Search published articles


Showing 5 results for Curcumin
Curcumin (Extracted from Tumeric) and its Therapeutic Effects
Arezou Khosrojerdi, Kazem Mashayekhi, Hadi Zare Marzouni,
Volume 4, Issue 2 (10-2016)
Abstract

Background and Objectives:  The application of herbal medicine has been rising in recent years. Therefore, it is logical to revise and revive these traditional drugs while identifying their mechanisms of action can result in developing new treatments for many diseases. Curcumin is the most important component of Turmeric with numerous therapeutic properties. We aimed to review the anti-inflammatory and anti-microbial properties of Curcumin and introduce it as a therapeutic molecule in the present article.

Methods: In this review, 121 articles were selected from authenticated electronic resources and scientific library databases such as Pubmed, Medline, Sciencedirect, WOS, DOAJ, SID, Iranmedex, Magiran and Google Scholar search engine in which Curcumin (Turmeric) had been evaluated as a therapeutic molecule from differeny aspects.

Results: Our findings from the literature revealed that immune responses against infectious and inflammatory factors could be fascilitated by Curcumin. However, the low solubility in water and minimal bioavailability which may lead to poor absorbance from gastrointestinal tract, quick metabolization and elimination from blood circulation are the most important problems during oral consumption.

Conclusion: According to the results of the present review article, Curcumin possesses efficient anti-inflammatory, anti-microbial, anti-viral and anti-parasitic properties. However, the low bioavailability of this substance has limited its treatment properties. Nowadays, several mechanisms have been proposed to increase the bioavailability which can improve its absorption.


Increased Expression of Bax and Bcl2 Apoptosis Biomarkers in the Heart of Old Female Rats After Interval Training and Curcumin Consumption
Bahareh Yazdanparast Chaharmahali, Mohammad Ali Azarbayjani, Maghsood Peeri, Parvin Farzanegi Arkhazloo,
Volume 6, Issue 4 (12-2018)
Abstract
Background and objectives: Elderly is characterized by decreased cardiac function, which is widely associated with mitochondrial failure in cell death. Elderly causes heart apoptosis. Although the old heart is vulnerable to apoptosis, physical training and some supplements through different mechanisms could be effective in reducing apoptosis. The present study aimed to investigate the effect of interval training on some apoptotic parameters of Bax and Bcl2 cardiomyocytes in old female rats.
 
Methods: In an experimental study, 49 Wistar female rats (2 years old) were randomly assigned into 7 groups: control, saline, curcumin, moderate intensity training, moderate intensity training + curcumin, high intensity training, high intensity training + curcumin. The experimental groups received gavage doses of curcumin 30 mg / kg body weight three days a week via. The saline group also received the same amount of saline. Training groups had moderate and severe exercises on the treadmill for eight weeks, and three sessions per week. Forty-eight hours after the last training session and gavage, the animals were killed and their heart tissues were isolated to determine the levels of Bax and Bcl2.
 
Results: The results indicated that interval training and curcumin consumption could significantly increase the levels of Bcl2 and BAX and the BAX / Bcl2 ratio, the amount of which depends on the intensity of training. Moreover, the combination of training and curcumin had an antagonistic effect.
 
Conclusion: According to the results, physical activity and curcumin separately have a protective effect on the heart tissue; however, these two interventions do not enhance each other’s effect. Hence each one is suggested to be used separately.
 
Study the Effect of Swimming Training and Curcumin on Reduction of BAX and P53 proteins and Increase in BCL2 protein in Heart Tissue of Rats During Withdrawal of Excessive Ethanol Consumption
Mona Abdolhamid Tehrani,
Volume 10, Issue 4 (12-2022)
Abstract
Background and objectives: Epidemiological studies have shown that high dose of ethanol can lead to apoptosis. On the other hand, the consumption of medicinal plants such as turmeric in the diet and performing physical activities are considered as factors to control apoptosis. Therefore, this article aims to mainly evaluate the anti-apoptotic effects of swimming and curcumin interactively during withdrawal of binge ethanol exposure in heart tissues.
Material and Methods: In this study, 40 rats were received ethanol (25% W/V) as gavage for four days every eight hours. Then, 7 days after ethanol withdrawal, they were classified in 5 groups, including: (1) control, (2) curcumin, (3) swimming, (4) swimming with curcumin, and (5) sham. Groups 3 and 4 performed swimming five sessions a week for two weeks, and groups 2 and 4 received 50 mg/kg of curcumin five times a week for two weeks. The amount of BAX, BCL2, and P53 protein and BCL2/BAX ratio were measured using western blot technique. The data were tested using the independent t-test at a significant level (p≥0.05) and two-way ANOVA.
Results: Swimming had a significant effect on reduction of p53 (F=60.051, P<0.0001, η2=0.741), Bax (F=62.594, P<0.0001, η2=0.887) and Bax/Bcl-2 ratio (F=290.591, P<0.0001, η2=0.973), and increase of Bcl-2 (F=150.940, P<0.0001, η2=0.950); Curcumin had a significant effect on decrease of p53 (F=5.513, P=0.029, η2=0.208), Bax (F=66.146, P<0.0001, η2=0.892) and Bax/Bcl-2 ratio (F=260.655, P<0.0001, η2=0.970), and increase of Bcl-2 (F=73.274, P<0.0001, η2=0.902). The results from two-way ANOVA showed the interactive effect of exercise and curcumin on the decrease of BAX (F=35.847, P<0.0001, η2=0.818) and BAX/BCL-2 ratio (F=175.887, P<0.0001, η2=0.956), and the increase of BCL-2 (F=21.205, P=0.002, η2=0.726) were significant; but it had no significant effect on p53 (F=0.000, P=0.999, η2=0.000).
Conclusion: Swimming and curcumin consumption simultaneously can significantly moderate apoptosis caused by ethanol in the heart tissue.

Aerobic Training and Curcumin can Improve Adiponectin Gene Expression in Adipose Tissue and Body Mass Index of Rats Fed with High-Fat Diet
Zahra Hashemi Shiri, Tahereh Bagherpour, Nemtallah Nemati,
Volume 10, Issue 4 (12-2022)
Abstract
Background: Obesity has been recognized as a global problem that is increasing day by day. Although t Background: Obesity has been recognized as a global problem that is increasing day by day. Although the favorable effects of training and herbal supplements have been reported in this regard, the synergistic effects of the two are still a challenge for researchers. The purpose of this study was to investigate the effect of six weeks of Aerobic Training (AT) and Curcumin (Cu) consumption on adiponectin gene expression in the visceral adipose tissue and some anthropometric indicators of rats fed with High-Fat Diet (HFD).
Material and Methods: In this experimental study, 40 rats with HFD (1.5 mg/kg/day high-fat emulsion) were randomly divided into five groups, including: (1) Healthy Control (HC), (2) High-Fat Diet Control (HFD), (3) HFD+Cu, (4) HFD+AT, and (5) HFD+Cu+AT. Aerobic training was carried out for six weeks, five sessions per week and each session of training was performed 10-50 minutes at a speed of 25-30 meters per minute and a slope of 15 degrees. Also, curcumin was fed to rats by gavage in the amount of 1.5 mg/kg/day. One-way analysis of variance with Tukey's post hoc test was used to analyze adiponectin and ANCOVA test with Bonferroni's test was used to analyze BMI. Data were analyzed in Prism GraphPad PRISM 3.8.3 software (P≤0.05).
Results: Adiponectin gene expression levels in the HFD+AT, HFD+Cu and HFD+AT+Cu groups were significantly higher than the HFD group (P≥0.05). Weight and BMI levels in the HFD+AT and HFD+AT+Cu groups were significantly lower than the HFD (P≥0.05). Also, in the HFD+AT+Cu group, the weight and BMI levels were significantly lower and the adiponectin levels were significantly higher than the HFD+Cu group (P≥0.05).
Conclusion: It seems that exercise training and curcumin consumption both individually and synergistically can be effective in improving anthropometric characteristics by affecting adiponectin levels.he favorable effects of training and herbal supplements have been reported in this regard, the synergistic effects of the two are still a challenge for researchers.

Molecular docking reveals curcumin and catechin as potent inhibitors of histamine N-Methyltransferase (HNMT) and its T105I and L208P Variants
Mehrsa Amoozadeh , Mehdi Sadeghi ,
Volume 13, Issue 1 (9-2025)
Abstract
Background: Histamine plays a crucial role in regulating diverse physiological and pathophysiological functions, including gastric acid secretion, vasodilation, and bronchoconstriction. As a neurotransmitter, it is also implicated in allergic reactions, contributing to symptoms such as itching, sneezing, and inflammation. Given the potential adverse effects of histamine activity, antihistamines are frequently prescribed to mitigate its effects. However, the associated side effects of these drugs have prompted researchers to investigate natural alternatives, such as curcumin from turmeric and catechins from green tea. This study investigates the potential effect of curcumin and catechin on the histamine N-methyltransferase (HNMT) receptor and its T105I and L208P mutant variants.
Methods: Molecular docking was employed to analyze ligand-receptor interactions. The protein structure was obtained from the Protein Data Bank (PDB), and ligands were retrieved from PubChem. Ligand structures were optimized using Avogadro software, and docking studies were subsequently performed using AutoDock Tools and the Vina algorithm.
Results: Molecular docking studies have demonstrated strong binding affinities of catechin and curcumin to the target protein, with binding energies of -8.5 and -8.4 kcal/mol, respectively, which is more than twice the binding affinity of histamine (-4.0 kcal/mol). Analysis of docking results with variant proteins revealed a slight reduction in ligand binding energies compared to the normal protein. These findings suggest that both catechin and curcumin hold promise as potential therapeutic agents for patients with the studied variants of the target protein. Furthermore, docking analysis revealed key stabilizing interactions, including π–π stacking and hydrogen bonding.
Conclusion: Phe243 is a key binding site residue in HNMT, showing consistent strong interactions with all tested ligands. Its structural flexibility enables effective binding to compounds like catechin and curcumin, making it a prime target for designing new HNMT inhibitors.

Page 1 from 1     

© 2025 CC BY-NC 4.0 | Jorjani Biomedicine Journal

Designed & Developed by : Yektaweb