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Showing 5 results for Sharifi

Azita Fathnezhad Kazemi, Nasibe Sharifi, Dr Masoomeh Simbar,
Volume 5, Issue 1 (5-2017)
Abstract

Background & Objective: Nowadays, the participation of men in prenatal care is emphasized by international institutions to improve the health and reduce mortality of mothers and children. The purpose of this study was to review the various aspects of men participation in prenatal care.
Methods: All of the articles published since 2005 to 2016 containing full texts which were archived in SID, Medlib, Magiran, IranMedex, Google Scholar and Pubmed were searched with the keywords of “Men” and “the empowerment of women with prenatal care” in both Persian and English languages. After the initial investigation and search on the basis of sources, a total of 7 Persian and 28 English articles were included in this study.
Results: The results showed that the participation of men in prenatal care exerts positive effects on mother-infant outcomes. Increasing the expectations of women and core families are of the most important reasons showing the necessity of men participation in prenatal care. However, despite the positive attitude of couples towards men's participation, barriers such as lack of awareness among men and their undefined role in the field of prenatal care, economic and cultural issues and health system problems are the obstacles for men to cooperate in prenatal care.
Conclusion: Considering the important role of men in different areas of women's life and the positive effects of their participation in reproductive health of women, different strategies should be used to promote men's participation in order to introduce them to different aspects of fertility. Therefore, further research in this field seems necessary.

Seyed Farid Nourbakhsh, Reza Fadayevatan, Mahtab Alizadeh-Khoei, Farshad Sharifi,
Volume 5, Issue 2 (10-2017)
Abstract

Background & Objective: Dementia is associated with serious effects on memory, cognition and ability to carry out daily activities. There is evidence that impairment in activity of daily living (ADL) is even reported among elder patients who suffer from mild cognitive disorders. Therefore, we aimed to determine the status of ADL and instrumental activity of daily living (IADL) in healthy and cognitive impaired elderlies (MCI, Mild, and Moderate dementia).
Methods: In this cross-sectional study which was conducted in 2016, 300 elderlies (60 years and above) were selected using a classified cluster sampling in four groups (each group of 75 individuals). These groups comprised of healthy old people and elderlies with mild cognitive impairment (MCI) and mild to moderate dementia that were residing in rural areas of Isfahan and Tehran and were classified between stages of 1 to 5 according to the Global Deterioration Scale (GDS). All individuals in four groups were assessed by ADL and IADL evaluation tools. The geriatric depression scale (GDS-15) and DSM-IV scale were performed on healthy elderlies by a physician to confirm the lack of mild dementia or depression. Data were analyzed by SPSS 20 software and using descriptive statistics, analysis of variance and independent samples T-test.
Results: According to the cognitive impairment screening results by GDS, 76 elderlies were healthy, 75 were in MCI group, 72 individuals were diagnosed with mild dementia and 77 were suffering from moderate dementia. The mean scores of ADL tool on the basis of different cognitive stages of elderlies were statistically significant (p<0.001). The ADL scores among elderlies were lowered by increasing the severity of cognitive impairment. Moreover, the average scores of IADL among elderlies with different cognitive status were significantly different (p<0.001). The IADL scores in cases with moderate dementia were markedly declined in comparison to healthy subjects and elderlies with MCI and mild dementia.
Conclusion: Although applying the ADL and IADL tools are not considered as gold standards in rapid assessment of cognitive impairments among elderlies, they could be considered as useful and user friendly tools to detect performance alterations in elderlies with dementia to provide healthcare by geriatric teams.

Ali Mohammadnia, Khosro Jalali Dehkordi, Gholamreza Sharifi,
Volume 9, Issue 3 (10-2021)
Abstract

Background and Objective: The application of exercise training and herbal supplements is believed to be a typical approach in treating chronic diseases and metabolic disorders. Accordingly, given the healing effects of swimming training and cannabidiol (CBD) oil consumption, the aim of the current study was to reveal if eight weeks of swimming training and CBD oil consumption downregulates the expression of MAPK, PPARα genes in the heart tissue of myocardial infarction rats.
Material and Methods: In the present experimental study, 20 myocardial infarction rats were divided into four groups of five animals, including: 1) control, 2 swimming training, 3) CBD, 4) CBD + swimming training, and 5) healthy control. For eight weeks, groups 3 and 4 consumed 50 mg/kg of CBD daily by gavage, and groups 2 and 4 performed swimming training five days a week. Induction of myocardial ischemia was performed by subcutaneous injection of isoproterenol (50 mg/kg i.p.), in myocardial infarction rats. Bax and Bcl2 cardiomyocytes were measured by PCR-RT. For data analysis, one-way analysis variance test was used to compare inter-group differences at P<0.05.
Results: Swimming training, CBD consumption and swimming training with CBD consumption had a significant effect on reducing MAPK gene expression in cardiac tissue (P≤0.05). Also, swimming training with CBD consumption had a greater effect than swimming training and CBD consumption alone on reducing PPARα gene expression in cardiac tissue (P≤0.05).
Conclusion: It appears that application of swimming training with CBD oil consumption has more positive impacts on improving MAPK and PPARα gene expression levels in the heart tissue of rats with myocardial infarction than using each one alone. Besides, swimming training with CBD oil consumption plays a role in the rehabilitation process and improves key factors involved in cardiovascular health.

Monireh Omomi, Farzaneh Taghian, Gholamreza Sharifi,
Volume 10, Issue 2 (5-2022)
Abstract

Background and objectives: Zingiber officinale extract can control cardiovascular risk factors. Moreover, endurance training may effectively rehabilitate myocardial infarction by strengthening the myocardial muscle tissue. In-silico analysis identified essential genes involved in the heart damage process based on data from the DisGeNET database. Hence, we estimated the affinity of chemical and bioactive molecules for PPARγ. Therefore, this study aimed to investigate the effect of endurance exercise alone or combined with Zingiber officinale extract on Myocardial infarction rats.
Material and Methods: Twenty-five male rats were randomly divided into five groups, including (1) group of myocardial infarctions (MI) induced by subcutaneous injection of isoproterenol, (2) myocardial infarction+exercise (MI+EX), (3) myocardial infarction+Zingiber Officinale extraction administered orally (MI+GE), (4) myocardial infarction+exercise+Zingiber Officinale extract (MI+EX+GE), and (5) Control group. The qPCR-Real Time technique was used to measure the expression of PGC1-ɑ, PPARγ, and TNF-ɑ genes. We evaluated the concentration of Troponin-1 as a vital myocardial ischemia marker.
Results: In bioinformatics analysis, we found that the PPARγ, PGC1-ɑ, and TNF-ɑ pathways were critical in heart injury. Also, the effects of Zingiber officinale on heart tissue were detected through PPARγ by drug design. Endurance training combined with Zingiber officinale consumption reduced the expression of TNF-ɑ, Troponin-1 and increased the PGC1-ɑ, PPARγ genes. Furthermore, consumption of Zingiber officinale extraction improved the levels of PGC1-ɑ, PPARγ, TNF-ɑ, and Troponin-1.
Conclusion: Our data indicated that six weeks of endurance training and consumption of Zingiber officinale extract could reduce the relative expression of the TNF-ɑ and significantly increase the level of PGC1-ɑ, PPARγ.


Kobra Sharifiyan, Mohammad Jafar Tarokh, Seyed Alireza Hashemi Golpayegani,
Volume 10, Issue 4 (12-2022)
Abstract

Background and Objectives: One of the complicated processes in the Ministry of Health is the process of registering pharmaceuticals .Since there are different soft wares for registration of products, and since parallel services concuss waste of time and money, it is necessary to provide integrated software in the form of services. This goal can be achieved when services are identified and combined in integrated soft wares.
Material and Methods: present study is an applied research, In order to identify the services of an integrated system for recording pharmaceutical supplies, first the Gray-Wolf multi-objective optimization (GWO) algorithm was proposed. Then the values of the algorithm parameters were extracted by the goal-based requirements analysis method and the algorithm was implemented. Finally the best services were extracted by the hierarchical analysis process.
Results: Considering that the results of present study are an operational project in the Ministry of Health, by implementing the algorithm proposed by Gray Wolf, services were identified, which can be used to create integrated software for registering pharmaceutical supplies.
Conclusion: Creating an integrated system for registering pharmaceutical supplies is one of the important challenges of the Ministry of Health. This can be achieved by identifying services and combining these services to create an integrated system.


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