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Ali Ahmadi , Neda Soleimani, Parham Abedini ,
Volume 6, Issue 4 (12-2018)

Background and objectives: Bacterial antibiotic resistance is a major issue in the process of infectious disease treatments. The aim of this study was an evaluation of the antibacterial activity of Punica granatum flower extract against several gram-negative and positive clinical bacterial isolates.
Methods: An adequate dried flower of an endemic mature Punica granatum plant was used for extraction. The standard strain of several gram negative and positive bacteria was chosen for this study, as well as some distinguished clinical strains such as Pseudomonas aeruginosa and Enterococcus spp. In order to indicate the antibacterial effect of Punica granatum mature flower, well-diffusion method was done for each bacterium of the extraction of the flower, so that zone inhibitions can be reported. MIC and MBC test was done.
Results: Disc diffusion test was done and the greatest zone inhibition Shigella was 39 mm and then Salmonella typhimurium 13.1 mm. The lowest antibacterial effect of P. granatum extraction was gained on Proteus with 6 mm of zone inhibition. The Highest MIC and MBC effect was obtained from antibacterial evaluation on S. typhimurium and S. epidermidis.
Conclusion: the antibacterial activities of medicinal plants, pharmaceutical companies are just using medicinal plants in association with synthetic drugs in order to obtain better results. Setting up a more analytic test on medicinal plants same as HPLC test could be the next stage of this study in order to reach to a higher reliance of medicinal plants antibacterial activities qualification So That we could combine them with synthetic drugs and improve their efficiency.
Fatemeh Monirian, Reyhane Abedi, Negar Balmeh, Samira Mahmoudi, Fereshteh Mirzaei Poor,
Volume 8, Issue 3 (10-2020)

Background and objective: Some common problems in the health care system are Microbial resistance to antibiotics, the side effects of food additives, and preservatives. Considering the antibiotic resistance of microorganisms and the need to identify new compounds, the present study was conducted to determine the antimicrobial effects of Artemisia extracts.
Material And Method The study was performed in two stages including extraction and determination of antibacterial properties of aqueous, ethanolic, methanolic, acetone/ethanolic, and hydroethanolic extracts of Artemisia on standard Pseudomonas aeruginosa, Streptococcus pyogenes, and oral bacteria sample. The well diffusion method was performed to evaluate the concentration that had an inhibitory and bactericidal effect.
Result: Aqueous extract had an effect on the oral bacteria sample (8 mm), the methanolic extract had an effect on S. pyogenes and oral bacteria sample (15 mm) and finally acetone/ethanolic extracts had antimicrobial properties against S. pyogenes (16 mm). The concentration used for all five extracts was 50 mg/ml and showed an inhibition effect on the growth of S. pyogenes standard strain and oral bacteria sample. The less serial dilutions of extracts were tested but no antibacterial effects were seen. So, 50 mg/ml was the minimum concentration that had an inhibitory and bactericidal effect.
Conclusion: It can be inferred that aqueous, methanolic, and acetone/ethanolic extracts of Artemisia had the highest inhibitory effect on S. pyogenes and the oral bacteria sample. Consequently, by applying different extraction methods and by utilizing different solvents, it may be possible to more efficiently obtain biomaterials with antimicrobial properties from this plant.

Somaye Pouranfar, Mohammad Ali Azarbayjani, Bahram Abedi,
Volume 8, Issue 4 (12-2020)

Background and Objective: Reports indicate that over 60% of people with diabetes die from cardiovascular diseases. The present study was conducted to investigate the interactive effects of resistance training and genistein consumption on the serum levels of vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1) and C-Reactive Protein (CRP) in diabetic rats with streptozotocin.
Material And Methods: In this experimental study, 40 diabetic rats were selected and divided into 5 groups of 8 subjects, including: (1) control, (2) sham (dimethyl sulfoxide), (3) resistance training (4), genistein consumption, and (5) resistance training and genistein consumption. Rats in groups 3 and 5 received 8 weeks of resistance training, 3 sessions per week, with 30 to 100% body weight, and rats in groups 4 and 5 received 30 mg/kg of peritoneal genistein per day. Data were analyzed using independent sample t-test and two-way ANOVA in SPSS software (p≤0.05).
Results: Genistein consumption has a significant effect on reduced serum levels of VCAM and ICAM in diabetic rats (p≤0.05). Eight weeks of resistance training has a significant effect on reduced serum levels of ICAM and CRP in diabetic rats (p≤0.05). Resistance training and genistein consumption have interactive effects on reduced serum levels of VCAM and CRP in diabetic rats (p≤0.05).
Conclusion: Resistance training and genistein consumption simultaneously appear to reduce the risk of atherosclerosis in diabetic rats.

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