Jorjani Biomedicine Journal
فصلنامه علمی پژوهشی زیست پزشکی جرجانی
Jorjani Biomed J
Medical Sciences
http://goums.ac.ir/jorjanijournal
1
admin
2645-3509
10.52547/jorjanibiomedj
en
jalali
1401
2
1
gregorian
2022
5
1
10
2
online
1
fulltext
en
The Effect of Exercise and Folate Nano-Liposomes on D1 and D2 Receptor Gene Expression in the Brain of Alzheimer's Rats
پزشکی عمومى
General medicine
تحقیقی
Original article
<div style="text-align: justify;"><strong>Background</strong>: Alzheimer's is a neurodegenerative disorder characterized by memory loss and cognitive dysfunction. Research has shown that blood metal levels and physical activity may be key to injury and possibly Alzheimer's treatment. The aim of this study was to investigate the effects of high intensity interval training (HIIT) and Folate Nano-liposome on the expression of D1 and D2 receptors in the hippocampal tissue of Alzheimer's rats.<span dir="RTL"></span><br>
<strong>Methods</strong>: Thirty<span dir="RTL">-</span>three male Wistar rats at the age of eight weeks were prepared from Pasteur Institute. Rats were randomly divided into 5 groups (healthy control, Alzheimer's control, Alzheimer+ HIIT, Alzheimer +Folate Nano liposomes, Alzheimer+ HIIT +Folate Nano liposomes).Alzheimer's induction was performed and Folate Nano-liposomes were injected as a supplement .After the last training session, rats were anesthetized and the hippocampus was analyzed.<br>
<strong>Results</strong>: The results of one-way ANOVA showed a significant increase between the groups in D1 mRNA and D2 mRNA (P≤0.000). The results of the Bonferroni post hoc test showed that there was a significant increase the control group and the Alzheimer's, Alzheimer's + HIIT and Alzheimer's +folate Nano liposomes. There was a significant increase between Alzheimer's group and Alzheimer's+ HIIT and Alzheimer's+ HIIT+ folate Nano-liposomes (P≤0.05).<br>
<strong>Conclusion</strong>: Resistance training and Folate Nano-liposomes have changed the content of D1 and D2 in the brain after Alzheimer's induction. These changes may be due in part to the synergistic effect of physical activity and Nano-pharmaceuticals in preventing or reducing the detrimental effects of pathological conditions. <span dir="RTL"></span></div>
Exercise,Receptors Dopamine,Dietary Supplements,Immune System,
36
44
http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-787-5&slc_lang=en&sid=1
farah
nameni
nameni@iauvaramin.ac.ir
10031947532846007923
10031947532846007923
Yes
Department of Sport Physiology, Varamin Pishva Branch, Islamic Azad University
Fateme
Firoozmand
mefiroozmand@gmail.com
10031947532846007924
10031947532846007924
No
MSc. of Sport Physiology, Varamin Pishva Branch, Islamic Azad University