Jorjani Biomedicine Journal

Background and objective: Some common problems in the health care system are Microbial resistance to antibiotics, the side effects of food additives, and preservatives. Considering the antibiotic resistance of microorganisms and the need to identify new compounds, the present study was conducted to determine the antimicrobial effects of Artemisia extracts.
Material And Method The study was performed in two stages including extraction and determination of antibacterial properties of aqueous, ethanolic, methanolic, acetone/ethanolic, and hydroethanolic extracts of Artemisia on standard Pseudomonas aeruginosa, Streptococcus pyogenes, and oral bacteria sample. The well diffusion method was performed to evaluate the concentration that had an inhibitory and bactericidal effect.
Result: Aqueous extract had an effect on the oral bacteria sample (8 mm), the methanolic extract had an effect on S. pyogenes and oral bacteria sample (15 mm) and finally acetone/ethanolic extracts had antimicrobial properties against S. pyogenes (16 mm). The concentration used for all five extracts was 50 mg/ml and showed an inhibition effect on the growth of S. pyogenes standard strain and oral bacteria sample. The less serial dilutions of extracts were tested but no antibacterial effects were seen. So, 50 mg/ml was the minimum concentration that had an inhibitory and bactericidal effect.
Conclusion: It can be inferred that aqueous, methanolic, and acetone/ethanolic extracts of Artemisia had the highest inhibitory effect on S. pyogenes and the oral bacteria sample. Consequently, by applying different extraction methods and by utilizing different solvents, it may be possible to more efficiently obtain biomaterials with antimicrobial properties from this plant.
 

Background and Objective: Reports indicate that over 60% of people with diabetes die from cardiovascular diseases. The present study was conducted to investigate the interactive effects of resistance training and genistein consumption on the serum levels of vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1) and C-Reactive Protein (CRP) in diabetic rats with streptozotocin.
Material And Methods: In this experimental study, 40 diabetic rats were selected and divided into 5 groups of 8 subjects, including: (1) control, (2) sham (dimethyl sulfoxide), (3) resistance training (4), genistein consumption, and (5) resistance training and genistein consumption. Rats in groups 3 and 5 received 8 weeks of resistance training, 3 sessions per week, with 30 to 100% body weight, and rats in groups 4 and 5 received 30 mg/kg of peritoneal genistein per day. Data were analyzed using independent sample t-test and two-way ANOVA in SPSS software (p≤0.05).
Results: Genistein consumption has a significant effect on reduced serum levels of VCAM and ICAM in diabetic rats (p≤0.05). Eight weeks of resistance training has a significant effect on reduced serum levels of ICAM and CRP in diabetic rats (p≤0.05). Resistance training and genistein consumption have interactive effects on reduced serum levels of VCAM and CRP in diabetic rats (p≤0.05).
Conclusion: Resistance training and genistein consumption simultaneously appear to reduce the risk of atherosclerosis in diabetic rats.

Background and Objective: As a high-energy demanding tissue, the heart is exposed to a high level of ROS molecules such as H2O2, leading to cardiovascular disorders through damaging macromolecules such as DNA and disrupting ATP production. Hence, this study aimed to investigate the simultaneous effect of aerobic exercise (Ae) and Linum Usitatissimum (Lu) supplementation on DNA damage and ATP synthesis in heart and aorta endothelial tissues in rats poisoned with hydrogen peroxide (H2O2).
Material and Methods: 56 male Wistar Albino rats were randomly divided into 7 groups, including HC (Healthy Control), TC (Toxicated Control), Lu1 (Received 5 mg/kg of Lu), Lu2 (Received 10 mg/kg of Lu), Ae (Received only Aerobic Exercise), Ae Lu1, and Ae Lu2. Then, all groups got poisoned by H2O2 except HC. Next, they received Linum Usitatissimum (Lu) supplementation and Low-Intensity Interval Training (LIIT). Finally, 24h after the last treatment session, the level of 6-methylguanine (6MG) and ATP were measured via the ELISA technique in cardiovascular tissue.
Results: The findings determined that Lu supplementation and Ae significantly diminish the 6-methyl guanine level in endothelial (F=111.3, p=0.0008, ƞ=0.9823) and heart cells (F=147.9, p=0.0005, ƞ=0.9867). Also, the ATP level was increased significantly in endothelial (F=342.6, p=0.0003, ƞ=0.9942) and heart cells (F=135.1, p=0.0013, ƞ=0.9854). However, no considerable changes were found for both factors in groups who received Ae or Lu singularly.
Conclusion: The study showed that concurrent administration of Lu and Ae could exert dynamic cardioprotective properties through their antioxidant effects.

Background: Marital satisfaction (MS) is a multidimensional concept related to the individual characteristics of couples, the dynamics of inter-spousal relationships, and intergenerational attachments. We aimed to determine the predictive model of marital satisfaction in breastfeeding primiparous women based on demographic information.
Method: This descriptive-analytical cross-sectional study was conducted between August and November 2015 on 160 primiparous breastfeeding women with full-term, healthy, singleton infant who had been referred to the health centers of Babol, north of Iran, for the two-month vaccination. The research samples were selected using the convenience sampling method among ten centers in Babol, selected randomly through a lottery. They completed the demographic information form and the Persian version of the 47-items Enrich's marital satisfaction scale (EMS) in a self-report manner. The obtained scores were converted into scale scores (0-100). Data were analyzed using SPSS (version 16) with descriptive statistics (mean, standard deviation, frequency) and inferential statistics (Student's t-test, ANOVA and Stepwise Multiple regression tests) at a confidence level of 0.05. The Kolmogorov-Smirnov and Shapirovilk tests were used as appropriate.
Results: The means± SD marital satisfaction score of breastfeeding primiparous women was 86.05±12.91 (High Level). The three variables of spouse's education (X1), Spouse participation in housework (X2), and age of marriage (X3) were able to predict the level of marital satisfaction (using the formula Y = 33.89 + 2.02 X1 + 4.17 X2 + 0.40 X3). There was no relationship between marital satisfaction with age, spouse's age, employment status, spouse's employment status, education, type of delivery, type of marriage, income, and housing status.
Conclusion: The increase in spouse's education, spouse's participation in the home, and marriage age were associated with higher marital satisfaction. Based on the three mentioned variables, the prediction model obtained can be used to estimate the marital satisfaction of breastfeeding primiparous women.