Faegheh Jafari Amoli, Seyed Ali Hosseini, Mohammad Ali Azarbayjani, Parvin Farzanegi Arkhazloo,
Volume 7, Issue 4 (12-2019)
Abstract
Background and objectives: It has been reported that deep-fried oils (DFOs) used in the preparation of fast foods can affect the immune system. On the other hand, regular physical activity and proper nutrition, in addition to affecting physical function, have a tremendous impact on the immune system. The aim of the present study was to investigate the anti-inflammatory effects of aerobic training (T) and octopamine (O) consumption in the heart tissue of rats fed DFO.
Methods: In this experimental study, 25 male Wistar rats with mean age of 20 weeks old and weighing 300- 350 were purchased and divided into 5 groups of 5 rats, including: 1) control, 2) DFO, 3) DFO+T, 4) DFO+O and 5) DFO+T+O. During four weeks, groups 2- 5 received DFO by gavage; groups 3- 5 ran on treadmill (with speed of 50% Vo2max in the first week which reached 65% Vo2max in the last week) five sessions per week and 20 minutes per session and groups 4-5 received 81 μmol/kg octopamine supplement peritoneally for 5 days per week. Nuclear factor kappa B (NF-κB) and tumor necrosis factor-alpha (TNF-α) gene expression were measured in heart tissue.
Results: DFO significantly increased NF-κB (P=0.005) and TNF-α (P=0.001) gene expression levels; T significantly on decreased NF-κB (P=0.01) and TNF-α (P=0.007) gene expression levels; O consumption significantly decreased NF-κB (P=0.001) and TNF-α (P=0.001) gene expression levels; however, the interactive effects of T and O consumption on NF-κB (P=0.57) and TNF-α (P=0.20) gene expression levels was not significant.
Conclusion: It seems that T and O consumption alone have anti-inflammatory effects on the heart tissue of rats fed DFO, however T and O do not have anti-inflammatory interactive effects.
Farah Nameni, Samira Falahi,
Volume 9, Issue 3 (10-2021)
Abstract
Background and Objective: Alzheimer's disease is a common cause of dementia and reduces progressive perception, memory, and tasks. This study aimed was to investigate the effects of interval training and octopamine extract on NLRP-1 and NLRP-3 in brain tissue of rats with Alzheimer's disease.
Material and Methods: The research method was experimental with a post-test design. A total of 42 male Wistar rats, all of which were eight weeks old, were obtained. Rats were randomly divided into 5 groups (healthy control, Alzheimer's sham, Alzheimer's+ interval training, Alzheimer's+ octopamine supplementation, Alzheimer's+ interval training+ octopamine supplementation). Alzheimer's induction was performed with beta-amyloid peptide 1-14. The training protocol was intense periodic. Octopamine was supplemented by intra-peritoneal injection. Morris's blue maze test was used for the spatial memory test. Seventy-two hours after the last training session, anesthetized rats and hippocampus were quickly extracted. A one-way ANOVA test was used to estimate intergroup differences after Alzheimer's induction.
Results: The results of one-way ANOVA showed a significant difference between the groups in NLRP-1 and NLRP-3 mRNA. Bonferroni test confirmed significant between the control group and Alzheimer's groups (P≤0.05).
Conclusion: The changes were considered to be synergistic of the beneficial effects of physical activity and octopamine in preventing or reducing the harmful effects of pathological conditions. Exercise and supplementation seem to be effective in the relationship between inflammatory and neurotrophic factors in neurological disorders.
