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Hamidreza Nikyar, Zohreh Reisi, Habibeh Farokhi,
Volume 1, Issue 2 (10-2013)
Abstract

Aims:

The purpose of this study was evaluating the efficacy of cognitive be Behavioral group therapy on

depression and hipness brain Tumor .

Method:

ineachgroup . the experimental group received 4weekly cognitive behavioral therapy session the question nears

depression beak and hope eshaneder were usadas the pre test ,post test and follow-up. The follow-up study was

conducted two months .

options were selected and assigned to two experimental and control group with brain tumor patients

Results:

after the last in tevrnationsessiony the result of covariance analysis showed that the mean scores

of depression in post test was significantly lower than control group (P<0.001) and follow-up (P<0.001) the

e result also showed that the scores of hope higher than con tral group in past test (P<0.001) and follow-up

(P<0.001) it is concluded that cognitive behavioral therapy, could happy life brain tumor.

Conclusion:

pharmacological interventions should be used in patients with brain tumors.

The results suggest that Cognitive Behavior Treatment boat as a valuable addition to surgical and
Dr Ahmad Jameii Khosroshahi, Mahmood Samadi, Dr Elnaz Skandartaj, Dr Agha Ali Yar-Makooyi, Farid Karkon Shayan,
Volume 5, Issue 1 (5-2017)
Abstract

Background & Objective: Pulmonary Arterial Hypertension (PAH) is one of the common complications of congenital heart diseases in children. The natriuretic peptides such as BNP, ANP and NT-Pro BNP are secreted in response to atrial and/or ventricular stretch. The aim of this study was to evaluate the correlation between pulmonary hypertension with BNP serum level and the quantity of left to right shunt based on echocardiography findings in children with congenital heart disease.
Method: In an analytical-descriptive study, 30 children with congenital heart disease after going through echocardiography and being confirmed to have one of VSD, ASD or PDA, were enrolled. The BNP serum level, quantity of the left to right shunt and systolic pulmonary pressure were measured.
Results: In the present study, 13 patients were male (43.3%) and 17 (56.7%) were female. The average BNP serum level of patients was 194.9 ± 21.2 (pg/ml). There was a significant relationship between systolic pulmonary pressure and BNP level among patients (P<0.001). There was also a positive correlation between average serum level of BNP and quantity of the left to right shunt (P=0.018).
Conclusion: On the basis of echocardiography findings, there was a positive correlation between systolic pulmonary pressure with BNP serum level and the quantity of left to right shunt. Therefore, it can be helpful among patients whom the pulmonary arterial pressure cannot be measured for any reason.

Samaneh Rafiei, Ali Asghar Ravasi, Abbas Ali Gaeini,
Volume 9, Issue 1 (3-2021)
Abstract

Background and Objective: Trimethyltin (TMT) is an organotin neurotoxin which causes cognitive disorders by the induction of selective damage in hippocampus. The present study evaluates the effect of 8-week swimming exercise (EX) and Gallic acid (GA) for working and avoidance memory, hippocampal oxidative stress indices and brain neurotrophic factor expression (BDNF) in rats after TMT intoxication.
Material and Methods: In this experimental study, 40 Wistar mature male rats were randomly put in 5 groups of control, TMT+NS, TMT+GA200, TMT+EX, TMT+GA200+EX. 24 hours after TMT intoxication (8mg/kg), 8 weeks of swimming exercise (3 sessions per week), and treatment with GA (200mg/kg) were done. Then, the evaluation of working and passive avoidance memory was performed respectively by the use of Y maze and shuttle box. Hippocampal level of catalase (CAT), total antioxidant capacity (TAC) and BDNF were done by ELISA method, and content of malondialdehyde (MDA) was performed by thiobarbituric acid (MDA). Statistical differences between groups were analyzed by two-way ANOVA and Bonferroni post hoc test.
Results: The significant decrease in the percentage of alteration behaviors, latency time to the dark room, along with BDNF, CAT, TAC and increase of MDA were seen in TMT+NS group compared to control group (p<0.01). Swimming exercise in the interaction with GA ameliorates working and avoidance memory by increasing BDNF, CAT, TAC, and decrease of MDA compared to TMT+NS group (p<0.05).
Conclusion: It seems that swimming exercise and GA administration improves cognitive symptoms following TMT intoxication simultaneously by decreasing oxidative stress and increasing BDNF expression.

Behrooz Yahyaei, Shirin Varmazyar,
Volume 9, Issue 2 (5-2021)
Abstract

Background and Objective: This study was conducted aimed to compare effects of Methylphenidate and endurance exercise on histopathological changes in brain tissue of male Wistar rats with attention deficit hyperactivity disorder (ADHD).
Material and Methods: In this study, 33 rats were divided into a control group (5 rats) and 4 experimental groups (28 rats) and 10 mg/kg of L-NAME (L-Arginine Methyl Ester) was injected peritoneally for 8 weeks for 6 days a week. Rats that tested positive for open test were used. Balance and motor coordination tests were taken after 8 weeks of training using Beam Walking or Balance Test. The drug group was given 1 mg per kg of Methylphenidate orally. The rats in the exercise group trained 30 minutes a day and 7 days a week for 4 weeks. Open Field Test was used to diagnose hyperactivity. 5-band treadmill was used for doing endurance exercise.
Results: The results of the present study show that the effect of exercise on reducing histopathological changes in brain tissue in neonatal rats with ADHD is present. Therefore, it can be stated that exercise can be an alternative to the drugs such as methylphenidate.
Conclusion: According to the studyresults, the effect of exercise alone to methylphenidate is greater on brain tissue changes. Although the drug has been more effective on improving some variables such as changes in gray matter, it has not reduced neuronal changes, congestion and inflammation not seen in the exercise group. Also, the study results of simultaneous drug use and exercise are satisfactory.


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