Volume 6, Issue 1 (3-2018)  

View This Issue in Alternative Language Export Journal XML Articles RSS
Abstract (3239 Views) | Full-Text (PDF) (999 Downloads)   |   Graphical Abstract   |   Highlights

  • It has been suggested that various epigenetic deviations play a major role in the pathogenesis of endometriosis.
  • Steroidogenic factor 1 (SF-1; NR5A1) is an essential transcription factor for estrogen biosynthesis in endometrial cells.
  • Here, we aimed to compare the methylation status of the SF-1 gene promoter region in women with endometriosis in comparison to healthy subjects.
  • The methylation status of SF-1 gene promoter was decreased significantly in endometriosis samples.  
  • SF-1 gene promoter hypomethylation could increase the relative expression of SF-1 gene in endometriosis which may lead to the development or progression of the disease.



Export as: HTML | XML | RSS

© 2021 CC BY-NC 4.0 | Jorjani Biomedicine Journal

Designed & Developed by : Yektaweb