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Showing 5 results for Azarbayjani

Bahareh Yazdanparast Chaharmahali, Mohammad Ali Azarbayjani, Maghsood Peeri, Parvin Farzanegi Arkhazloo,
Volume 6, Issue 4 (12-2018)
Abstract

Background and objectives: Elderly is characterized by decreased cardiac function, which is widely associated with mitochondrial failure in cell death. Elderly causes heart apoptosis. Although the old heart is vulnerable to apoptosis, physical training and some supplements through different mechanisms could be effective in reducing apoptosis. The present study aimed to investigate the effect of interval training on some apoptotic parameters of Bax and Bcl2 cardiomyocytes in old female rats.
 
Methods: In an experimental study, 49 Wistar female rats (2 years old) were randomly assigned into 7 groups: control, saline, curcumin, moderate intensity training, moderate intensity training + curcumin, high intensity training, high intensity training + curcumin. The experimental groups received gavage doses of curcumin 30 mg / kg body weight three days a week via. The saline group also received the same amount of saline. Training groups had moderate and severe exercises on the treadmill for eight weeks, and three sessions per week. Forty-eight hours after the last training session and gavage, the animals were killed and their heart tissues were isolated to determine the levels of Bax and Bcl2.
 
Results: The results indicated that interval training and curcumin consumption could significantly increase the levels of Bcl2 and BAX and the BAX / Bcl2 ratio, the amount of which depends on the intensity of training. Moreover, the combination of training and curcumin had an antagonistic effect.
 
Conclusion: According to the results, physical activity and curcumin separately have a protective effect on the heart tissue; however, these two interventions do not enhance each other’s effect. Hence each one is suggested to be used separately.
 
Faegheh Jafari Amoli, Seyed Ali Hosseini, Mohammad Ali Azarbayjani, Parvin Farzanegi Arkhazloo,
Volume 7, Issue 4 (12-2019)
Abstract

Background and objectives: It has been reported that deep-fried oils (DFOs) used in the preparation of fast foods can affect the immune system. On the other hand, regular physical activity and proper nutrition, in addition to affecting physical function, have a tremendous impact on the immune system. The aim of the present study was to investigate the anti-inflammatory effects of aerobic training (T) and octopamine (O) consumption in the heart tissue of rats fed DFO.
Methods: In this experimental study, 25 male Wistar rats with mean age of 20 weeks old and weighing 300- 350 were purchased and divided into 5 groups of 5 rats, including: 1) control, 2) DFO, 3) DFO+T, 4) DFO+O and 5) DFO+T+O. During four weeks, groups 2- 5 received DFO by gavage; groups 3- 5 ran on treadmill (with speed of 50% Vo2max in the first week which reached 65% Vo2max in the last week) five sessions per week and 20 minutes per session and groups 4-5 received 81 μmol/kg octopamine supplement peritoneally for 5 days per week. Nuclear factor kappa B (NF-κB) and tumor necrosis factor-alpha (TNF-α) gene expression were measured in heart tissue.
Results: DFO significantly increased NF-κB (P=0.005) and TNF-α (P=0.001) gene expression levels; T significantly on decreased NF-κB (P=0.01) and TNF-α (P=0.007) gene expression levels; O consumption significantly decreased NF-κB (P=0.001) and TNF-α (P=0.001) gene expression levels; however, the interactive effects of T and O consumption on NF-κB (P=0.57) and TNF-α (P=0.20) gene expression levels was not significant.
Conclusion: It seems that T and O consumption alone have anti-inflammatory effects on the heart tissue of rats fed DFO, however T and O do not have anti-inflammatory interactive effects.
Mohammad Mousaei, Mohammad Ali Azarbayjani, Maghsoud Peeri, Seyed Ali Hosseini,
Volume 7, Issue 4 (12-2019)
Abstract

Background and objectives: Controlling nutrition and exercise can be two important strategies in controlling tendon health. It has been reported that resistance training and palm pollen separately can improve Scleraxis (Scx) in tendon tissue; so present study aimed to investigate the interactive effects of resistance training with ethanolic extract of palm pollen on Scx protein and gene expression levels in the tendon tissue of male adult rats.
Methods: In this experimental study 30 male adult rats divided into 6 groups of 6 rats including: 1) sham, 2) training, 3) palm pollen, 4) testosterone, 5) training + palm pollen, and 6) training + testosterone. During 4 weeks, groups 2, 5, and 6 performed resistance trainings for five sessions per week; groups 3 and 5 received 100 mg/kg palm pollen for five days per week via gavage and groups 4 and 6 received 2 mg/kg testosterone propionate peritoneally. Scx protein and gene expression levels were measured in tendon tissue by Western blot and real-time PCR methods respectively. Shapiro- Wilk, one way ANOVA with Tukey’s post- hoc tests were used to analyze the findings (P≤0.05).
Results: Training significantly increased Scx protein levels (P=0.005); palm pollen significantly increased Scx gene expression levels (P=0.001); training + palm pollen significantly increased Scx protein and gene expression levels (P=0.001) also training + palm pollen had more favorable effect on increase of Scx protein and gene expression levels compared to training and palm pollen alone (P=0.001).
Conclusion: It seems that resistance training simultaneously with palm pollen administration can have a more favorable effect than each one alone on improving Scx protein and gene expression levels in tendon tissue of male adult rats.
Abdol Kheder Keshtvarz, Maghsoud Peeri, Mohammad Ali Azarbayjani, Seyed Ali Hosseini,
Volume 7, Issue 4 (12-2019)
Abstract

Background and objective: Exercise and nutrition are two factors influencing the improvement of inflammatory markers in patients with colon cancer. Aim of present study was to investigate the effect of aerobic training (AT) with Purslane (Portulaca Oleracea) Seed (PS) on toll like receptor 2 (TLR-2) and TLR-4 in colon tumor tissue of rats with colon cancer.
Methods: In this experimental study 30 adults rats were divided into five groups of six rats including: 1) healthy control, 2) control, 3) training, 4) PS, and 5) training + PS. Colon cancer induced by intra-peritoneal injection of azoxymethane in groups 2- 5. During eight weeks, groups 3 and 5 performed AT for five sessions per week also groups 4 and 5 received 75 mg/kg PS intra-peritoneally. TLR2 and TLR4 protein levels were measured by ELISA method. For review the normal distribution and data Shapiro- wilk was used and for statistical analysis of data one way ANOVA with Tukey’s post- hoc tests were used (P≤0.05).
Results: Training had not significant effect on TLR-2 (P=0.91) and TLR-4 (P=0.95); PS and training + PS significantly decreased TLR-2 and TLR-4 (P=0.001) also training + PS had more favorable effect on decrease of TLR-2 compare to training and PS alone (P=0.001).
Conclusion: Although PS alone can improve TLR-2 and TLR-4 levels in colon tumor tissue of adult rats with colon cancer, nevertheless it appears that AT along with PS have more favorable effects on improvement of TLR-2 compare to training and PS alone.

Somaye Pouranfar, Mohammad Ali Azarbayjani, Bahram Abedi,
Volume 8, Issue 4 (12-2020)
Abstract

Background and Objective: Reports indicate that over 60% of people with diabetes die from cardiovascular diseases. The present study was conducted to investigate the interactive effects of resistance training and genistein consumption on the serum levels of vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1) and C-Reactive Protein (CRP) in diabetic rats with streptozotocin.
Material And Methods: In this experimental study, 40 diabetic rats were selected and divided into 5 groups of 8 subjects, including: (1) control, (2) sham (dimethyl sulfoxide), (3) resistance training (4), genistein consumption, and (5) resistance training and genistein consumption. Rats in groups 3 and 5 received 8 weeks of resistance training, 3 sessions per week, with 30 to 100% body weight, and rats in groups 4 and 5 received 30 mg/kg of peritoneal genistein per day. Data were analyzed using independent sample t-test and two-way ANOVA in SPSS software (p≤0.05).
Results: Genistein consumption has a significant effect on reduced serum levels of VCAM and ICAM in diabetic rats (p≤0.05). Eight weeks of resistance training has a significant effect on reduced serum levels of ICAM and CRP in diabetic rats (p≤0.05). Resistance training and genistein consumption have interactive effects on reduced serum levels of VCAM and CRP in diabetic rats (p≤0.05).
Conclusion: Resistance training and genistein consumption simultaneously appear to reduce the risk of atherosclerosis in diabetic rats.


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