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Comparison of Injective and Contact Effect of Silver Nanoparticles on The Rate of Hemoglobin Changes in Male Rats
Zahra Amirkhani Dehkordi, Nooshin Naghsh, Heydar Aqbaba,
Volume 1, Issue 1 (10-2012)
Abstract

Background and objective:

The use of silver nanoparticles is one of the functional areas of nanotechnology. These nanoparticles have an antibacterial and antifungal quality. The active ions released form silver nanoparticles can produce free radicals and damage different types of cell. Considering the importance of hemoglobin, this study investigates Comparison of injective and contact effect of silver nanoparticles on the rate of hemoglobin changes in male rats.

Materials and Methods:

In this experimental study were 72 male adult Wistar rats with a mean weight of 225 to 250 grams. The animals were randomly divided into ten groups of eight rats. Nanoparticles were administered to treatment groups using the injective method through intraperitoneal (IP) and the skin contact method with concentrations of 50, 100, 200, and 400 ppm. In order to assimilate the shock resulted by injection and contact, physiologic serum of the same amount was injected to rats of control group or contacted to their skin. Then, blood was drawn from the internal corner of the rats’ eye using capillary tubes. The mean level of hemoglobin in the rats’ blood in the treatment and control group was compared 12 days after the treatment. To compare the means, ANOVA test was used.

Results:

The results showed the dependence of dose and the rate of hemoglobin changes in intraperitoneal injection and the lack of effect of silver nanoparticles on hemoglobin changes in skin contact.

Conclusion:

The effectof the injection of silver nanoparticles on the rate of hemoglobin has been dose-dependent. But the skin contact method has had no effects on the rate of hemoglobin. It seems that a low concentration of nanoparticles and a short period of time cause a lack of effect on the factor.
Comparing learning styles among students of Para medicine and Health faculties in Golestan University of medical sciences
Ghorban Mohammad Koochaki, Behrooz Kord, Senieh Sotoodeh, Mansoureh Tatari,
Volume 4, Issue 1 (5-2016)
Abstract

Background and Objectives: The validity of an educational system is dependent on students' learning. Learning is a complex variable which is affected by multiple factors. One of the most important factors is learning styles. Knowledge of learning styles of students to educational programs is very important. Therefore, this study aimed to determine students' learning styles among students of Para medicine and Health faculties in Golestan University of medical sciences.

Methods: In this cross-sectional study, 401 students of the faculty of Para medicine and Health in Golestan University of Medical Sciences since 1391 till 1392 were selected and filled out the Standard Kolb Learning Style Inventory (LSI) which was previously tested for reliability (8.0). Data was analyzed with SPSS version 18.0 using Chi-square and Fisher's exact test.

Results: The mean age of students was 20.57 and 71.8 percent of them were female students. Learning styles of students included a convergent (63.4 %), absorber (25.4 %), accommodating (7.5%) and divergent (3.7 %). Learning style of study had no statistically significant difference in comparison to sex, school, age, GPA, credits, semester and education levels (P>0.05).

Conclusion: Converging and absorbing learning styles were more dominant among students. Therefore, it is recommended to use training methods which fit this style such as showing hand-writings and presentations with self-study materials, simulations, laboratory assignments and problem-based learning.


Eight Weeks of Swimming Training and CBD Oil Consumption Downregulates the Expression of MAPK and PPARα Genes in the Heart Tissue of Myocardial Infarction Rats
Ali Mohammadnia, Khosro Jalali Dehkordi, Gholamreza Sharifi,
Volume 9, Issue 3 (10-2021)
Abstract
Background and Objective: The application of exercise training and herbal supplements is believed to be a typical approach in treating chronic diseases and metabolic disorders. Accordingly, given the healing effects of swimming training and cannabidiol (CBD) oil consumption, the aim of the current study was to reveal if eight weeks of swimming training and CBD oil consumption downregulates the expression of MAPK, PPARα genes in the heart tissue of myocardial infarction rats.
Material and Methods: In the present experimental study, 20 myocardial infarction rats were divided into four groups of five animals, including: 1) control, 2 swimming training, 3) CBD, 4) CBD + swimming training, and 5) healthy control. For eight weeks, groups 3 and 4 consumed 50 mg/kg of CBD daily by gavage, and groups 2 and 4 performed swimming training five days a week. Induction of myocardial ischemia was performed by subcutaneous injection of isoproterenol (50 mg/kg i.p.), in myocardial infarction rats. Bax and Bcl2 cardiomyocytes were measured by PCR-RT. For data analysis, one-way analysis variance test was used to compare inter-group differences at P<0.05.
Results: Swimming training, CBD consumption and swimming training with CBD consumption had a significant effect on reducing MAPK gene expression in cardiac tissue (P≤0.05). Also, swimming training with CBD consumption had a greater effect than swimming training and CBD consumption alone on reducing PPARα gene expression in cardiac tissue (P≤0.05).
Conclusion: It appears that application of swimming training with CBD oil consumption has more positive impacts on improving MAPK and PPARα gene expression levels in the heart tissue of rats with myocardial infarction than using each one alone. Besides, swimming training with CBD oil consumption plays a role in the rehabilitation process and improves key factors involved in cardiovascular health.

The Effect of Aerobic Training with Royal Jelly Consumption on Health Related Anthropometric Markers in an Experimental Autoimmune Encephalomyelitis Model
Abdolhamid Mosalla Nezhad, Farzaneh Taghian, Khosro Jalali Dehkordi, Seyed Ali Hosseini,
Volume 9, Issue 4 (12-2021)
Abstract
Background and Objective: Interactive effects of Aerobic Training (AT) and Royal Jelly (RJ) consumption is still not well understood in Multiple Sclerosis (MS). Therefore, the aim of this study was determine the effect of aerobic training with royal jelly consumption on health related anthropometric markers in an Experimental Autoimmune Encephalomyelitis (EAE) model.
Material and Methods: 49 EAE induced by complete Freund’s Adjuvant, model female Sprague-Dawley rats were assigned to 7 groups: (1) EAE, (2) sham (Sh), (3) RJ50 mg/kg, (4) RJ100, (5) AT, (6) AT+RJ50, (7) AT+RJ100. Also, 7 healthy rats were put in the healthy control group (HC). AT was performed for five weeks, four sessions per week at a speed of 11-15 m/min for 30 minutes and RJ was IP injection for 50 and 100 mg/kg/day.
Results: In the AT, AT+RJ50, AT+RJ100 and RJ100 groups, weight, visceral fat weight and aerobic power were higher than the EAE group (P≥0.05); in the RJ50 group, weight and in the RJ100 and AT+RJ100 groups, BMI was lower than the EAE group (P≥0.05). AT+RJ100 reduced food intake compared to the EAE group (P≥0.05); also, aerobic power in the AT, AT+RJ50 and AT+RJ100 groups was higher than the RJ50 and RJ100 groups (P≥0.05).
Conclusion: Generally AT and RJ alone improved anthropometric markers in EAE model; also interaction of AT and RJ was dependent of dosage of RJ so that the effect of 100 mg/kg dosage was higher than 50 mg/kg.

Exploring the effects of aerobic exercise combined with chitosan nanoparticle-encapsulated ginger on miRNA-214 and SERCA2a in isoproterenol-induced myocardial infarction in rats
Vahid Fallahzadeh, Farzaneh Taghian, Khosro Jalali Dehkordi,
Volume 11, Issue 3 (12-2023)
Abstract
Background: Aerobic exercise and ginger after myocardial infarction (MI) modify calcium handling. Ginger has cardioprotective effects on cardiovascular disease. This study assessed the effects of aerobic exercise combined with ginger extract (GE) loaded into chitosan nanoparticles (CNPs) on miRNA-214, Serca2a, and Anp genes and cardiac fibrosis in myocardial infarction (MI) rat models.
Methods: Twenty-five male rats divided into 5 groups were subjected to ginger treatment and exercise. Aerobic exercises (AE) were performed on a rodent treadmill 5 days per week for 6 weeks. The GE-CNPs (500 mg/kg) were orally administered to the rats for 6 weeks. The expressions of miRNA-214, Serca2a, and Anp genes were assessed by real-time polymerase chain reaction (PCR). The histopathological assessments were performed using hematoxylin and eosin (H&E) and Masson's trichrome staining. The serum activities of creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) were also measured by ELISA.
Results: The MI model and CNP groups had the highest rate of collagen deposition (P <0.05). The serum activities of both CK-MB and LDH were significantly elevated in the Isop group compared to the control (P<0.05), while following aerobic exercise and ginger treatment, their activity was significantly dropped in the Isop + AE + GE-CNPs group. The expression of miRNA-214 showed a significant increase in GE-CNPs (P <0.01) and GE-CNPs + AE (P <0.001) groups. Serca2a and Anp genes showed significant changes in the GE-CNPs + AE group (P<0.05).
Conclusion: Our findings revealed that aerobic exercise, along with ginger treatment, improved cardiac fibrosis, modulating the expression levels of miRNA-214, Serca2a, and Anp genes and serum levels of MI biomarkers.
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