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Soheila Meimanat Abadi, Dr Fazlullah Ghofranipour, Dr Faegh Yousefi, Farhad Moradpour,
Volume 4, Issue 1 (5-2016)

Background and Objectives: Damages caused by accidents are accounted as a major cause of death for children under 5 years old. To design preventive programs, health education theories could be employed. This study aimed to determine the effect of educational intervention based on health belief model on the damage caused by accidents in children less than 5 years in 1392 in Qorveh city.

Methods: The present randomized field trial study was conducted on 120 mothers with children less than 5 years who were supported by four different health centers. These centers were randomly divided into two groups of intervention and control. The effect of intervention was investigated using a standardized questionnaire including 85 items of health belief model structures. The questionnaires were completed using interviews by trained interviewers. Statistical analysis was done using SPSS 19.0, independent and two-tailed samples t-test.

Results: We found that there were positive and significant differences in terms of knowledge, intensity, perceived barriers and self-efficacy between two groups after intervention (P<0.05). Average differences before and after the intervention and the average scores were significantly different in all cases (P<0.05). There was a significant difference regarding the mild injuries among children under five years between the two groups after intervention (P=0.023).

Conclusion: Our results showed that education on the basis of health belief model, as one of the theories of health education, has positive effects on the promotion of safety knowledge, attitude change and improving the function of mothers over damaged children lower than 5 years and consequently the promotion of health and safety among children.

Habib Onsori, Davood Poladi, Mehdi Valizadeh, Afshin Fathi, Mahshid Damandan, Rouhallah Moradpour,
Volume 8, Issue 3 (10-2020)

Background and objective: Glucose 6-phosphate dehydrogenase (G6PD) deficiency is one of the most common human diseases with approximately 400 million people affected worldwide. G6PD Chatham is caused by 1003 G>A mutation leads to a severe enzymatic deficiency. The aim of the present study is to investigate the frequency rate of the Chatham mutations in the population of the North-West of Iran.
Material And Method: In this study, by Rapid Genomic DNA Extraction (RGDE) method, from 90 peripheral blood samples of unrelated male and female patients with genetic deficiency of G6PD, DNA was extracted and after digestion by Bstx1 enzymes, in order to search for Chatham mutation, they were analyzed by means of PCR-RFLP and sequencing methods.
Result: According to the results, Chatham mutation was observed in 10 samples (11.11%).
Conclusion: This study showed that G6PD Chatham (1003 G>A) mutation is the second common mutation, after Mediterranean (563C>T), in the population of the North-West of Iran. Further studies are recommended to identify the mutation type of other varieties.

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