en بهداشت Health تحقیقی Original article <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> Research has shown that high-intensity interval training (HIIT) is a convenient and time-efficient approach that promotes oxidative capacity. Therefore, this study aimed to investigate the effect of HIIT on the gene expression of some inflammatory and anti-inflammatory markers of hippocampal tissue in aged male Wistar rats.<br> <b>Methods:</b> In this experimental study, 21 male Wistar rats were divided into three equal groups: 1- control (C), 2- elderly control (EC), and 3- elderly training (ET). After two weeks of adaptation to the laboratory environment, six weeks of HIIT were performed for the training group. Forty-eight hours after the last training session, hippocampal tissue was isolated to examine the mean levels of interleukin-10 (IL-10), IL-6, and IL-1&beta; gene expression. One-way analysis of variance and Tukey&#39;s post-hoc test with a significance level of 0.05 were used to analyze the data.<br> <b>Results:</b> There was a significant increase in the expression of IL-6 and IL-1&beta;, while a significant decrease in IL-10 expression (p=0.001) in the C group compared to the EC. After six weeks of HIIT, expression of IL-6 (p=0.001) and IL-1&beta; (p=0.001) significantly decreased, whereas IL-10 expression significantly increased (p=0.001) in the ET group compared to the EC group.<br> <b>Conclusion</b>: It seems that HIIT activity has beneficial effects on preventing the process of neural degeneration. Moreover, it is promising as a non-pharmacological strategy for controlling complications resulting from the aging process due to its anti-inflammatory properties.</span></span></div> High-Intensity Interval Training, Inflammation, Hippocampus, Aging 37 43 http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-1050-1&slc_lang=en&sid=1 Sara Ghasdi sara.ghasd79@gmail.com 100319475328460010567 0009-0005-1654-9668 No Department of Sport Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran Mohammad Rami m.rami@scu.ac.ir 100319475328460010568 100319475328460010568 Yes Department of Sport Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran Abdolhamid Habibi hamidhabibi330@gmail.com 100319475328460010569 100319475328460010569 No Department of Sport Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran