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Farah Nameni, Siavash Shahdusti, Majid Hashemi,
Volume 9, Issue 1 (3-2021)

Background and Objective: Clinical studies have indicated, that exercise activity and supplementation may have different effects on heart function and health. The aim of this study was to assess the effects of weight training with whey protein supplementation on ANP, BNP, and Galactin-3 in 60-65 years old sedentary men.
Material and Methods: This study was based on a quasi-experimental design. The sample population was selected from volunteers out of the Kahrizak charity sanitarium of the Tehran province. Forthy men were randomly assigned to 4 groups (control, exercise, whey protein, and exercise + whey protein). Whey protein and exercise + whey protein groups were asked to consume whey protein. Training protocol lasted for 6 weeks. Blood levels of ANP, BNP, and Galactin-3, before and after the study were measured. Normality and variance heterogeneity was assessed using Shapiro-Wilk and Levenechr('39')s tests respectively. The significance of differences between training and supplementation groups was assessed by ANOVA and LSD hock post-test.
Results: The results showed that weight training program and in combination with whey protein supplementation significantly reduced Atrial natriuretic peptide (P=0.001), Brain natriuretic peptide (P=0.001), and Galactin-3 (P=0.001), compared to the control group (P<0.01).
Conclusion: The reduction of cardiac injury indices and structural and physiological recovery and the increase of cardiac function have been affected by the synergy of his training and protein.

Farah Nameni, Fatemeh Jafary Nia, Bahareh Yazdanparast Chaharmahali,
Volume 9, Issue 2 (6-2021)

Background and Objective: Autophagy is a genetically and evolutionarily conserved the programmed process that destroys long-lived cellular proteins and organelles. This study aimed to evaluate the effect of eight weeks of strength training with alpha-lipoic acid supplementation on LC3-I and P62 in elderly diabetic rats.
Material and Methods: In this experimental study, 35 old male Wistar rats were randomly divided into 5 groups (healthy control, diabetic, diabetic + strength training, Diabetic + supplement, Diabetic + strength training + supplement). First, the rats became diabetic and had a fatty liver. Strength training program in 10 weeks performed. Alfa-lipoic acid supplement was also injected 3 days a week. At the end of the training period and tissues were removed and the expression of LC3-I and P62 were measured by RT-PCR. For data analysis, a one-way analysis variance test was used for comparison between groups was considered (P<0/05).
Results: The result showed mRNA LC3-1 has increased and this change is more in the diabetic group. (P=0.001) and  despite the decrease in P62 gene expression, we did not see a significant difference between the control group and the diabetic in the training group with and without supplementation.However, no significant difference was observed between training methods and supplementation with exercise. Also, resistance training in combination with alpha-lipoic acid supplementation had a significant effect on reducing P62 content between control and experimental groups. (P=0.001).
Conclusion: Alfa-lipoic acid supplement with anti-oxidant and anti-inflammatory effect along with exercise can play an important role in improving fatty liver in elderly type 2 diabetic rats.

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