 1077-1100. [DOI:10.2165/00007256-200434150-00005]
15. Rashidlamir A. Investigation of the Effect of Aerobic and Resistance Exercises on Peripheral Blood Mononuclear Cells ABCG1 Gene Expression in Female Athletes. JSSU. 2012; 20(1): 1-9.
16. Labouyrie E, Dubus P, Groppi A, Xavier Mahon F, Ferrer J, Parrens M, et al. Expression of Neurotrophins and their Receptors in Human Bone Marrow. American Journal of Pathology. 1999; 154(2): 405-415. [DOI:10.1016/S0002-9440(10)65287-X]
17. Ghanbari-Niaki A, Ghanbari-Abarghooi S, Rahbarizadeh F, Zare-Kookandeh N, Gholizadeh M, Roudbari F, et al. Heart ABCA1 and PPAR- α Genes Expression Responses in Male rats: Effects of High Intensity Treadmill Running Training and Aqueous Extraction of Black Crataegus-Pentaegyna. Res Cardiovascular Med. 2013; 1(5): 153-159. doi: 10.5812/cardiovascmed.13892. [DOI:10.5812/cardiovascmed.13892]
18. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta DeltaC(T)) Method. Methods. 2001; 25(4): 402-408. DOI:10.1006/meth.2001.1262. [DOI:10.1006/meth.2001.1262]
19. Mojtahedi S, Shabkhiz F, Akbarnejad A, Salehian O. Effect of 8 weeks Resistance Training on BDNF and TrkB in the Hippocampus of Adult Male Rats. Armaghane danesh. 2014; 19(5): 380-9.
20. Eslami R, Gharakhanlou R, Mowla J, Rajabi H, Mohammadkhani R. Effect of resistance exercise on protein content and mRNA expression of NT 4/5 in rat slow and fast muscles. Journal of Gorgan University of Medical Sciences. 2014; 16(1): 35-40.
21. Moghadasi M, Edalatmanesh M, Moeini A, Nematollahzadeh mahani M S, Arvin H. Effect of 8 weeks resistance training on plasma levels of nerve growth factor and interlukin-6 in female patients with multiple sclerosis. Iran South Med J. 2015; 18(3): 527-537.
22. Kalinowska-Lyszczarz A, Losy J. The Role of Neurotrophins in Multiple Sclerosis—Pathological and Clinical Implications. International Journal of Molecular Sciences. 2012; 13: 13713-25. doi: 10.3390/ijms131013713. [DOI:10.3390/ijms131013713]
23. Ylä-Kotola TM, Kauhanen MSC, Asko-SeljavaaraSL. P75 Nerve Growth Factor Receptor Is Expressed in Regenerating Human Nerve Grafts. Journal of Surgical Research. 2008; 146: 254-61. DOI:10.1016/j.jss.2007.05.028. [DOI:10.1016/j.jss.2007.05.028]
24. Moghani Ghoroghi F, Nobakht M, Esmaeilzade B, Bakhtiyari M, Hejazian LB. Effect of Neurotrophin-3 on differentiation of rat hair follicle stem cells into neural like cells. Journal of Iranian Anatomical Sciences. 2012; 9(37): 269-78.
25. Urshansky N, Mausner-Fainberg K, Auriel E, Regev K, Farhum F, Karni A. Dysregulated neurotrophin mRNA production by immune cells of patients with relapsing remitting multiple sclerosis. Journal of the Neurological Sciences. 2010; 295: 31-7. doi: 1016/j.jns.2010.05.019.
26. Shayan A, Bagherzadeh F, shahbazi M, choobineh S. The Effect of Two Types of Exercise the (Endurance and Resistance) on Attention and Brain Derived Neurotropic Factor Levels in Sedentary Students. 2015; 6(4): 433-52.
27. GoÂmez-Pinilla F, Ying Z, Opazo P, Roy R.R, Edgerton R. Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle. EuropeanJournalofNeuroscience. 2001; 13: 1078-84. [DOI:10.1046/j.0953-816x.2001.01484.x]
28. Ying Z, Roy RR, Edgerton R, Gomez- Pinilla F. Voluntary exercise increases neurotrophin-3 and its receptor TrkC in spinal cord. Brain Research. 2003; 987(1): 93-9. [DOI:10.1016/S0006-8993(03)03258-X]
29. Eslami S, Hakimi M, Ali-Mohammadi M, Karimiyani N. Comparing the effects of hydrotherapy, relaxation and McKenzie exercise on improvement of chronic low back pain in athletes. Journal of Anesthesiology and Pain official (JAP). 2014; 4(2): 11-21.
30. Masoodi Nejad M, Khosroo E, Shirvani H. Effect of combined training on strrngh muscle and functional capacity in women with multiple sclerosis. Journal sport physiology (research on sport science). 2013; 4(16): 81-96.
31. Sami S, Hakimi M, Ali-Mohammadi M, Karimiyani N. Comparing the effects of hydrotherapy, relaxation and McKenzie exercise on improvement of chronic low back pain in athletes. Journal of Anesthesiology and Pain official (JAP). 2014; 4(2): 11-21.
32. Shahnazari Z, Marandi S M, Shayegan Nejad V. The Effect of Pilates Exercises and Aquatic Trainning on Walking Speed in Women with Multiple Sclerosis. jgbfnm. 2013; 10(2): 10-17Yousefvand Z, Parnow A, Ahsan B, Fayazi B. Effect of 8-week resistance training on muscle strength and functional capacity in women with multiple sclerosis (MS). Journal of Sport in Biomotor Sciences. 2012; 6(2): 71-82.
33. Funakoshi H, Belluardo N, Arenas E, Yamamoto Y, Casabona A, Persson H, et al. Muscle derived neurotrophin-4 as an activity-dependent trophic signal for adult motor neurons. Science 1995; 268 (5216):1495-9. [DOI:10.1126/science.7770776]
34. Walker UA, Schon EA. Neurotrophin-4 is up-regulated in ragged-red fibers associated with pathogenic mitochondrial DNA mutations. Ann Neurol. 1998; 43(4): 536-540. [DOI:10.1002/ana.410430421]

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