Jorjani Biomedicine Journal
فصلنامه علمی پژوهشی زیست پزشکی جرجانی
Jorjani Biomed J
Medical Sciences
http://goums.ac.ir/jorjanijournal
1
admin
2645-3509
10.52547/jorjanibiomedj
en
jalali
1399
12
1
gregorian
2021
3
1
9
1
online
1
fulltext
en
Ameliorative Effect of Melatonin Versus the Passage of Time and Lipid Peroxidation on Sperm Motility in Asthenotratospermic Men
علوم پایه پزشکی
Basic Medical Sciences
تحقیقی
Original article
<div style="text-align: justify;"><strong><em>Background and Objective</em></strong><strong>:</strong> Downscale outcome in assisted reproductive techniques (ART) is associated with lipid peroxidation. Melatonin may have beneficial effects against lipid peroxidation and oxidative stress. This work was aimed to evaluate the ameliorative capacity of melatonin versus the passage of time and lipid peroxidation on sperm parameters from the men with ATS in the ART process.<br>
<strong><em>Material and Methods:</em></strong> Semen samples were collected from 50 asthenoteratozoospermic (ATS) men. Samples were divided into control and melatonin group. The test group were incubated with 6 mM melatonin at 2, 4, 6, and 24 hours. Then total and progressive motility, membrane integrity, and Malondialdehyde levels (MDA) were evaluated. Statistical analysis was carried out by SPSS software (repeated-measures ANOVA).<br>
<strong><em>Results:</em></strong> In the control group, total (p<0.01) and progressive (P<0.05) motility and also, membrane integrity (P<0.03) significantly decreased although, MDA levels of sperm significantly increased (*P<0.04). Moreover, in the melatonin group, the mentioned parameters significantly compensated compared to the control group (P<0.05).<br>
<strong><em>Conclusion:</em></strong> In the outcome, melatonin in vitro treatment paves the way for motility and membrane integrity up-regulating in the ATS men.</div>
Melatonin,lipid peroxidation,asthenospermia and teratozoospermia,membrane integrity,ART
44
54
http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-794-1&slc_lang=en&sid=1
Ghadir
Sohrabi
iausohrabi1978@gmail.com
10031947532846006486
0000000321427794
No
Tabriz University of Medical Sciences International Branch Aras
Mahdi
Malmir
m.malmir66@hotmail.com
10031947532846006487
000000017915849X
No
Department of Midwifery, Tuyserkan Branch, Islamic Azad University, Tuyserkan, Iran
Ali Asghar
Ghafarizade
Ghafarizade@acecr.ac.ir
10031947532846006488
0000000309586303
Yes
Academic Center for Education, Culture and Research, Arak, Iran
Tayebeh
Faraji
faraji.tb@hotmail.com
10031947532846006489
0000000248772179
No
Academic Center for Education, Culture and Research, Arak, Iran