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Showing 12 results for Mohammadi

Dr Khaled Aslani, Ali Mohammadi, Zahra Rezaee Nia,
Volume 4, Issue 1 (5-2016)

Background and objectives: Nowadays, it is noteworthy to consider the nature of lovemaking as an important issue in social psychology and individual personality assessment. Therefore, this study was done aiming to compare the social anxiety, dysfunctional attitudes and body image in three groups of lovemaking in the real world, lovemaking in the virtual world and without lovemaking.

Methods: This is a descriptive study of causal – comparative type. The study population includes all male and female students of Shahid Chamran University in the academic year of 2014-15. A sample size of 300 students was selected using snowball sampling method. Data collection tools were: Social Anxiety Disorder (SAD), Dysfunctional Attitude Scale (DAS) and Multidimensional Body – Self Relations Questionnaires (MBSRQ). Data were analyzed using SPSS 16.0 and ANOVA Multivariate Analysis.

Results: We showed that a significant difference exists between scores of social anxiety, body image and dysfunctional attitudes in three groups of lovemaking in the real world, virtual world and without lovemaking (P < 0.0001). Our results revealed that the body image, social anxiety and dysfunctional attitudes in real world lovemaking group compared to virtual lovemaking and without lovemaking is significantly different and has a lower level. Body image, social anxiety, and dysfunctional attitudes in virtual lovemaking were also significantly different and had a lower level (P < 0.0001).

Conclusion: The results of this study could be helpful in pre-marriage and awareness counseling to people about the types of relationships and promotion of healthy communication patterns in society.

Samira Shakerizadeh, Mohammadi Shekari, Abdolazim Nejatizadeh, Aliakbar Poursadegh Zonouzi, Hedieh Fardmanesh, Ahmad Poursadegh Zonouzi,
Volume 4, Issue 2 (10-2016)

Background and objectives: Deregulation in the expression of microRNAs is involved in the pathogenesis of various malignancies. Impaired microRNAs processing pathway is one possible mechanism for global deregulation of the miRNAs. Exportin 5 (XPO5) is a key member of this pathway that links nuclear and cytoplasmic steps of miRNAs biogenesis together. XPO5 deregulation has been reported in some cancers but very little is known about its role in breast cancer. Therefore, this study aimed to evaluate the mRNA expression of XPO5 in breast cancer in an Iranian population.

Methods: In this case-control study, 30 tumoral tissues and 30 tumor-free margins were collected from breast cancer patients. After RNA extraction and cDNA synthesis, XPO5 mRNA expression level was assessed using quantitative Real-Time PCR.

Results: Our results showed that XPO5 was overexpressed in 53.3% of tumoral tissues but the difference in the gene expression level between tumoral tissues and tumor-free margins was not statistically significant (P-value=0.834). XPO5 expression level showed no statistically significant correlation and association with clinical and pathological parameters.

Conclusion: Overexpression of XPO5 in large percent of patients indicates that high level of XPO5 expression may be a tumorigenic factor for breast cancer which needs to be investigated more deeply.

Dr Mohammad Shokrzadeh, Reza Hoseinpoor, Dr Amir Hajimohammadi, Azam Delaram, Yaghoub Shayeste,
Volume 5, Issue 2 (10-2017)

Background & Objective: Poisonings are of the major public health challenges. Non-medicinal poisonings are of the most common types and causes of referring to medical centers worldwide. The present study was aimed to determine the non-medicinal poisonings pattern in adults of Gorgan city.
Methods: The present cross-sectional study was conducted on all non-medicinal poisoned patients referred to the 5Azar hospital from 2008 – 2015. Data were collected on checklists using census data collection method and were analyzed by Stata 11.0 software using Pearson’s Chi- square test.
Results: Of all 800 admitted poisoning cases, 227 individuals were non-medicinal and mostly male (72.7%). The ages of 34.4 % of cases were between 20 and 29 years. Moreover, 68.7% of all cases were living in urban areas, 57.7% were married and 27.8% were educated up to high school. Poisonings mostly occurred during summer (30%) and intentional (suicidal) poisonings were known as the major form (47.1%). Opium and aluminum phosphide were the most important poisoning agents (54.2%). Finally, 29 patients (12.8%) had passed away where aluminum phosphide poisoning was the main reason (55.2%).
Conclusion: Intentional poisonings by opium and aluminum phosphide were identified as the main causes of non-medicinal poisonings. It is necessary to emphasize on educational programs, prevention methods and general awareness.

Fatemeh Karimimanesh, Dr Mohammad Davarpanah Jazi, Dr Nooshin Mohammadifard,
Volume 5, Issue 2 (10-2017)

Background & Objective: Health databases contain a large amount of clinical data. Investigating the relationships and patterns in these databases can lead to new medical knowledge. Nutrition indicators are designed to evaluate the dietary quality in communities. Metabolic syndrome is a set of risk factors which may increase the risk of heart disease. Inappropriate diet is one of the most important factors in the occurrence of metabolic syndrome. The health industry is constantly producing a large amount of data in medical areas which requires a technique to disclose useful information and important relationships. The aim of this study was to compare the dietary diversity score (DDS) with healthy eating index (HEI) in terms of nutrient intake and assessing the association with metabolic syndrome with the approach of data mining.
Methods: A total of 1019 teenagers between the ages of 11 to 18 years were enrolled in this study.  Data were collected using a past 24-hour food frequency questionnaire (FFQ). Nutrition data collection and determination of anthropometric characteristics and medical examinations were performed in Isfahan Cardiovascular Institute. Data were analyzed by TANAGRA data mining tool.
Results: Statistical, regression and classification techniques were used for data exploration. The average score of DDS was 3.98 ± 1.10, while the HEI average was 59.23 ± 8.84 and the prevalence of metabolic syndrome was 17.39%. The average of DDS provided a better nutritional value in comparison to HEI. HEI was more robust in controlling received energy and carbohydrates. DDS was not significantly correlated with any of the components of metabolic syndrome, while HEI was weakly correlated with high waist circumference. High quartiles of HEI could predict a lower risk of metabolic syndrome, while high quartiles of DDS can predict higher risk of metabolic syndrome.
Conclusion: The findings of this study revealed that the DDS score may result in better nutrition uptake while adhering to the HEI was more effective in reducing the risk of metabolic syndrome.

Dr Alireza Norouzi, Dr Mohammadkazem Fakhri, Razieh Talebi, Dr Gholamreza Roshandel, Reza Mohammadi,
Volume 5, Issue 2 (10-2017)

Irritable Bowel Syndrome (IBS) is the most common functional gastrointestinal disorder and is a psychosomatic disorder. This study aimed to determine the effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) on coping styles and gastrointestinal symptoms of IBS patients. This Experimental (pretest-posttest with the control group) study was conducted on 32 patients with IBS based on inclusion and exclusion criteria. They divided randomly assigned into two groups intervention (n = 15) and control (n = 17). ROME III was used for the diagnosis of IBS. coping styles were evaluated by using Lazarus coping styles questionnaire (CSQ). Data analysis was conducted in SPSS software by using student t-test, Mann-Whitney, and covariance. The results showed that the difference between the mean scores of coping styles (emotion-focused & problem-focused) and gastrointestinal  symptoms in the intervention group after the sessions of mindfulness-based cognitive therapy was statistically significant (p <0.01). The results show that mindfulness-based therapy can be effective in reducing and controlling psychological symptoms, enhance well-being and quality of life. Therefore, this therapy as an adjunctive therapy in patients with irritable bowel syndrome is recommended.

Zeynab Haj Mohammadi, Shamsozoha Abolmaali, Azim Akbarzadeh,
Volume 6, Issue 2 (6-2018)

Background and objectives: Prostate cancer is the second leading cause of mortality among men worldwide, and the eighth cancer-related cause of death in Iran. Male sex hormones (androgens) are the main cause of prostate cancer cells. Triptorelin is considered a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH) in the treatment of prostate cancer. This study aimed to evaluate the methods to deal with the constraints in use of lipid nanoarchaeosomes. Due to their adjuvant feature and presence of ether links, archaeosomes are more stable in blood, compared to other lipid-based formulations. In the present study, the effects of nanoarchaeosomes containing triptorelin acetate on the cellular toxicity of the PC3 prostate cancer cell line were evaluated.
Methods: Halobacterium salinarum bacteria were cultured in HS medium, and their polar lipids of the membrane were removed applying the Blight&Dye technique in order to obtain nanoarchaeosome containing membrane polar lipids. In the next stage, nanoarchaeosomes were prepared by the hydration of polar lipids. In addition, cell viability was evaluated using the MTT assay on the PC3 cell line.
Results: In this research, mean diameter of the drug-containing nanoarchaeosomes was estimated at 263 nm using the ZetaSizer device. Moreover, drug loading efficiency of nanoarchaeosomes was estimated at 98%. Furthermore, the toxicity of the free and nanoarchaeosome drugs was assessed via the MTT assay, results of which were indicative of a mean of IC 50 0.22 µg/ml in this regard.
Conclusion: According to the results of the study, archaeosomes extracted from polar lipids were produced with high concentration and purity on the nanoscale. Considering the high stability, ease of production, level of drug loading, and toxic effect on cancer cells, nanoarchaeosomes can be used as a suitable technique for targeted drug delivery in future studies. 
Masoud Aman Mohammadi, Mohammad Reza Rostami, Mojtaba Raeisi, Mahnaz Tabibi Azar,
Volume 6, Issue 4 (12-2018)

Preparation of nano-microfibers from biopolymers (e.g., proteins and polysaccharides) by using electrospinning technology has been considered by researchers due to the formation of fibers or particles at the nano and micrometer scales, high porosity level, adjustable dewatering behavior, and special mechanical behavior. These products can be used in the microencapsulation of bioactive compounds, stabilization of enzymes and smart packaging. In the electrospinning method, a high voltage is used to create a nanofibers-particles. When the electric field overcomes the surface tension of the droplet, a jet exits the polymeric solution and is formed along the collector surface as it stretches toward the collector panel of the nanofiber. Parameters including molecular weight and polymer microstructure characteristics such as electrical conductivity, viscosity, surface tension, and the electrical potential applied by the device, solution flow rate, distance between the tip of the needle and the collector plate and sometimes the material of the collector plate are effective in the formation of electrospun fibers and particles. In this review, we discussed and evaluated the production stages, the strengths and weaknesses of the fibers produced from proteins and polysaccharides, and their functional properties and potentials, especially in food and drug sciences.
Faezeh Ajam, Mehrdad Aghaei, Saeed Mohammadi, Mohsen Saeedi, Nasser Behnampour, Ali Memarian,
Volume 7, Issue 2 (7-2019)

Study objectives: Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune disease, characterized by inflammation and the destruction of the joints. It is well known that CD4+ T cells play a major role in the pathogenesis of RA. Expanded subpopulations of CD4+ T cells have been reported in RA patients. Here, we investigated the expression of PD-1 on subsets of CD4+ T cells (CD4+CD28- and CD4+CD28+ T cells) in the peripheral blood (PB) and synovial fluid (SF) of patients with RA.
Methods: A total of 42 RA patients, including 10 newly diagnosed (ND) and 32 relapsed (RL) cases and also 20 healthy controls were enrolled. Phenotypic characterization subsets of CD4+ T cells were evaluated by flow cytometry, using fluorescence conjugated specific human monoclonal antibodies.
Results: The frequency of CD4+CD28+ T cells was significantly increased in SF versus PB in ND and RL patients. In contrast, the percentage of CD4+CD28- T cells was elevated in PB of ND and RL patients comparison to SF. Expression of PD-1 on CD4+CD28+ and CD4+CD28- T cells in PB of ND and RL patients was significantly higher than the healthy controls. Furthermore, PD-1 expression on CD4+CD28+ and CD4+CD28- T cells in SF versus PB of RL patients were significant increased.
Conclusion: These data suggest that CD4+ T cells subsets in RA patients were resistance to PD-1 mediated effects and PD-1 has insufficient ability to suppression of CD4+T cells.
Saeed Mohammadi,
Volume 7, Issue 4 (12-2019)

Aryl hydrocarbon receptor (AHR) signaling has been introduced to be involved in macrophages polarization. The perturbation of AHR has been reported in hypoxia and related disorders. Here, I would like to highlight the significance of AHR in hypoxia-mediated macrophages polarization and suggest conducting further experiments on related subjects.

Eraj Baghery Nasab Najaf Abad, Ali Khajehlandi, Amin Mohammadi,
Volume 8, Issue 1 (3-2020)

Background and objective: Type 2 diabetes (T2D) is a metabolic disease that leads to increased levels of lipids, therefore the present study aimed to investigate the effect of eight weeks of aerobic training(AT) with silymarin (S)consumption on lipid profile in men with type 2 diabetes.
Material and Methods: 60 middle-aged male volunteers were randomly divided into 4 groups, including: (1) control(C) + placebo, (2) AT + placebo, (3) S consumption and (4) AT+S consumption. The AT groups performed for eight weeks, three sessions per week and 20-45 minutes per session at an intensity of 60 to 85% of the reserve heart rate, and the S groups of consumed 140 mg / kg of S daily (in two meals).  Serum levels of Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), Cholesterol (CHO), and Triglyceride (TG) were measured before and after the test. Data were analyzed using one-way ANOVA and Bonferroni’s test, and P value less than 0.05 was considered significant.
Results: AT reduced serum levels of LDL, CHO, TG and increased HDL in men with T2D(P ≥ 0.05). Consumption of S reduced LDL, CHO, TG and increased HDL in men with T2D(P ≥ 0.05). AT and S consumption reduced LDL, CHO, TG and increased HDL; also, decrease in LDL, CHO, TG and increase in HDL in the AT and S consumption group was more favorable than the effect of S alone (P ≥ 0.05).
Conclusion: It seems that AT and S consumption simultaneously have interactive effects on reducing LDL, CHO, TG and increasing HDL in men with T2D.

Omid Reza Salehi, Simin Ghabezi, Ali Khajehlandi, Amin Mohammadi,
Volume 8, Issue 2 (7-2020)

Background and objective: Aging and menopause are associated with decreased antioxidant function, however, the role of exercise and estrogen consumption in the health of these people has been shown. The aim of the present study was to investigate the interactive effect of aerobic training (AT) and estrogen (Es) on serum levels of catalase (Cat) and glutathione peroxidase (Gpx) enzymes in ovariectomized rats.
Material and Methods: In this experimental study, 45 ovariectomized rats were randomly divided into 5 groups of 9 rats, including (1) control (C), (2) estrogen solvent (sesame oil) (Sh), (3) AT, (4), Es,and (5) AT+Es. Rats in groups 3 and 5 were trained for eight weeks and three sessions, and groups 4 and 5 randomly received 30 micrograms of estradiol valerate daily for eight weeks. Data analysis was analyzed using one-way analysis of variance and Tukey’s post hoc test at the significance level of 0.05.
Results: Cat levels in the AT (P= 0.006), Es (P= 0.005) and AT + Es (P = 0.001) groups were significantly higher than the control group. Cat levels in the AT + Es group were also significantly higher than in the Es group (P = 0.01). Gpx levels in the AT (P = 0.001), S (P = 0.001) and AT + Es (p = 0.001) groups were significantly higher than the control group, while in the S (P = 0.001) and AT + Es (P = 0.001) groups, they were significantly higher than the AT group.
Conclusion: It seems that aerobic training combined with estrogen consumption synergistically improves the function of the antioxidant system in ovariectomized rats. However, it seems that the signaling pathway of interventions requires further study.

Rasoul Azizi, Amin Mohammadi, Ali Khajehlandi,
Volume 8, Issue 4 (12-2020)

Background and Objective: Although the efficacy of selected training and antioxidant herbs in the treatment of diabetes mellitus has been determined, the interactive effect of selected training and aqueous extract of barberry on insulin resistance and risk factors of type2 diabetes mellitus is not well understood. The aim of the present study was to investigate the effect of aqueous extract of barberry and selected training on some blood factors in men with type2 diabetes.
Material and Methods: In this study, 48 middle-aged men an age range of 40-50 years with type2 diabetes participated in the study. The participants were randomly divided into four groups of 12 subjects, including(1)control, (2)aqueous extract of barberry consumption, (3)aerobic training, and (4)aerobic training+ barberry consumption, based on insulin resistance index. The participants in the aqueous extract of barberry consumption group received200 ml of barberry juice daily for8 weeks and the training and training+ barberry consumption groups performed the training protocol designed in the study for 8 weeks, while the control group did not receive any intervention.
Results: After 8 weeks of exercise training and consumption of aqueous extract of barberry, insulin resistance index, fasting insulin level, fasting blood glucose level, triglyceride level, low density lipoprotein (LDL)and total cholesterol were significantly decreased compared to the control group and high density lipoprotein (HDL)had a significant increase; on the other hand, regarding the intergroup changes, only the levels of LDL and CHO were significant compared to the aqueous extract of barberry consumption and aerobic training.
Conclusion: In general, aqueous extract of barberry consumption and regular exercise training seems to be effective in improving insulin resistance index and blood lipids levels in type2 diabetic patients.

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