Jorjani Biomedicine Journal
فصلنامه علمی پژوهشی زیست پزشکی جرجانی
Jorjani Biomed J
Medical Sciences
http://goums.ac.ir/jorjanijournal
1
admin
2645-3509
10.52547/jorjanibiomedj
en
jalali
1398
6
1
gregorian
2019
9
1
7
3
online
1
fulltext
fa
Association of Interferon-gamma Gene Polymorphism (+874 A/T) and Oral Lichen planus susceptibility: Systematic Review and Meta-Analysis
پزشکی عمومى
General medicine
تحقیقی
Original article
<div style="text-align: justify;"><strong><em>Background and objectives</em></strong><strong><em>:</em></strong> Most studies have identified interferon-gamma (IFN-γ) as a key role in the pathogenesis of oral lichen planus (OLP). Recent studies have also shown a link between IFN-γ (+874 A/T) gene polymorphism and OLP. The purpose of the present meta-analysis is to investigate the relationship between IFN-γ (+874 A/T) gene polymorphism and susceptibility to OLP.<span dir="RTL"></span><br>
<strong><em>Methods:</em></strong> A systematic search of resources to investigate the association between IFN-γ and OLP from Google scholar, PubMed, Embase, Cochrane, Scopus, Proquest, Ovid and Web of science (from 2000 to April 2019) completed. Two individuals independently assessed the quality of the articles. Endnote X5 resource management software was used to organize, study titles and abstracts as well as identify duplicates. A random effect model was also used to perform the meta-analysis.<br>
<strong><em>Results:</em></strong> Four IFN-γ (+874 A/T) polymorphism studies with 297 patients in the case group and 621 healthy controls in the 4 different countries were included. After meta-analysis, a significant association was found between IFN-γ polymorphism (+874 A/T) and OLP. (T vs A: odds ratio (OR) = 1.62; 95% CI = 1.28-2.04; TT vs AA: OR = 2.67; 95% CI = 1.6- 4.45; AT vs AA: OR = 1.56; 95% CI = 1.6- 4.45; TT vs AT + AA: OR = 1.73; 95% CI = 1.13-2.64; AT + TT vs AA: OR = 1.75; 95% CI = 1.28-2.43)<br>
<strong><em>Conclusion:</em> </strong>Based on this meta-analysis, there was a positive relationship between IFN-γ (+874 A/T) gene polymorphism and the risk of OLP. The findings showed that increasing TT genotypes significantly increased susceptibility to OLP in comparison with other genotypes.</div>
oral lichen planus, gene polymorphism, IFN-γ
45
55
http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-558-2&slc_lang=fa&sid=1
paria
motahari
paria@motahari.com
10031947532846005910
10031947532846005910
Yes
Department of Oral Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Fatemeh
Pournaghi Azar
10031947532846005911
10031947532846005911
No
Research center for evidence based medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Parisa
Rasouly
10031947532846005912
10031947532846005912
No
Department of Oral Medicine, Tabriz University of Medical Sciences, Tabriz, Iran