Jorjani Biomedicine Journal

en Aerobic exercise and resveratrol cooperatively modulate hippocampal mitochondrial mitophagy in Alzheimer’s disease rat models بهداشت Health تحقیقی Original article <div style="text-align: justify;">Background: Mitochondrial proteostasis disruption in Alzheimer’s disease (AD) results in impaired mitochondrial autophagy (mitophagy). This study evaluated the effects of 8-week aerobic exercise training (T), resveratrol (RSV) supplementation, and their combination on mitophagy markers in an AD rat model. Methods: In this experimental study, 35 male Wistar rats were divided into five groups: Control (NO), Alzheimer’s (AD), Alzheimer’s-Training (ADT), Alzheimer’s-Resveratrol (ADRSV), and Alzheimer’s-Training-Resveratrol (ADTRSV). RSV groups received 20 mg/kg/day orally. The aerobic exercise protocol consisted of treadmill running (6–18 m/min) five days per week for eight weeks. Hippocampal PINK1 and PARKIN expression levels were analyzed. Results: AD induction significantly reduced PINK1 and PARKIN expression (P < 0.001). Compared to the AD group, significant increases in PINK1 and PARKIN were observed in the ADT (P = 0.043; P = 0.005), ADRSV (P = 0.033; P = 0.046), and ADTRSV (P < 0.001) groups. The ADTRSV group showed higher PINK1 expression than ADT (P = 0.036) and ADRSV (P = 0.046), and greater PARKIN expression than ADRSV (P = 0.046). Conclusion: Exercise training and RSV supplementation improved hippocampal mitophagy in AD rats, with synergistic effects observed in the combined intervention. These findings suggest that non-pharmacological strategies may mitigate AD-related mitochondrial dysfunction.</div> Exercise Therapy, Resveratrol, Mitophagy, Hippocampus, Alzheimer Disease 25 30 http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-1039-1&slc_lang=en&sid=1 Elham Heydarzadeh Elham.heidarzadeh@iau.ac.ir 100319475328460010514 100319475328460010514 No Department of Physical Education, Sa.C., Islamic Azad University, Sanandaj, Iran Kamal Azizbeigi kazizbeigi@iau.ac.ir 100319475328460010515 100319475328460010515 Yes Department of Physical Education, Sa.C., Islamic Azad University, Sanandaj, Iran Khalid Mohamadzadeh Salamat kh.mohamadzadeh@iau.ac.ir 100319475328460010516 100319475328460010516 No Department of Physical Education, Sa.C., Islamic Azad University, Sanandaj, Iran