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Showing 4 results for yazdani

Farzaneh Afkhaminia, Dr Jamshid Yazdani Charati, Elaheh Rahimi, Dr Nourodin Mousavi Nasab,
Volume 6, Issue 1 (3-2018)
Abstract

Background and objectives: Road accidents are one of the most important causes of mortality and severe physical and psychological damage which may lead to adverse social, cultural and economic consequences in the human community. Frequency and severity of road accidents in developing countries are noticeably higher in comparison to developed countries. In Iran, 25% of casualties are due to the abnormal deaths caused by road accidents. It is estimated that more than 22,000 people die due to road accidents every year. The present study aimed to epidemiologically investigate the mortality rate of suburban accidents in Golestan province, Iran.
Methods: This cross-sectional study was conducted using a descriptive approach. Required data were obtained from the traffic police of Golestan province. In total, 2,922 cases of road accidents were investigated in Golestan province in 2015. The analyzed data included the demographic characteristics of the deceased and the environmental and geographical conditions of the accident. Data analysis was performed in SPSS version 20.
Results: Among 2,922 road accidents in Golestan province, 251 cases led to the death of 317 individuals. Most of the accidents leading to death were by automobiles (69.7%) and due to distraction from the road (33.1%), which occurred on main roads (47.8%). Moreover, 29.7% of guilty drivers had not fastened seatbelts. Motorcycle riders and car passengers accounted for the highest percentage of accident victims (30.6% and 25.5%, respectively).
Conclusion: Education and emphasis on the use of seatbelts and motorcycle helmets while driving seem essential to reducing the injuries caused by road traffic accidents. Considering that most road accidents occur due to the distraction of the driver from the road, changing traffic behaviors to improve discipline is of paramount importance.
Golnesa Dadkhah, Hadi Bazzazi, Yaghoub Yazdani,
Volume 6, Issue 3 (9-2018)
Abstract

Background and objectives: Rheumatoid arthritis (RA) is a complex and systemic inflammatory disease in which the immune response is disturbed. Single nucleotide polymorphisms (SNPs) in the promoter regions of regulatory cytokines including interleukin-10 (IL-10) may lead to exacerbated immune response and increased risk of RA. Here, we aimed to assess the association of IL-10 -1082 (G/A) (rs1800896) promoter polymorphism with the susceptibility to RA in a population in northeast of Iran.
Methods: A total of 130 RA patients and 128 sex- and age- matched healthy donors were enrolled. The polymerase chain reaction (PCR) was used to amplify the polymorphic regions and restriction fragment length polymorphism (RFLP) technique was applied to detect rs1800896. SPSS 22.0 software was used to analyze data statistically.
Results: Our findings revealed that G allele was significantly associated with the increased risk of RA [OR = 1.88, 95% CI (1.32–2.66), P-value = 0.0001] in patients. Setting AA genotype as the reference, the AG [OR = 2.93, 95% CI (1.68–5.12), P-value = 0.0001] and GG [OR = 5.73, 95% CI (2.30–14.23), P-value = 0.0001] genotypes were significantly associated with RA susceptibility.
Conclusion: The present study suggests that the IL-10 -1082 (G/A) genetic variants are associated with RA susceptibility, but not with the disease activity. While this is the first time to report such an association in a population in northeast of Iran, further studies are needed to confirm these findings.
Sahar Ghovanjzadeh, Hadi Bazzazi, Yaghoub Yazdani,
Volume 6, Issue 3 (9-2018)
Abstract

Background and objectives: Rheumatoid arthritis (RA) is an autoimmune disease with a complex genetic background. The protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a lymphoid specific protein tyrosine phosphatase which is involved in negative regulation of T cell response. Several studies have assessed the association between PTPN22 single nucleotide polymorphisms (SNPs) with RA susceptibility. Here, we aimed to assess the association of PTPN22 (1858 C>T) variant with the susceptibility to RA in northeast of Iran.
Methods: A total of 127 RA patients and 119 age- and sex- matched healthy donors were enrolled. The polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) technique (PCR-RFLP) was applied to detect PTPN22 (1858 C>T) SNP. SPSS 22.0 software was used to analyze data using relevant statistical tests.
Results: Comparison of allele and genotype frequencies of PTPN22 (1858 C>T) SNP in RA patients and healthy donors revealed no significant association with RA susceptibility.
Conclusion: The present study suggests that the PTPN22 (1858 C>T) genetic variants are not associated with RA susceptibility and disease activity. While this is the first report from northeast of Iran, further studies are needed to confirm these findings
Nafiseh Kaviani, Yaghoub Yazdani, Hadi Bazzazi,
Volume 7, Issue 4 (12-2019)
Abstract

Background and objectives: Vitamin D receptor (VDR) has been identified as a susceptibility gene for several autoimmune diseases. This study was designed to investigate the association of VDR gene polymorphisms with the susceptibility to rheumatoid arthritis (RA).
Methods: A case-control study was performed on 130 RA patients and 128 healthy subjects in the north-east of Iran using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) technique.  
Results: Our findings suggested a significant association of T allele (p=0.01) of TaqI (rs731236), and f allele (p=0.01) of FokI (rs10735810) genetic variants of the VDR gene with RA susceptibility. These significant associations were also found in the T/T genotype of TaqI (p=0.009), and F/f genotype of FokI (P=0.014). The f-T haplotype was more significantly detected in-patients than in healthy controls (p=0.007).
Conclusion: The RA group showed an increase in the f allele and heterozygous F/f genotype and also in the T allele and homozygous T/T and heterozygous T/t genotypes as compared to the control group. Our results demonstrated that polymorphisms of TaqI and FokI in the VDR gene might be involved in the development of RA in an Iranian population.

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