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Showing 3 results for Oxidative Stress
Oxidative Stress Balance as a diagnostic marker in Stroke
Mina Rahmati, Naser Mobarra, Hossein Ghannadan,
Volume 7, Issue 2 (7-2019)
Abstract
Background and objectives: Ischemic stroke (IS) is a life-threatening disease which lacks reliable prognostic and/or diagnostic biomarkers. In the present study, we examined the serum oxidative stress balance (OSB) and evaluated its diagnostic and prognostic value for IS.
Methods: Sera from 52 IS patients and 52 sex- and age-matched healthy volunteers were obtained. All patients were subjected to the collection of samples at the time of admission, 24 and 48 hours later, at the time of discharge and three months later. OSB levels were assessed by spectrophotometry. Statistical analyses for diagnostic accuracy of quantitative measures were performed.
Results: We showed that OSB levels were elevated at the time of admission in comparison to normal subjects. ROC curve analysis expressed that OSB could be an acceptable diagnostic marker to discriminate IS patients from normal subjects (AUC = 0.7337; P<0.0001). Kaplan-Meier survival analysis showed that OSB had no prognostic value (P=0.8584).
Conclusion: Oxidative stress balance could be introduced as a suggested biomarker to segregate IS patients from normal subjects.
The Effect of Eight-week Swimming Exercise and Gallic Acid on Hippocampal BDNF and Oxidative Stress Parameters in Trimethyltin Induced Cognitive deficits
Samaneh Rafiei, Ali Asghar Ravasi, Abbas Ali Gaeini,
Volume 9, Issue 1 (3-2021)
Abstract
Background and Objective: Trimethyltin (TMT) is an organotin neurotoxin which causes cognitive disorders by the induction of selective damage in hippocampus. The present study evaluates the effect of 8-week swimming exercise (EX) and Gallic acid (GA) for working and avoidance memory, hippocampal oxidative stress indices and brain neurotrophic factor expression (BDNF) in rats after TMT intoxication.
Material and Methods: In this experimental study, 40 Wistar mature male rats were randomly put in 5 groups of control, TMT+NS, TMT+GA200, TMT+EX, TMT+GA200+EX. 24 hours after TMT intoxication (8mg/kg), 8 weeks of swimming exercise (3 sessions per week), and treatment with GA (200mg/kg) were done. Then, the evaluation of working and passive avoidance memory was performed respectively by the use of Y maze and shuttle box. Hippocampal level of catalase (CAT), total antioxidant capacity (TAC) and BDNF were done by ELISA method, and content of malondialdehyde (MDA) was performed by thiobarbituric acid (MDA). Statistical differences between groups were analyzed by two-way ANOVA and Bonferroni post hoc test.
Results: The significant decrease in the percentage of alteration behaviors, latency time to the dark room, along with BDNF, CAT, TAC and increase of MDA were seen in TMT+NS group compared to control group (p<0.01). Swimming exercise in the interaction with GA ameliorates working and avoidance memory by increasing BDNF, CAT, TAC, and decrease of MDA compared to TMT+NS group (p<0.05).
Conclusion: It seems that swimming exercise and GA administration improves cognitive symptoms following TMT intoxication simultaneously by decreasing oxidative stress and increasing BDNF expression.

The Health-Related Biological Effects of Date Palm Pollen (DPP) along with Physical Activity: A Narrative Mini-Review
Soheil Abdollahi, Mohammad Ali Azarbayjani, Maghsoud Peeri, Saleh Rahmati-Ahmadabad,
Volume 10, Issue 4 (12-2022)
Abstract
Date Palm Pollen (DDP), which is found in the male date tree, actually fertilizes the female date tree, which is necessary for the growth of date fruit. It is consisting of sugarcane, protein, calcium, vitamins (B, C and E) and minerals. It has long been used in traditional medicine as a medicinal plant with fertility effects and increased libido. The information obtained from the studies shows that this pollen, due to its antioxidant and gonadotropin-stimulating compounds, can increase fertility and sexual potency in both women and men with two main mechanisms. The first mechanism is this effect on the stimulation of gonadotrophic hormones and the second is a reduction of oxidative stress in the testicular tissue and consequently a protective effect on the testicular tissue. Due to the presence of antioxidant compounds, the consumption of this pollen also applies its health-enhancing effects to other tissues such as the liver, intestines, and heart. As same as DDP, regular Physical Activity (PA) stimulates gonadotrophic hormones and also beneficially affects antioxidant status and redox balance. In recent years, researchers have paid attention to this pollen as an important factor to strengthen the health-enhancing effects of PA, and researchers have investigated the simultaneous effect of this pollen and PA. Despite the few studies done, it seems that this pollen can enhance the antioxidant and anti-inflammatory effects of regular PAs. Nevertheless, it seems necessary to further studies in this area.

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