Concentration of soluble form of hepatocyte growth factor receptor in cerebrospinal fluid and serum of patients with bacterial and viral meningitis

Khoshdel Rad N,; Mashayekhi F,; Mirzajani E,

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Khoshdel Rad N, Mashayekhi F, Mirzajani E. Concentration of soluble form of hepatocyte growth factor receptor in cerebrospinal fluid and serum of patients with bacterial and viral meningitis. mljgoums 2012; 6 (1) :1-6
URL: http://mlj.goums.ac.ir/article-1-193-en.html

Concentration of soluble form of hepatocyte growth factor receptor in cerebrospinal fluid and serum of patients with bacterial and viral meningitis

Khoshdel Rad N¹

, Mashayekhi F

², Mirzajani E³

1- Master student, Department of Biology,
2- Associate Professor Department of Biology, , mashayekhi@guilan.ac.ir
3- Assistant Professor of Cellular and Molecular Research Center

Abstract: (18497 Views)

Abstract Background and objectives: C-Met is a proto-oncogene that encodes a protein known as hepatocyte growth factor receptor (HGFR). The HGF receptor possesses tyrosine -kinase activity and it is essential for embryonic development, wound healing and cancer. Many proteins are proteolytically released from the surface by a process known as ectodomain shedding. Shedding occurs under normal physiologic conditions and can be increased in certain pathologies. C-Met can be seen among many receptors for which ectodomain shedding has been shown. The aim of this study was to determine the concentration of soluble c-Met in the cerebrospinal fluid (CSF) and serum samples of patients with viral and bacterial meningitis. Material and Methods: in this study, 75 CSF and serum samples of patients with bacterial meningitis, 71 with viral meningitis and 82 normal controls were investigated. The soluble c-Met concentration was determined by enzyme linked immunosorbent assay (ELISA). Result: the amount of soluble c-met in CSF of patients with bacterial meningitis ( 83.91±5.50), viral meningitis ( 80.41±4.71) and control group ( 22.66±3.39) are compared with that in serum of patients with bacterial meningitis ( 561.58±25.87), viral meningitis ( 550.50 ±34.34) and control group ( 256.25±18.55). There is significant increase in the CSF and serum’s soluble c-Met expression in the patients with meningitis, in comparison with control group. Conclusion: The data presented here indicate that soluble c-Met is a constant component of human serum and CSF, but it can not be used for differentiating bacterial meningitis from viral meningitis. Key words: Soluble c-Met, concentration, cerebrospinal fluid, serum, meningitis

Keywords: Soluble c-Met, concentration, cerebrospinal fluid, serum, meningitis

Full-Text [PDF 187 kb] [English Abstract] (3659 Downloads)

Research Article: Original Paper |
Received: 2012/08/1 | Accepted: 2014/01/12 | Published: 2014/01/12 | ePublished: 2014/01/12