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, , ,
Volume 1, Issue 1 (5-2013)
Abstract

Scleroderma is a connective tissue disorder identified with skin thickening and fibrosis together with inflammatory, vascular, and internal organ changes. The prevalence of this condition is three times higher in women than in men. Pregnancy was known to threaten maternal and fetal health in patients with scleroderma. Today, however, the patients have the chance of a successful pregnancy through careful and appropriate planning, monitoring, and treatment methods. Nevertheless, in order to prevent pregnancy complications in patients with scleroderma, pregnancy has to be planned during the stable phase of the disease and not during its rapid progression course. In this article we reported a pregnancy out come in a woman with scleroderma and polymyositis and explained its emergent procedures and treatment.


Milad Ahmad-Aghdami , Saeed Mohammadi ,
Volume 13, Issue 1 (3-2025)
Abstract

Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by heterogeneous clinical manifestations and the production of autoantibodies, making early diagnosis challenging. Traditional diagnostic methods lack sensitivity and specificity, leading to delayed intervention and irreversible organ damage. Single-cell technologies offer a novel opportunity to investigate the cellular landscape of SLE at the level of individual cells. By profiling the gene expression, protein expression, and functional states of thousands of individual cells simultaneously, these technologies can reveal critical findings such as the expansion of type I interferon-producing pDCs and dysregulated T/B cell subsets involved in SLE pathogenesis. This editorial highlights the transformative potential of single-cell analysis in identifying disease-relevant cell populations and their functional states, ultimately paving the way for earlier diagnosis, personalized treatment, and improved outcomes for patients with SLE.


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