Jorjani Biomedicine Journal

Background and Objective: Downscale outcome in assisted reproductive techniques (ART) is associated with lipid peroxidation. Melatonin may have beneficial effects against lipid peroxidation and oxidative stress. This work was aimed to evaluate the ameliorative capacity of melatonin versus the passage of time and lipid peroxidation on sperm parameters from the men with ATS in the ART process.
Material and Methods: Semen samples were collected from 50 asthenoteratozoospermic (ATS) men. Samples were divided into control and melatonin group. The test group were incubated with 6 mM melatonin at 2, 4, 6, and 24 hours. Then total and progressive motility, membrane integrity, and Malondialdehyde levels (MDA) were evaluated. Statistical analysis was carried out by SPSS software (repeated-measures ANOVA).
Results: In the control group, total (p<0.01) and progressive (P<0.05) motility and also, membrane integrity (P<0.03) significantly decreased although, MDA levels of sperm significantly increased (*P<0.04). Moreover, in the melatonin group, the mentioned parameters significantly compensated compared to the control group (P<0.05).
Conclusion: In the outcome, melatonin in vitro treatment paves the way for motility and membrane integrity up-regulating in the ATS men.

Background and Objective: Quercetin is a polyphenolic flavonoid compound with a potent antioxidant impact, proposed to make a drastic contribution in treating male infertility. The current systematic review aimed to provide an overview of previous studies about quercetin's impact on male infertility.
Material and Methods: Electronic search with MeSH words including Quercetin, Infertility, Sperm, Testicular tissue, and Sex hormones was accomplished in databases Web of Science, Scopus, Science Direct, Wiley, NCBI, and Google Scholar. Finally, 296 articles were recognized during the primary search. A total of 144 papers,passing the analysis stage containing Identification, Screening, and Eligibility were selected for assessment.
Results: Quercetin prevents damage to the testicular germinal epithelium and facilitates the spermatogenesis process by strengthening the antioxidant system, reducing lipid peroxidation and oxidative stress, preventing the expression of pro-apoptotic genes, increasing testosterone and gonadotropins.
Conclusion: In conclusion, the present review showed that quercetin by its antioxidant impacts, can counteract various toxins that induce oxidative stress in the male reproductive system.

Background and objectives: Numerous studies have evaluated the effects of silymarin on sperm quality and its neutralization impact of various toxins on the male reproductive system. However, these studies as a whole have not been summarized and categorized yet. Silymarin is a flavonoid and known as a powerful antioxidant compound in the treatment of many diseases including liver disorders, rhinitis, diabetes, and testis disorders. The aim of the study was to discuss the impact of silymarin on the male reproductive system.
Material and Methods: From Apr 1998 to Feb 2020, related articles were extracted from databases of Web of Science (WOS), PubMed, Google Scholar, Science Direct, Scopus, EBSCO and grey literature by seeking MeSH words including Silymarin, Milk thistle, Silybum marianum, testis, Spermatogenesis, and Sex hormones.
Results: Silymarin withholds damage to the testicular germinal epithelium and comforts the spermatogenesis process by amplification the antioxidant system, decrease lipid peroxidation and oxidative stress, preventing the expression of pro-apoptotic genes, increases testosterone and gonadotropins.
Conclusion: In outcome, based on the results, silymarin can boost fertility in sterility males by its talented antioxidant features.