Jorjani Biomedicine Journal
فصلنامه علمی پژوهشی زیست پزشکی جرجانی
Jorjani Biomed J
Medical Sciences
http://goums.ac.ir/jorjanijournal
1
admin
2645-3509
10.52547/jorjanibiomedj
en
jalali
1398
9
1
gregorian
2019
12
1
7
4
online
1
fulltext
en
The Association of Vitamin D Receptor Polymorphisms of FokI and TaqI with Rheumatoid Arthritis in North-East of Iran
علوم پایه پزشکی
Basic Medical Sciences
تحقیقی
Original article
<strong><em>Background and objectives:</em></strong> Vitamin D receptor (VDR) has been identified as a susceptibility gene for several autoimmune diseases. This study was designed to investigate the association of VDR gene polymorphisms with the susceptibility to rheumatoid arthritis (RA).<br>
<strong><em>Methods:</em></strong> A case-control study was performed on 130 RA patients and 128 healthy subjects in the north-east of Iran using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) technique. <br>
<strong><em>Results:</em></strong> Our findings suggested a significant association of T allele (p=0.01) of TaqI (rs731236), and f allele (p=0.01) of FokI (rs10735810) genetic variants of the VDR gene with RA susceptibility. These significant associations were also found in the T/T genotype of TaqI (p=0.009), and F/f genotype of FokI (P=0.014). The f-T haplotype was more significantly detected in-patients than in healthy controls (p=0.007).<br>
<strong><em>Conclusion</em></strong>: The RA group showed an increase in the f allele and heterozygous F/f genotype and also in the T allele and homozygous T/T and heterozygous T/t genotypes as compared to the control group. Our results demonstrated that polymorphisms of TaqI and FokI in the VDR gene might be involved in the development of RA in an Iranian population.<span dir="RTL"></span>
FokI,TaqI,Vitamin D receptor,Rheumatoid arthritis,restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR),
20
29
http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-563-5&slc_lang=en&sid=1
nafiseh
kaviani
kavianyn@yahoo.com
10031947532846005921
10031947532846005921
No
Department of Biology, Gorgan Branch, Islamic Azad University, Gorgan, Iran
yaghoub
yazdani
yaghoubyazdani59@yahoo.com
10031947532846005922
10031947532846005922
Yes
Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Hadi
Bazzazi
hadi.bazzazi@gmail.com
10031947532846005923
10031947532846005923
No
Department of Medical Laboratory Sciences, Gorgan Branch, Islamic Azad University, Gorgan, Iran