دوره 9، شماره 1 - ( 1-1400 )                   جلد 9 شماره 1 صفحات 44-54 | برگشت به فهرست نسخه ها

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Sohrabi G, Malmir M, Ghafarizade A A, Faraji T. Ameliorative Effect of Melatonin Versus the Passage of Time and Lipid Peroxidation on Sperm Motility in Asthenotratospermic Men. Jorjani Biomed J. 2021; 9 (1) :44-54
URL: http://goums.ac.ir/jorjanijournal/article-1-791-fa.html
Ameliorative Effect of Melatonin Versus the Passage of Time and Lipid Peroxidation on Sperm Motility in Asthenotratospermic Men. فصلنامه علمی پژوهشی زیست پزشکی جرجانی. 1400; 9 (1) :44-54

URL: http://goums.ac.ir/jorjanijournal/article-1-791-fa.html


چکیده:   (596 مشاهده)
Background and Objective: Downscale outcome in assisted reproductive techniques (ART) is associated with lipid peroxidation. Melatonin may have beneficial effects against lipid peroxidation and oxidative stress. This work was aimed to evaluate the ameliorative capacity of melatonin versus the passage of time and lipid peroxidation on sperm parameters from the men with ATS in the ART process.
Material and Methods: Semen samples were collected from 50 asthenoteratozoospermic (ATS) men. Samples were divided into control and melatonin group. The test group were incubated with 6 mM melatonin at 2, 4, 6, and 24 hours. Then total and progressive motility, membrane integrity, and Malondialdehyde levels (MDA) were evaluated. Statistical analysis was carried out by SPSS software (repeated-measures ANOVA).
Results: In the control group, total (p<0.01) and progressive (P<0.05) motility and also, membrane integrity (P<0.03) significantly decreased although, MDA levels of sperm significantly increased (*P<0.04). Moreover, in the melatonin group, the mentioned parameters significantly compensated compared to the control group (P<0.05).
Conclusion: In the outcome, melatonin in vitro treatment paves the way for motility and membrane integrity up-regulating in the ATS men.
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نوع مقاله: تحقیقی | موضوع مقاله: علوم پایه پزشکی
دریافت: 1399/11/7 | پذیرش: 1399/12/12 | انتشار: 1400/1/10

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